Combination Strategy of Two Hydrogels Loaded with Prussian Blue Nanoparticles and Calcium Peroxide Separately for Diabetic Wound RepairClick to copy article linkArticle link copied!
- Shuo Chai
- Fei Li
- Chunxue ZhangChunxue ZhangCollege of Pharmacy, Qiqihar Medical University, Qiqihar 161006, ChinaMore by Chunxue Zhang
- Tingting LiuTingting LiuCollege of Pharmacy, Qiqihar Medical University, Qiqihar 161006, ChinaMore by Tingting Liu
- Cuiyan Han
- Qi Zhang
- Xiaoyu Sui*Xiaoyu Sui*Email: [email protected]College of Pharmacy, Qiqihar Medical University, Qiqihar 161006, ChinaMore by Xiaoyu Sui
Abstract

Oxidative stress and excessive hypoxia are two key factors hindering diabetic wound healing. Prussian blue nanoparticles (PBNPs) and calcium peroxide (CPO) possess the characteristics of scavenging reactive oxygen species (ROS) and chemically generating oxygen respectively, and both can be used as biomedical materials. However, when the two substances coexist in the aqueous media, Prussian blue undergoes decomposition. In this study, gelatin/carboxymethyl chitosan @PBNP hydrogel and gelatin/carboxymethyl chitosan@CPO hydrogel were prepared separately and combined into concentric circular structures. The results showed that the combination of two hydrogels has good properties for swelling, adhesion, in vitro antioxidant, scavenging intracellular ROS, downregulating tumor necrosis factor-α (TNF-α), and enhancing the proliferation and migration of fibroblasts. In a diabetic mouse wound model, the combined application group shortened wound healing time, promoted growth of granulation tissues, and accelerated collagen formation compared with a single hydrogel treatment. The combined use of the two drug-loaded hydrogels has potential application in promoting diabetic wound repair.
Cited By
This article has not yet been cited by other publications.
Article Views
Altmetric
Citations
Article Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.
Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.
The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated.