ACS Publications. Most Trusted. Most Cited. Most Read
My Activity
Recently Viewed
You have not visited any articles yet, Please visit some articles to see contents here.
CONTENT TYPES

Figure 1Loading Img

Functionalized Germanene-Based Nanomaterials for the Detection of Single Nucleotide Polymorphism

  • Zhen Song
    Zhen Song
    Division of Chemistry & Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, 637371, Singapore
    Key Laboratory of Optic-Electric Sensing and Analytical Chemistry for Life Science, MOE, Shandong Key Laboratory of Biochemical Analysis, Key Laboratory of Analytical Chemistry for Life Science in Universities of Shandong, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, P. R. China
    More by Zhen Song
  • Wei Li Ang
    Wei Li Ang
    Division of Chemistry & Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, 637371, Singapore
    More by Wei Li Ang
  • Jiri Sturala
    Jiri Sturala
    Department of Inorganic Chemistry, University of Chemistry and Technology Prague, Technická 5, 166 28 Prague 6, Czech Republic
    More by Jiri Sturala
  • Vlastimil Mazanek
    Vlastimil Mazanek
    Department of Inorganic Chemistry, University of Chemistry and Technology Prague, Technická 5, 166 28 Prague 6, Czech Republic
  • Petr Marvan
    Petr Marvan
    Department of Inorganic Chemistry, University of Chemistry and Technology Prague, Technická 5, 166 28 Prague 6, Czech Republic
    More by Petr Marvan
  • Zdeněk Sofer
    Zdeněk Sofer
    Department of Inorganic Chemistry, University of Chemistry and Technology Prague, Technická 5, 166 28 Prague 6, Czech Republic
  • Adriano Ambrosi
    Adriano Ambrosi
    Key Laboratory of Optic-Electric Sensing and Analytical Chemistry for Life Science, MOE, Shandong Key Laboratory of Biochemical Analysis, Key Laboratory of Analytical Chemistry for Life Science in Universities of Shandong, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, P. R. China
  • Caifeng Ding
    Caifeng Ding
    Key Laboratory of Optic-Electric Sensing and Analytical Chemistry for Life Science, MOE, Shandong Key Laboratory of Biochemical Analysis, Key Laboratory of Analytical Chemistry for Life Science in Universities of Shandong, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, P. R. China
    More by Caifeng Ding
  • Xiliang Luo*
    Xiliang Luo
    Key Laboratory of Optic-Electric Sensing and Analytical Chemistry for Life Science, MOE, Shandong Key Laboratory of Biochemical Analysis, Key Laboratory of Analytical Chemistry for Life Science in Universities of Shandong, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, P. R. China
    *X.L.: email, [email protected]
    More by Xiliang Luo
  • , and 
  • Alessandra Bonanni*
    Alessandra Bonanni
    Division of Chemistry & Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, 637371, Singapore
    Key Laboratory of Optic-Electric Sensing and Analytical Chemistry for Life Science, MOE, Shandong Key Laboratory of Biochemical Analysis, Key Laboratory of Analytical Chemistry for Life Science in Universities of Shandong, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, P. R. China
    *A.B.: email, [email protected]
Cite this: ACS Appl. Nano Mater. 2021, 4, 5, 5164–5175
Publication Date (Web):May 19, 2021
https://doi.org/10.1021/acsanm.1c00606
Copyright © 2021 American Chemical Society
Article Views
588
Altmetric
-
Citations
LEARN ABOUT THESE METRICS
Read OnlinePDF (4 MB)
Supporting Info (1)»

Abstract

Abstract Image

2D monoelemental materials beyond graphene, such as germanene, have recently garnered extensive attention due to their tunable optical and electronic properties. While the performance of germanene-based materials, for example, germanane, for energy storage and catalysis applications has been previously examined, to the best of our knowledge their use for electrochemical biosensing has yet to be widely explored. To this aim, a disposable genosensor, with three different types of nanosized germananes, namely, germanane, methylgermanane, and cyanopropylgermanane, is proposed here for the sensitive and selective detection of Alzheimer-related single nucleotide polymorphism (SNP) using electrochemical impedance spectroscopy. Among the three materials, germanane enabled excellent bioanalytical performance and showcased rapid electron transfer rates for the detection of SNP, providing a linear range between 1 × 10–12 and 1 × 10–8 M and with a detection limit of 34 pM under optimized conditions. Moreover, the potential of the developed device for miniaturization and decentralized analysis is demonstrated with the use of a disposable electrode printed chip (DEP-chip). This study not only demonstrated the potential use of germanene-based nanomaterials as a biosensing platform but also provided a platform to tailor their chemical features to achieve the optimal biosensing performance.

Supporting Information

ARTICLE SECTIONS
Jump To

The Supporting Information is available free of charge at https://pubs.acs.org/doi/10.1021/acsanm.1c00606.

  • Additional XPS figures, FTIR, Raman, and XRD characterization figures, TGA spectra, AFM images, UV–vis spectra, hybridization temperature optimization, and Randles equivalent circuit (PDF)

Terms & Conditions

Most electronic Supporting Information files are available without a subscription to ACS Web Editions. Such files may be downloaded by article for research use (if there is a public use license linked to the relevant article, that license may permit other uses). Permission may be obtained from ACS for other uses through requests via the RightsLink permission system: http://pubs.acs.org/page/copyright/permissions.html.

Cited By

This article is cited by 1 publications.

  1. Eugenio Cinquanta, Samim Sardar, Warren L. B. Huey, Caterina Vozzi, Joshua E. Goldberger, Cosimo D’Andrea, Christoph Gadermaier. Dynamics of Two Distinct Exciton Populations in Methyl-Functionalized Germanane. Nano Letters 2022, 22 (3) , 1183-1189. https://doi.org/10.1021/acs.nanolett.1c04357

Pair your accounts.

Export articles to Mendeley

Get article recommendations from ACS based on references in your Mendeley library.

Pair your accounts.

Export articles to Mendeley

Get article recommendations from ACS based on references in your Mendeley library.

You’ve supercharged your research process with ACS and Mendeley!

STEP 1:
Click to create an ACS ID

Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

MENDELEY PAIRING EXPIRED
Your Mendeley pairing has expired. Please reconnect

This website uses cookies to improve your user experience. By continuing to use the site, you are accepting our use of cookies. Read the ACS privacy policy.

CONTINUE