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Bioinspired Universal Monolayer Coatings by Combining Concepts from Blood Protein Adsorption and Mussel Adhesion

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Institute of Chemistry and Biochemistry, Freie Universität Berlin, Takustrasse 3, 14195 Berlin, Germany
Multifunctional Biomaterials for Medicine, Helmholtz Virtual Institute, Kantstrasse 55, 14513 Teltow-Seehof, Germany
Department of Biointerface Science & Technology, Max-Planck Institute for Medical Research, Heisenbergstrasse 3, 70569 Stuttgart, Germany
Fraunhofer Institute for Manufacturing Technology and Advanced Materials, Wiener Strasse 12, 28359 Bremen, Germany
§ Soft Matter and Functional Materials, Helmholtz-Zentrum Berlin für Materialien und Energie GmbH, Hahn-Meitner-Platz 1, 14109 Berlin, Germany
Cite this: ACS Appl. Mater. Interfaces 2017, 9, 7, 6624–6633
Publication Date (Web):January 24, 2017
Copyright © 2017 American Chemical Society

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    Despite the increasing need for universal polymer coating strategies, only a few approaches have been successfully developed, and most of them are suffering from color, high thickness, or high roughness. In this paper, we present for the first time a universal monolayer coating that is only a few nanometers thick and independent of the composition, size, shape, and structure of the substrate. The coating is based on a bioinspired synthetic amphiphilic block copolymer that combines two concepts from blood protein adsorption and mussel adhesion. This polymer can be rapidly tethered on various substrates including both planar surfaces and nanosystems with high grafting density. The resulting monolayer coatings are, on the one hand, inert to the adsorption of multiple polymer layers and prevent biofouling. On the other hand, they are chemically active for secondary functionalization and provide a new platform for selective material surface modification.

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