Hyaluronate–Gold Nanoparticle/Glucose Oxidase Complex for Highly Sensitive Wireless Noninvasive Glucose SensorsClick to copy article linkArticle link copied!
- Su-Kyoung KimSu-Kyoung KimDepartment of Materials Science and Engineering, Pohang University of Science and Technology (POSTECH), 77 Cheongam-ro, Nam-gu, Pohang 790-784, Gyeongbuk, KoreaMore by Su-Kyoung Kim
- Cheonhoo JeonCheonhoo JeonDepartment of Electrical Engineering, Pohang University of Science and Technology (POSTECH), 77 Cheongam-ro, Nam-gu, Pohang 37673, Gyeongbuk, KoreaMore by Cheonhoo Jeon
- Geon-Hui LeeGeon-Hui LeeDepartment of Materials Science and Engineering, Pohang University of Science and Technology (POSTECH), 77 Cheongam-ro, Nam-gu, Pohang 790-784, Gyeongbuk, KoreaMore by Geon-Hui Lee
- Jahyun KooJahyun KooDepartment of Electrical Engineering, Pohang University of Science and Technology (POSTECH), 77 Cheongam-ro, Nam-gu, Pohang 37673, Gyeongbuk, KoreaMore by Jahyun Koo
- Seong Hwi ChoSeong Hwi ChoDepartment of Materials Science and Engineering, Pohang University of Science and Technology (POSTECH), 77 Cheongam-ro, Nam-gu, Pohang 790-784, Gyeongbuk, KoreaMore by Seong Hwi Cho
- Seulgi HanSeulgi HanDepartment of Materials Science and Engineering, Pohang University of Science and Technology (POSTECH), 77 Cheongam-ro, Nam-gu, Pohang 790-784, Gyeongbuk, KoreaMore by Seulgi Han
- Myeong-Hwan ShinMyeong-Hwan ShinDepartment of Materials Science and Engineering, Pohang University of Science and Technology (POSTECH), 77 Cheongam-ro, Nam-gu, Pohang 790-784, Gyeongbuk, KoreaMore by Myeong-Hwan Shin
- Jae-Yoon Sim*Jae-Yoon Sim*E-mail: [email protected]. Tel: +82 54 279 2378. Fax: +82 54 279 2903 (J.-Y.S.).Department of Electrical Engineering, Pohang University of Science and Technology (POSTECH), 77 Cheongam-ro, Nam-gu, Pohang 37673, Gyeongbuk, KoreaMore by Jae-Yoon Sim
- Sei Kwang Hahn*Sei Kwang Hahn*E-mail: [email protected]. Tel: +82 54 279 2159. Fax: +82 54 279 2399 (S.K.H.).Department of Materials Science and Engineering, Pohang University of Science and Technology (POSTECH), 77 Cheongam-ro, Nam-gu, Pohang 790-784, Gyeongbuk, KoreaPHI BIOMED Co., #613, 12 Gangnam-daero 65-gil, Seocho-gu, Seoul 06612, KoreaMore by Sei Kwang Hahn
Abstract

Noninvasive real-time biosensors to measure glucose levels in the body fluids have been widely investigated for continuous glucose monitoring of diabetic patients. However, they suffered from low sensitivity and reproducibility due to the instability of nanomaterials used for glucose biosensors. Here, we developed a hyaluronate–gold nanoparticle/glucose oxidase (HA–AuNP/GOx) complex and an ultralow-power application-specific integrated circuit chip for noninvasive and robust wireless patch-type glucose sensors. The HA–AuNP/GOx complex was prepared by the facile conjugation of thiolated HA to AuNPs and the following physical binding of GOx. The wireless glucose sensor exhibited slow water evaporation (0.11 μL/min), fast response (5 s), high sensitivity (12.37 μA·dL/mg·cm2) and selectivity, a low detection limit (0.5 mg/dL), and highly stable enzymatic activity (∼14 days). We successfully demonstrated the strong correlation between glucose concentrations measured by a commercially available blood glucometer and the wireless patch-type glucose sensor. Taken together, we could confirm the feasibility of the wireless patch-type robust glucose sensor for noninvasive and continuous diabetic diagnosis.
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