ACS Publications. Most Trusted. Most Cited. Most Read
My Activity

Figure 1Loading Img

Versatile Fabrication Approach of Conductive Hydrogels via Copolymerization with Vinyl Monomers

View Author Information
† § ∥ School of Materials Science and Engineering, School of Chemistry, §Australian Centre for NanoMedicine and ARC Centre of Excellence in Convergent BioNano Science and Technology, and Centre for Advanced Macromolecular Design, UNSW Australia, Sydney, New South Wales 2052, Australia
Cardiothoracic and Vascular Health, Kolling Institute, Sydney Medical School (Northern), University of Sydney, Sydney, New South Wales 2000, Australia
# Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, United States
Biomedical Engineering and Neuroscience (BENS) Research Group, University of Western Sydney, Penrith, New South Wales 2751, Australia
Electron Microscopy Centre, Innovation Campus, University of Wollongong, Squires Way, Fairy Meadow, Wollongong, New South Wales 2519, Australia
Cite this: ACS Appl. Mater. Interfaces 2017, 9, 50, 44124–44133
Publication Date (Web):November 27, 2017
Copyright © 2017 American Chemical Society

    Article Views





    Read OnlinePDF (6 MB)
    Supporting Info (2)»


    Abstract Image

    Functionalized poly(ethylene dioxythiophene) (f-PEDOT) was copolymerized with two vinyl monomers of different hydrophilicity, acrylic acid and hydroxyethyl methacrylate, to produce electroconductive hydrogels with a range of physical and electronic properties. These hydrogels not only possessed tailored physical properties, such as swelling ratios and mechanical properties, but also displayed electroactivity dependent on the chemical composition of the network. Raman spectroscopy indicated that the functional PEDOT in the hydrogels is in an oxidized form, most likely accounting for the good electrochemical response of the hydrogels observed in physiological buffer. In vitro cell studies showed that cardiac cells respond differently when seeded on hydrogel substrates with different compositions. This study presents a facile approach for the fabrication of electroconductive hydrogels with a range of properties, paving the way for scaffolds that can meet the requirements of different electroresponsive tissues.

    Supporting Information

    Jump To

    The Supporting Information is available free of charge on the ACS Publications website at DOI: 10.1021/acsami.7b15019.

    • Cyclic voltammetry of PEDOT_3AA_HEMA and PEDOT_AA_3HEMA; Raman spectra of the hydrogel networks and films of PEDOT_COOH and the commercial PEDOT_PSS; SEM micrographs at a larger scale of the hydrogel networks; live/dead images of cardiac cells cultured on the hydrogels; relative expression of the G0S2 gene (PDF)

    • Movie showing beating cardiomyocytes on the PEDOT_AA_HEMA hydrogel (AVI)

    Terms & Conditions

    Most electronic Supporting Information files are available without a subscription to ACS Web Editions. Such files may be downloaded by article for research use (if there is a public use license linked to the relevant article, that license may permit other uses). Permission may be obtained from ACS for other uses through requests via the RightsLink permission system:

    Cited By

    This article is cited by 25 publications.

