Functionalized Germanene-Based Nanomaterials for the Detection of Single Nucleotide Polymorphism
- Zhen SongZhen SongDivision of Chemistry & Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, 637371, SingaporeKey Laboratory of Optic-Electric Sensing and Analytical Chemistry for Life Science, MOE, Shandong Key Laboratory of Biochemical Analysis, Key Laboratory of Analytical Chemistry for Life Science in Universities of Shandong, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, P. R. ChinaMore by Zhen Song,
- Wei Li AngWei Li AngDivision of Chemistry & Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, 637371, SingaporeMore by Wei Li Ang,
- Jiri SturalaJiri SturalaDepartment of Inorganic Chemistry, University of Chemistry and Technology Prague, Technická 5, 166 28 Prague 6, Czech RepublicMore by Jiri Sturala,
- Vlastimil MazanekVlastimil MazanekDepartment of Inorganic Chemistry, University of Chemistry and Technology Prague, Technická 5, 166 28 Prague 6, Czech RepublicMore by Vlastimil Mazanek,
- Petr MarvanPetr MarvanDepartment of Inorganic Chemistry, University of Chemistry and Technology Prague, Technická 5, 166 28 Prague 6, Czech RepublicMore by Petr Marvan,
- Zdeněk SoferZdeněk SoferDepartment of Inorganic Chemistry, University of Chemistry and Technology Prague, Technická 5, 166 28 Prague 6, Czech RepublicMore by Zdeněk Sofer,
- Adriano AmbrosiAdriano AmbrosiKey Laboratory of Optic-Electric Sensing and Analytical Chemistry for Life Science, MOE, Shandong Key Laboratory of Biochemical Analysis, Key Laboratory of Analytical Chemistry for Life Science in Universities of Shandong, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, P. R. ChinaMore by Adriano Ambrosi,
- Caifeng DingCaifeng DingKey Laboratory of Optic-Electric Sensing and Analytical Chemistry for Life Science, MOE, Shandong Key Laboratory of Biochemical Analysis, Key Laboratory of Analytical Chemistry for Life Science in Universities of Shandong, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, P. R. ChinaMore by Caifeng Ding,
- Xiliang Luo*Xiliang Luo*X.L.: email, [email protected]Key Laboratory of Optic-Electric Sensing and Analytical Chemistry for Life Science, MOE, Shandong Key Laboratory of Biochemical Analysis, Key Laboratory of Analytical Chemistry for Life Science in Universities of Shandong, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, P. R. ChinaMore by Xiliang Luo, and
- Alessandra Bonanni*Alessandra Bonanni*A.B.: email, [email protected]Division of Chemistry & Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, 637371, SingaporeKey Laboratory of Optic-Electric Sensing and Analytical Chemistry for Life Science, MOE, Shandong Key Laboratory of Biochemical Analysis, Key Laboratory of Analytical Chemistry for Life Science in Universities of Shandong, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, P. R. ChinaMore by Alessandra Bonanni
Abstract
2D monoelemental materials beyond graphene, such as germanene, have recently garnered extensive attention due to their tunable optical and electronic properties. While the performance of germanene-based materials, for example, germanane, for energy storage and catalysis applications has been previously examined, to the best of our knowledge their use for electrochemical biosensing has yet to be widely explored. To this aim, a disposable genosensor, with three different types of nanosized germananes, namely, germanane, methylgermanane, and cyanopropylgermanane, is proposed here for the sensitive and selective detection of Alzheimer-related single nucleotide polymorphism (SNP) using electrochemical impedance spectroscopy. Among the three materials, germanane enabled excellent bioanalytical performance and showcased rapid electron transfer rates for the detection of SNP, providing a linear range between 1 × 10–12 and 1 × 10–8 M and with a detection limit of 34 pM under optimized conditions. Moreover, the potential of the developed device for miniaturization and decentralized analysis is demonstrated with the use of a disposable electrode printed chip (DEP-chip). This study not only demonstrated the potential use of germanene-based nanomaterials as a biosensing platform but also provided a platform to tailor their chemical features to achieve the optimal biosensing performance.
Cited By
This article is cited by 1 publications.
- Eugenio Cinquanta, Samim Sardar, Warren L. B. Huey, Caterina Vozzi, Joshua E. Goldberger, Cosimo D’Andrea, Christoph Gadermaier. Dynamics of Two Distinct Exciton Populations in Methyl-Functionalized Germanane. Nano Letters 2022, 22 (3) , 1183-1189. https://doi.org/10.1021/acs.nanolett.1c04357