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Combination Strategy of Two Hydrogels Loaded with Prussian Blue Nanoparticles and Calcium Peroxide Separately for Diabetic Wound Repair
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    Combination Strategy of Two Hydrogels Loaded with Prussian Blue Nanoparticles and Calcium Peroxide Separately for Diabetic Wound Repair
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    • Shuo Chai
      Shuo Chai
      College of Pharmacy, Qiqihar Medical University, Qiqihar 161006, China
      More by Shuo Chai
    • Fei Li
      Fei Li
      College of Pharmacy, Qiqihar Medical University, Qiqihar 161006, China
      More by Fei Li
    • Chunxue Zhang
      Chunxue Zhang
      College of Pharmacy, Qiqihar Medical University, Qiqihar 161006, China
    • Tingting Liu
      Tingting Liu
      College of Pharmacy, Qiqihar Medical University, Qiqihar 161006, China
      More by Tingting Liu
    • Cuiyan Han
      Cuiyan Han
      College of Pharmacy, Qiqihar Medical University, Qiqihar 161006, China
      More by Cuiyan Han
    • Qi Zhang
      Qi Zhang
      College of Pharmacy, Qiqihar Medical University, Qiqihar 161006, China
      More by Qi Zhang
    • Xiaoyu Sui*
      Xiaoyu Sui
      College of Pharmacy, Qiqihar Medical University, Qiqihar 161006, China
      *Email: [email protected]
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    ACS Applied Nano Materials

    Cite this: ACS Appl. Nano Mater. 2024, 7, 18, 21327–21339
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    https://doi.org/10.1021/acsanm.4c02549
    Published September 9, 2024
    Copyright © 2024 American Chemical Society

    Abstract

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    Oxidative stress and excessive hypoxia are two key factors hindering diabetic wound healing. Prussian blue nanoparticles (PBNPs) and calcium peroxide (CPO) possess the characteristics of scavenging reactive oxygen species (ROS) and chemically generating oxygen respectively, and both can be used as biomedical materials. However, when the two substances coexist in the aqueous media, Prussian blue undergoes decomposition. In this study, gelatin/carboxymethyl chitosan @PBNP hydrogel and gelatin/carboxymethyl chitosan@CPO hydrogel were prepared separately and combined into concentric circular structures. The results showed that the combination of two hydrogels has good properties for swelling, adhesion, in vitro antioxidant, scavenging intracellular ROS, downregulating tumor necrosis factor-α (TNF-α), and enhancing the proliferation and migration of fibroblasts. In a diabetic mouse wound model, the combined application group shortened wound healing time, promoted growth of granulation tissues, and accelerated collagen formation compared with a single hydrogel treatment. The combined use of the two drug-loaded hydrogels has potential application in promoting diabetic wound repair.

    Copyright © 2024 American Chemical Society

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    The Supporting Information is available free of charge at https://pubs.acs.org/doi/10.1021/acsanm.4c02549.

    • The amount of oxygen released from hydrogel during 28 days under 4 °C (PDF)

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    ACS Applied Nano Materials

    Cite this: ACS Appl. Nano Mater. 2024, 7, 18, 21327–21339
    Click to copy citationCitation copied!
    https://doi.org/10.1021/acsanm.4c02549
    Published September 9, 2024
    Copyright © 2024 American Chemical Society

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