    1. Anna Mariano, Claudia Lubrano, Ugo Bruno, Chiara Ausilio, Nikita Bhupesh Dinger, Francesca Santoro. Advances in Cell-Conductive Polymer Biointerfaces and Role of the Plasma Membrane. Chemical Reviews 2022, 122 (4) , 4552-4580.
    2. Ali Mousavi, Sadaf Vahdat, Nafiseh Baheiraei, Mehdi Razavi, Mohammad Hadi Norahan, Hossein Baharvand. Multifunctional Conductive Biomaterials as Promising Platforms for Cardiac Tissue Engineering. ACS Biomaterials Science & Engineering 2021, 7 (1) , 55-82.
    3. Nuria Alegret, Antonio Dominguez-Alfaro, David Mecerreyes. 3D Scaffolds Based on Conductive Polymers for Biomedical Applications. Biomacromolecules 2019, 20 (1) , 73-89.
    4. Parvin Shokrollahi, Yadollah Omidi, Luigi X. Cubeddu, Hossein Omidian. Conductive polymers for cardiac tissue engineering and regeneration. Journal of Biomedical Materials Research Part B: Applied Biomaterials 2023, 111 (11) , 1979-1995.
    5. Vinh Van Tran, Kyungjun Lee, Thanh Ngoc Nguyen, Daeho Lee. Recent Advances and Progress of Conducting Polymer-Based Hydrogels in Strain Sensor Applications. Gels 2023, 9 (1) , 12.
    6. Anna Mariano, Claudia Latte Bovio, Valeria Criscuolo, Francesca Santoro. Bioinspired micro- and nano-structured neural interfaces. Nanotechnology 2022, 33 (49) , 492501.
    7. Shahryar Moradi Falah Langeroodi, Maryam Kazemipour, Touba Eslaminejad, Amirhossein Naghipour, Mehdi Ansari. Molecular imprinted polymer with dorzolamide for contact lens applications assisted by computational and experimental design. Reactive and Functional Polymers 2022, 178 , 105355.
    8. Rebecca L. Keate, Joshua Tropp, Caralyn P. Collins, Henry Oliver T. Ware, Anthony J. Petty, Guillermo A. Ameer, Cheng Sun, Jonathan Rivnay. 3D‐Printed Electroactive Hydrogel Architectures with Sub‐100 µm Resolution Promote Myoblast Viability. Macromolecular Bioscience 2022, 22 (8)
    9. Modi Gu, Lorenzo Travaglini, Jonathan Hopkins, Daniel Ta, Antonio Lauto, Pawel Wagner, Klaudia Wagner, Erica Zeglio, Lilli Jephcott, David L. Officer, Damia Mawad. Molecular design of an electropolymerized copolymer with carboxylic and sulfonic acid functionalities. Synthetic Metals 2022, 285 , 117029.
    10. Clara Liu Chung Ming, Eitan Ben-Sefer, Carmine Gentile. Stem Cell-Based 3D Bioprinting for Cardiovascular Tissue Regeneration. 2022, 281-312.
    11. Chujia Li. Towards conductive hydrogels in e-skins: a review on rational design and recent developments. RSC Advances 2021, 11 (54) , 33835-33848.
    12. Liudmila Polonchuk, Lydia Surija, Min Ho Lee, Poonam Sharma, Clara Liu Chung Ming, Florian Richter, Eitan Ben-Sefer, Maryam Alsadat Rad, Hadi Mahmodi Sheikh Sarmast, Wafa Al Shamery, Hien A Tran, Laura Vettori, Fabian Haeusermann, Elysse C Filipe, Jelena Rnjak-Kovacina, Thomas Cox, Joanne Tipper, Irina Kabakova, Carmine Gentile. Towards engineering heart tissues from bioprinted cardiac spheroids. Biofabrication 2021, 13 (4) , 045009.
    13. , Parvin Alizadeh, Mohammad Soltani, Rumeysa Tutar, Ehsanul Hoque Apu, Chima V. Maduka, Bige Deniz Unluturk, Christopher H. Contag, Nureddin Ashammakhi. Use of electroconductive biomaterials for engineering tissues by 3D printing and 3D bioprinting. Essays in Biochemistry 2021, 65 (3) , 441-466.
    14. Poonam Sharma, Xiaowei Wang, Clara Liu Chung Ming, Laura Vettori, Gemma Figtree, Andrew Boyle, Carmine Gentile. Considerations for the Bioengineering of Advanced Cardiac In Vitro Models of Myocardial Infarction. Small 2021, 17 (15)
    15. Mushtaq A. Bhat, Reyaz A. Rather, Aabid H. Shalla. PEDOT and PEDOT:PSS conducting polymeric hydrogels: A report on their emerging applications. Synthetic Metals 2021, 273 , 116709.
    16. Hongwei Zhou, Zhiwen Wang, Weifeng Zhao, Ximan Tong, Xilang Jin, Xingcai Zhang, You Yu, Hanbin Liu, Yichao Ma, Shushu Li, Weixing Chen. Robust and sensitive pressure/strain sensors from solution processable composite hydrogels enhanced by hollow-structured conducting polymers. Chemical Engineering Journal 2021, 403 , 126307.
    17. Carly Baker, Klaudia Wagner, Pawel Wagner, David L. Officer, Damia Mawad. Biofunctional conducting polymers: synthetic advances, challenges, and perspectives towards their use in implantable bioelectronic devices. Advances in Physics: X 2021, 6 (1)
    18. Nuria Alegret, Antonio Dominguez-Alfaro, David Mecerreyes. Conductive Polymers Building 3D Scaffolds for Tissue Engineering. 2020, 383-414.
    19. Christopher D Roche, Russell J L Brereton, Anthony W Ashton, Christopher Jackson, Carmine Gentile. Current challenges in three-dimensional bioprinting heart tissues for cardiac surgery. European Journal of Cardio-Thoracic Surgery 2020, 58 (3) , 500-510.
    20. Marta Mazzola, Elisa Di Pasquale. Toward Cardiac Regeneration: Combination of Pluripotent Stem Cell-Based Therapies and Bioengineering Strategies. Frontiers in Bioengineering and Biotechnology 2020, 8
    21. Bikendra Maharjan, Dinesh Kumar, Ganesh Prasad Awasthi, Deval Prasad Bhattarai, Ju Yeon Kim, Chan Hee Park, Cheol Sang Kim. Synthesis and characterization of gold/silica hybrid nanoparticles incorporated gelatin methacrylate conductive hydrogels for H9C2 cardiac cell compatibility study. Composites Part B: Engineering 2019, 177 , 107415.
    22. Xiaoping Song, Jie Mei, Genlan Ye, Leyu Wang, Annada Ananth, Lei Yu, Xiaozhong Qiu. In situ pPy-modification of chitosan porous membrane from mussel shell as a cardiac patch to repair myocardial infarction. Applied Materials Today 2019, 15 , 87-99.
    23. Kristina Fidanovski, Damia Mawad. Conjugated Polymers in Bioelectronics: Addressing the Interface Challenge. Advanced Healthcare Materials 2019, 8 (10)
    24. Laure V. Kayser, Darren J. Lipomi. Stretchable Conductive Polymers and Composites Based on PEDOT and PEDOT:PSS. Advanced Materials 2019, 31 (10)
    25. Kaveh Roshanbinfar, Lena Vogt, Boris Greber, Sebastian Diecke, Aldo R. Boccaccini, Thomas Scheibel, Felix B. Engel. Electroconductive Biohybrid Hydrogel for Enhanced Maturation and Beating Properties of Engineered Cardiac Tissues. Advanced Functional Materials 2018, 28 (42)

    Pair your accounts.

    Export articles to Mendeley

    Get article recommendations from ACS based on references in your Mendeley library.

    Pair your accounts.

    Export articles to Mendeley

    Get article recommendations from ACS based on references in your Mendeley library.

    You’ve supercharged your research process with ACS and Mendeley!

    STEP 1:
    Click to create an ACS ID

    Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

    Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

    Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

    Your Mendeley pairing has expired. Please reconnect