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Versatile Fabrication Approach of Conductive Hydrogels via Copolymerization with Vinyl Monomers

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† § ∥ †School of Materials Science and Engineering, ‡School of Chemistry, §Australian Centre for NanoMedicine and ARC Centre of Excellence in Convergent BioNano Science and Technology, and ∥Centre for Advanced Macromolecular Design, UNSW Australia, Sydney, New South Wales 2052, Australia
⊥ Cardiothoracic and Vascular Health, Kolling Institute, Sydney Medical School (Northern), University of Sydney, Sydney, New South Wales 2000, Australia
# Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, United States
∇ Biomedical Engineering and Neuroscience (BENS) Research Group, University of Western Sydney, Penrith, New South Wales 2751, Australia
○ Electron Microscopy Centre, Innovation Campus, University of Wollongong, Squires Way, Fairy Meadow, Wollongong, New South Wales 2519, Australia
*E-mail: [email protected]
Cite this: ACS Appl. Mater. Interfaces 2017, 9, 50, 44124–44133
Publication Date (Web):November 27, 2017
https://doi.org/10.1021/acsami.7b15019
Copyright © 2017 American Chemical Society
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    Abstract

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    Functionalized poly(ethylene dioxythiophene) (f-PEDOT) was copolymerized with two vinyl monomers of different hydrophilicity, acrylic acid and hydroxyethyl methacrylate, to produce electroconductive hydrogels with a range of physical and electronic properties. These hydrogels not only possessed tailored physical properties, such as swelling ratios and mechanical properties, but also displayed electroactivity dependent on the chemical composition of the network. Raman spectroscopy indicated that the functional PEDOT in the hydrogels is in an oxidized form, most likely accounting for the good electrochemical response of the hydrogels observed in physiological buffer. In vitro cell studies showed that cardiac cells respond differently when seeded on hydrogel substrates with different compositions. This study presents a facile approach for the fabrication of electroconductive hydrogels with a range of properties, paving the way for scaffolds that can meet the requirements of different electroresponsive tissues.

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    The Supporting Information is available free of charge on the ACS Publications website at DOI: 10.1021/acsami.7b15019.

    • Cyclic voltammetry of PEDOT_3AA_HEMA and PEDOT_AA_3HEMA; Raman spectra of the hydrogel networks and films of PEDOT_COOH and the commercial PEDOT_PSS; SEM micrographs at a larger scale of the hydrogel networks; live/dead images of cardiac cells cultured on the hydrogels; relative expression of the G0S2 gene (PDF)

    • Movie showing beating cardiomyocytes on the PEDOT_AA_HEMA hydrogel (AVI)

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