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Time-Resolved Study on Self-Assembling Behavior of PEGylated Gold Nanoparticles in the Presence of Human Serum Albumin: A System for Nanomedical Applications
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    Time-Resolved Study on Self-Assembling Behavior of PEGylated Gold Nanoparticles in the Presence of Human Serum Albumin: A System for Nanomedical Applications
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    • Neda Iranpour Anaraki
      Neda Iranpour Anaraki
      Center for X-ray Analytics, Empa, Swiss Federal Laboratories for Materials Science and Technology, Lerchenfeldstrasse 5, St. Gallen 9014, Switzerland
      Laboratory of Particles-Biology Interactions, Empa, Swiss Federal Laboratories for Materials Science and Technology, Lerchenfeldstrasse 5, St. Gallen 9014, Switzerland
      Department of Chemistry, University of Fribourg, Chemin du Musée 9, Fribourg 1700, Switzerland
    • Marianne Liebi
      Marianne Liebi
      Center for X-ray Analytics, Empa, Swiss Federal Laboratories for Materials Science and Technology, Lerchenfeldstrasse 5, St. Gallen 9014, Switzerland
    • Kamran Iranshahi
      Kamran Iranshahi
      Laboratory for Biomimetic Membranes and Textiles, Empa, Swiss Federal Laboratories for Materials Science and Technology, St. Gallen 9014, Switzerland
      Department of Environmental Systems Science, Swiss Federal Institute of Technology, ETH-Zurich, Zurich 8092, Switzerland
    • Clément Blanchet
      Clément Blanchet
      European Molecular Biology Laboratory, Notkestrasse 85, Hamburg 22603, Germany
    • Peter Wick
      Peter Wick
      Laboratory of Particles-Biology Interactions, Empa, Swiss Federal Laboratories for Materials Science and Technology, Lerchenfeldstrasse 5, St. Gallen 9014, Switzerland
      More by Peter Wick
    • Antonia Neels*
      Antonia Neels
      Center for X-ray Analytics, Empa, Swiss Federal Laboratories for Materials Science and Technology, Lerchenfeldstrasse 5, St. Gallen 9014, Switzerland
      Department of Chemistry, University of Fribourg, Chemin du Musée 9, Fribourg 1700, Switzerland
      *Email: [email protected]
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    ACS Applied Nano Materials

    Cite this: ACS Appl. Nano Mater. 2022, 5, 12, 18921–18929
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    https://doi.org/10.1021/acsanm.2c04628
    Published November 23, 2022
    Copyright © 2022 American Chemical Society

    Abstract

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    The combination of a microfluidic approach for synchrotron-based dynamic (early structural changes) with lab-based static small-angle X-ray scattering (SAXS) measurements (longer time scale) allows qualifying nanoparticle (NP) systems for their use in nanomedicine. Time-resolved in situ investigations are performed on self-assembly and colloidal behavior of 5 nm PEGylated (polyethylene glycol) gold NPs in different media. SAXS methods combined with a micromixing fluidic system are used to observe the early stage of NP interactions. Dynamic measurements cover a time range from 1 to 100 s after mixing thoroughly, while static measurements complete the study for up to 10 days after sample preparation. These NPs, after mixing with saline solution (0.9% NaCl solution), self-assemble in 3D ordered domains. The NPs also show this ordering in the presence of human serum albumin (HSA) molecules. It is shown that, although the presence of protein molecules slows down the NP self-assembling process, these molecules improve the long-term colloidal stability of the ordered domains probably via interpolymer complexation between PEG and HSA molecules.

    Copyright © 2022 American Chemical Society

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    Supporting Information

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    The Supporting Information is available free of charge at https://pubs.acs.org/doi/10.1021/acsanm.2c04628.

    • (S2–S3) Values of peak positions, interparticle distance, FWHM, d-spacings, and size of the unit cell of PEGylated gold NPs relative to Figure 4; (S4) Guinier analysis for the NPs - NaCl system; (S5–S10) raw data for all SAXS investigations; (S11) different view angles for SAXS curves; and (S12) superposition of 10 individual measurements for static investigations, day one is monitored (PDF)

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    ACS Applied Nano Materials

    Cite this: ACS Appl. Nano Mater. 2022, 5, 12, 18921–18929
    Click to copy citationCitation copied!
    https://doi.org/10.1021/acsanm.2c04628
    Published November 23, 2022
    Copyright © 2022 American Chemical Society

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