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Colonization of Electrospun Polycaprolactone Fibers by Relevant Pathogenic Bacterial Strains

  • Carlos Rumbo*
    Carlos Rumbo
    International Research Center in Critical Raw Materials-ICCRAM, Universidad de Burgos, Plaza Misael Bañuelos s/n, 09001 Burgos, Spain
    Departamento de Química, Facultad de Ciencias, Universidad de Burgos, 09001, Burgos, Spain
    *E-mail: [email protected]
    More by Carlos Rumbo
  • Juan Antonio Tamayo-Ramos*
    Juan Antonio Tamayo-Ramos
    International Research Center in Critical Raw Materials-ICCRAM, Universidad de Burgos, Plaza Misael Bañuelos s/n, 09001 Burgos, Spain
    *E-mail: [email protected]
  • M. Federica Caso
    M. Federica Caso
    Nanofaber srl., Via Anguillarese 301, 00123 Rome, Italy
  • Antonio Rinaldi
    Antonio Rinaldi
    Italian National Agency for New Technologies, Energy and Sustainable Economic Development (ENEA), Casaccia Research Centre, Via Anguillarese 301, 00123 Rome, Italy
  • Lorena Romero-Santacreu
    Lorena Romero-Santacreu
    International Research Center in Critical Raw Materials-ICCRAM, Universidad de Burgos, Plaza Misael Bañuelos s/n, 09001 Burgos, Spain
  • Roberto Quesada
    Roberto Quesada
    Departamento de Química, Facultad de Ciencias, Universidad de Burgos, 09001, Burgos, Spain
  • , and 
  • Santiago Cuesta-López*
    Santiago Cuesta-López
    International Research Center in Critical Raw Materials-ICCRAM, Universidad de Burgos, Plaza Misael Bañuelos s/n, 09001 Burgos, Spain
    *E-mail: [email protected]
Cite this: ACS Appl. Mater. Interfaces 2018, 10, 14, 11467–11473
Publication Date (Web):March 20, 2018
https://doi.org/10.1021/acsami.7b19440
Copyright © 2018 American Chemical Society
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Abstract

Abstract Image

Electrospun biodegradable polymers have emerged as promising materials for their applications in several fields, including biomedicine and food industry. For this reason, the susceptibility of these materials to be colonized by different pathogens is a critical issue for public health, and their study can provide future knowledge to develop new strategies against bacterial infections. In this work, the ability of three pathogenic bacterial species (Pseudomonas aeruginosa, Acinetobacter baumannii, and Listeria monocytogenes) to adhere and form biofilm in electrospun polycaprolactone (PCL) microfibrous meshes was investigated. Bacterial attachment was analyzed in meshes with different microstructure, and comparisons with other materials (borosilicate glass and electrospun polylactic acid (PLA)) fibers were assessed. Analysis included colony forming unit (CFU) counts, scanning electron microscopy (SEM), and crystal violet (CV) staining. All the obtained data suggest that PCL meshes, regardless of their microstructure, are highly susceptible to be colonized by the pathogenic relevant bacteria used in this study, so a pretreatment or a functionalization with compounds that present some antimicrobial activity or antibiofilm properties is highly recommended before their application. Moreover, an experiment designed to simulate a chronic wound environment was used to demonstrate the ability of these meshes to detach biofilms from the substratum where they have developed, thus making them promising candidates to be used in wound cleaning and disinfection.

Cited By

This article is cited by 13 publications.

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  2. Kim W. J. Verhorstert, Zeliha Guler, Leonie de Boer, Martijn Riool, Jan-Paul W. R. Roovers, Sebastian A. J. Zaat. In Vitro Bacterial Adhesion and Biofilm Formation on Fully Absorbable Poly-4-hydroxybutyrate and Nonabsorbable Polypropylene Pelvic Floor Implants. ACS Applied Materials & Interfaces 2020, 12 (48) , 53646-53653. https://doi.org/10.1021/acsami.0c14668
  3. Laura Tamayo, Francisco Melo, Leonardo Caballero, Eugenio Hamm, M. Díaz, M. S. Leal, N. Guiliani, M. D. Urzúa. Does Bacterial Elasticity Affect Adhesion to Polymer Fibers?. ACS Applied Materials & Interfaces 2020, 12 (12) , 14507-14517. https://doi.org/10.1021/acsami.9b21060
  4. Lee J. Simcox, Rui P. A. Pereira, Elizabeth M. H. Wellington, Julie V. Macpherson. Boron Doped Diamond as a Low Biofouling Material in Aquatic Environments: Assessment of Pseudomonas aeruginosa Biofilm Formation. ACS Applied Materials & Interfaces 2019, 11 (28) , 25024-25033. https://doi.org/10.1021/acsami.9b07245
  5. Yue Ma, Jiaying Li, Yang Si, Kang Huang, Nitin Nitin, Gang Sun. Rechargeable Antibacterial N-Halamine Films with Antifouling Function for Food Packaging Applications. ACS Applied Materials & Interfaces 2019, 11 (19) , 17814-17822. https://doi.org/10.1021/acsami.9b03464
  6. Juan Antonio Tamayo-Ramos, Carlos Rumbo, Federica Caso, Antonio Rinaldi, Sebastiano Garroni, Andrea Notargiacomo, Lorena Romero-Santacreu, Santiago Cuesta-López. Analysis of Polycaprolactone Microfibers as Biofilm Carriers for Biotechnologically Relevant Bacteria. ACS Applied Materials & Interfaces 2018, 10 (38) , 32773-32781. https://doi.org/10.1021/acsami.8b07245
  7. Anzhela Galstyan, Hussaini Majiya, Urlich Dobrindt. Regulation of photo triggered cytotoxicity in electrospun nanomaterials: role of photosensitizer binding mode and polymer identity. Nanoscale Advances 2021, 4 (1) , 200-210. https://doi.org/10.1039/D1NA00717C
  8. Daniele Valerini, Loredana Tammaro, Roberta Vitali, Gloria Guillot, Antonio Rinaldi. Sputter-Deposited Ag Nanoparticles on Electrospun PCL Scaffolds: Morphology, Wettability and Antibacterial Activity. Coatings 2021, 11 (3) , 345. https://doi.org/10.3390/coatings11030345
  9. J Jusic, S Tamantini, M Romagnoli, V Vinciguerra, E Di Mattia, F Zikeli, M Cavalera, G Scarascia Mugnozza. Improving sustainability in wood coating: testing lignin and cellulose nanocrystals as additives to commercial acrylic wood coatings for bio-building. iForest - Biogeosciences and Forestry 2021, 14 (6) , 499-507. https://doi.org/10.3832/ifor3782-014
  10. Alexander G. Morozov, Danila A. Razborov, Tatevik A. Egiazaryan, Maxim A. Baten’kin, Diana Ya. Aleynik, Marfa N. Egorikhina, Yulia P. Rubtsova, Irina N. Charikova, Sergei A. Chesnokov, Igor L. Fedushkin. In Vitro Study of Degradation Behavior, Cytotoxicity, and Cell Adhesion of the Atactic Polylactic Acid for Biomedical Purposes. Journal of Polymers and the Environment 2020, 28 (10) , 2652-2660. https://doi.org/10.1007/s10924-020-01803-x
  11. Fabrizio De Cesare, Elena Di Mattia, Eyal Zussman, Antonella Macagnano. A 3D soil-like nanostructured fabric for the development of bacterial biofilms for agricultural and environmental uses. Environmental Science: Nano 2020, 7 (9) , 2546-2572. https://doi.org/10.1039/D0EN00268B
  12. Fabrizio De Cesare, Elena Di Mattia, Eyal Zussman, Antonella Macagnano. A study on the dependence of bacteria adhesion on the polymer nanofibre diameter. Environmental Science: Nano 2019, 6 (3) , 778-797. https://doi.org/10.1039/C8EN01237G
  13. Raghavendra Ramalingam, Chetna Dhand, Chak Leung, Hariharan Ezhilarasu, Praseetha Prasannan, Seow Ong, Sundarapandian Subramanian, Mohammed Kamruddin, Rajamani Lakshminarayanan, Seeram Ramakrishna, Navin Verma, Kantha Arunachalam. Poly-ε-Caprolactone/Gelatin Hybrid Electrospun Composite Nanofibrous Mats Containing Ultrasound Assisted Herbal Extract: Antimicrobial and Cell Proliferation Study. Nanomaterials 2019, 9 (3) , 462. https://doi.org/10.3390/nano9030462

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