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Biocompatible Degradable Hollow Nanoparticles from Curable Copolymers of Polylactic Acid for UV-Shielding Cosmetics

  • Kamonchanok Thananukul
    Kamonchanok Thananukul
    School of Bio-Chemical Engineering and Technology, Sirindhorn International Institute of Technology (SIIT), Thammasat University, Khlong Luang, Pathum Thani 12121, Thailand
  • Chariya Kaewsaneha
    Chariya Kaewsaneha
    School of Bio-Chemical Engineering and Technology, Sirindhorn International Institute of Technology (SIIT), Thammasat University, Khlong Luang, Pathum Thani 12121, Thailand
  • Paiboon Sreearunothai
    Paiboon Sreearunothai
    School of Bio-Chemical Engineering and Technology, Sirindhorn International Institute of Technology (SIIT), Thammasat University, Khlong Luang, Pathum Thani 12121, Thailand
  • Atitsa Petchsuk
    Atitsa Petchsuk
    National Metal and Materials Technology Center, National Science and Technology Development Agency, Khlong Luang, Pathum Thani 12120, Thailand
  • Suthawan Buchatip
    Suthawan Buchatip
    National Metal and Materials Technology Center, National Science and Technology Development Agency, Khlong Luang, Pathum Thani 12120, Thailand
  • Wilairat Supmak
    Wilairat Supmak
    National Metal and Materials Technology Center, National Science and Technology Development Agency, Khlong Luang, Pathum Thani 12120, Thailand
  • Bunthoeun Nim
    Bunthoeun Nim
    School of Bio-Chemical Engineering and Technology, Sirindhorn International Institute of Technology (SIIT), Thammasat University, Khlong Luang, Pathum Thani 12121, Thailand
  • Masayoshi Okubo
    Masayoshi Okubo
    Graduate School of Engineering, Kobe University, Kobe 657-8501, Japan
  • , and 
  • Pakorn Opaprakasit*
    Pakorn Opaprakasit
    School of Bio-Chemical Engineering and Technology, Sirindhorn International Institute of Technology (SIIT), Thammasat University, Khlong Luang, Pathum Thani 12121, Thailand
    *Email: [email protected]
Cite this: ACS Appl. Nano Mater. 2022, 5, 3, 4473–4483
Publication Date (Web):February 24, 2022
https://doi.org/10.1021/acsanm.2c00606
Copyright © 2022 American Chemical Society

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    Abstract

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    Hollow polymeric nanoparticles have attracted vast attention as UV-shielding materials in personal care products due to their excellent light scattering characteristics and low density. In this work, a process for fabricating biocompatible/degradable poly(lactic acid-co-glycidyl methacrylate), P(LA-co-GMA), hollow nanoparticles via one-step phase inversion emulsification is examined, to gain insights into their formation mechanisms and optimization of the process parameters. The migration of poly(vinyl alcohol) (PVA) (stabilizing agent) from the oil droplet to the oil/water interface while entangled with cross-linked P(LA-co-GMA) chains and the fast evaporation rate of the chloroform solvent play an essential role in the hollow structure formation. Under optimum conditions, monodispersed hollow nanoparticles, with an average size of 500–700 nm and good colloidal stability, are obtained. The as-prepared hollow nanoparticles exhibit high UV shielding capabilities and low toxicity. The nanoparticles show high stability under UV exposure but can be completely degraded within 24 weeks under accelerated hydrolysis conditions. The materials have a high potential for use as environmental-friendly UV-shielding additives in cosmetic applications.

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    The Supporting Information is available free of charge at https://pubs.acs.org/doi/10.1021/acsanm.2c00606.

    • XPS spectra of the P(LA-co-GMA) copolymer, hollow P(LA-co-GMA) nanoparticles prepared using a PVA stabilizing agent in the oil phase at 3 wt % (3PVA) and 5 wt % (5PVA) and PVA dissolved in the SDS aqueous phase at 3 wt % (PVA in aqueous phase), elemental composition results derived from XPS spectra, ATR-FTIR spectra of the neat P(LA-co-GMA) copolymer, hollow P(LA-co-GMA) nanoparticles prepared by using the PVA stabilizing agent in the oil phase at 3 wt % (3PVA), SDS, and PVA, and UV–vis spectra of neat PVA and P(LA-co-GMA) films (PDF)

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    Cited By

    This article is cited by 1 publications.

    1. Bunthoeurn Khann, Duangporn Polpanich, Pakorn Opaprakasit, Yodsathorn Wongngam, Kamonchanok Thananukul, Chariya Kaewsaneha. Fabrication of Sacha Inchi Oil-Loaded Microcapsules Employing Natural-Templated Lycopodium clavatum Spores and Their Pressure-Stimuli Release Behavior. ACS Omega 2023, 8 (23) , 20937-20948. https://doi.org/10.1021/acsomega.3c01698

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