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    Research Article

    Engineering the Bioactivity of Flame-Made Ceria and Ceria/Bioglass Hybrid Nanoparticles
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    • Martin T. Matter
      Martin T. Matter
      Laboratory for Particles-Biology Interactions, Department of Materials Meet Life, Swiss Federal Laboratories for Materials Science and Technology (Empa), Lerchenfeldstrasse 5, CH-9014 St. Gallen, Switzerland
      Particle Technology Laboratory, Institute of Process Engineering, Department of Mechanical and Process Engineering, ETH Zurich, Sonneggstrasse 3, CH-8092 Zurich, Switzerland
      More by Martin T. Matter
      Orcidhttp://orcid.org/0000-0003-0748-1508
    • Lea A. Furer
      Lea A. Furer
      Laboratory for Particles-Biology Interactions, Department of Materials Meet Life, Swiss Federal Laboratories for Materials Science and Technology (Empa), Lerchenfeldstrasse 5, CH-9014 St. Gallen, Switzerland
      More by Lea A. Furer
    • Fabian H. L. Starsich
      Fabian H. L. Starsich
      Particle Technology Laboratory, Institute of Process Engineering, Department of Mechanical and Process Engineering, ETH Zurich, Sonneggstrasse 3, CH-8092 Zurich, Switzerland
      More by Fabian H. L. Starsich
      Orcidhttp://orcid.org/0000-0003-0724-764X
    • Giuseppino Fortunato
      Giuseppino Fortunato
      Laboratory for Biomimetic Membranes and Textiles, Department of Materials Meet Life, Swiss Federal Laboratories for Materials Science and Technology (Empa), Lerchenfeldstrasse 5, CH-9014 St. Gallen, Switzerland
      More by Giuseppino Fortunato
    • Sotiris E. Pratsinis
      Sotiris E. Pratsinis
      Particle Technology Laboratory, Institute of Process Engineering, Department of Mechanical and Process Engineering, ETH Zurich, Sonneggstrasse 3, CH-8092 Zurich, Switzerland
      More by Sotiris E. Pratsinis
    • Inge K. Herrmann*
      Inge K. Herrmann
      Laboratory for Particles-Biology Interactions, Department of Materials Meet Life, Swiss Federal Laboratories for Materials Science and Technology (Empa), Lerchenfeldstrasse 5, CH-9014 St. Gallen, Switzerland
      *E-mail: [email protected]. Phone: +41 (0)58 765 71 53.
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      Orcidhttp://orcid.org/0000-0002-3018-6796
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    ACS Applied Materials & Interfaces

    Cite this: ACS Appl. Mater. Interfaces 2019, 11, 3, 2830–2839
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    https://doi.org/10.1021/acsami.8b18778
    Published December 20, 2018
    Copyright © 2018 American Chemical Society
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    Abstract

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    Despite its use as a highly efficient and reusable catalyst in research and industrial settings, cerium oxide nanoparticles or nanoceria have yet to gain a foothold in the biomedical field. A variety of beneficial effects of nanoceria have been demonstrated, including its use as an inorganic nanoenzyme to mimic antioxidant enzymes, to protect mammalian cells, and to suppress microbial growth. While these properties are of high interest for wound-management applications, the literature offers contradicting reports on toxicity and enzymatic activity of nanoceria. These discrepancies can be attributed to differences between synthesis methods and insufficient physicochemical characterization, leading to incomparable studies. The activity of nanoceria is mostly governed by its Ce3+/Ce4+ ratio which needs to be controlled to compare different nanoceria systems. In this work, we demonstrate that liquid-feed flame spray pyrolysis offers excellent control over the oxidation state in a one-step synthesis of nanoceria. This control allows a comprehensive comparison of different types of ceria nanoparticles. We connect physicochemical characteristics to biomedically relevant properties such as superoxide dismutase and catalase mimicry, human monocyte and macrophage protection, and antimicrobial activity. Furthermore, we demonstrate how the synthesis method also allows tailoring the properties of ceria/bioglass hybrid nanoparticles, thus creating nanoparticles with manifold biomedical prospects.

    Copyright © 2018 American Chemical Society

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    Supporting Information

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    The Supporting Information is available free of charge on the ACS Publications website at DOI: 10.1021/acsami.8b18778.

    • Schematics of the liquid-feed flame spray reactor setup used for the two types of ceria/bioglass hybrid nanoparticles; scanning electron transmission micrographs and EDXS spectra of CeO2/bioglass hybrids; list of synthesized nanoparticles with corresponding synthesis conditions, crystalline sizes, and Raman peak intensity ratios; comparison of the XRD crystalline size of nanoparticles in this work and others; pooled results from cytotoxicity and cytoprotectivity assays; intracellular H2DCF oxidation measurements to estimate ROS scavenging activity; and bacterial viability measurements using resazurin (PDF)

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    ACS Applied Materials & Interfaces

    Cite this: ACS Appl. Mater. Interfaces 2019, 11, 3, 2830–2839
    Click to copy citationCitation copied!
    https://doi.org/10.1021/acsami.8b18778
    Published December 20, 2018
    Copyright © 2018 American Chemical Society
    Request reuse permissions

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