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Multidomain-Based Responsive Materials with Dual-Mode Optical Readouts

  • Yil-Hwan You
    Yil-Hwan You
    Department of Materials Science and Engineering, Texas A&M University, College Station, Texas 77843, United States
    More by Yil-Hwan You
  • Aniket Biswas
    Aniket Biswas
    Department of Biomedical Engineering, Texas A&M University, College Station, Texas 77843, United States
  • Ashvin T. Nagaraja
    Ashvin T. Nagaraja
    Department of Biomedical Engineering, Texas A&M University, College Station, Texas 77843, United States
  • Jin-Ha Hwang
    Jin-Ha Hwang
    Department of Materials Science and Engineering, Hongik University, 121-791 Seoul, South Korea
    More by Jin-Ha Hwang
  • Gerard L. Coté
    Gerard L. Coté
    Department of Biomedical Engineering, Texas A&M University, College Station, Texas 77843, United States
    Center for Remote Health Technologies & Systems, Texas A&M Engineering Experiment Station, College Station, Texas 77840, United States
  • , and 
  • Michael J. McShane*
    Michael J. McShane
    Department of Materials Science and Engineering  and  Department of Biomedical Engineering, Texas A&M University, College Station, Texas 77843, United States
    Center for Remote Health Technologies & Systems, Texas A&M Engineering Experiment Station, College Station, Texas 77840, United States
    *E-mail: [email protected]. Phone 979-845-7941. Fax 979-845-4450.
Cite this: ACS Appl. Mater. Interfaces 2019, 11, 15, 14286–14295
Publication Date (Web):March 25, 2019
https://doi.org/10.1021/acsami.8b21861
Copyright © 2019 American Chemical Society

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    Abstract

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    Responsive materials designed to generate signals for both surface-enhanced Raman spectroscopy (SERS) and phosphorescence lifetime—“dual-mode”—measurements are described. To demonstrate this concept, we incorporated pH-sensitive and oxygen-sensitive microdomains into a single hydrogel that could be interrogated via SERS and phosphorescence lifetime, respectively. Microdomains consisted two populations of discrete microcapsules containing either (1) gold nanoparticles capped with pH-sensitive Raman molecules or (2) oxygen-sensitive benzoporphyrin phosphors. While the microdomain-embedded hydrogels presented an expected background luminescence, the pH-sensitive SERS signal was distinguishable for all tested conditions. Response characteristics of the dual sensor showed no significant difference when compared to standalone single-mode pH and oxygen sensors. In addition, the feasibility of redundant multimode sensing was proven by observing the reaction produced by glucose oxidase chemically cross-linked within the corresponding alginate matrix. Each optical mode showed a signal change proportional to glucose concentration with an opposite signal directionality. These results support the promise of micro-/nanocomposite materials to improve measurement accuracy using intrinsic multimode responses and built-in redundancy, concepts that have broad appeal in the chemical sensing and biosensing fields.

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    The Supporting Information is available free of charge on the ACS Publications website at DOI: 10.1021/acsami.8b21861.

    • Alginate hydrogel mold, size distribution of AuNPs calculated from TEM data, zeta potentials of citrate-AuNPs and MBA-AuNPs, EDS spectra of a PEM MP, BSE images of PEM MPs, and XRD data of PEM MPsPDF

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