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In Situ Forming Silk Sericin-Based Hydrogel: A Novel Wound Healing Biomaterial

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    Tissue Engineering and Regenerative Medicine

    In Situ Forming Silk Sericin-Based Hydrogel: A Novel Wound Healing Biomaterial
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    • Sara Baptista-Silva*
      Sara Baptista-Silva
      Universidade Católica Portuguesa, CBQF—Centro de Biotecnologia e Química Fina—Laboratório Associado, Escola Superior de Biotecnologia, Rua Diogo Botelho 1327, 4169-005 Porto, Portugal
      *Email: [email protected]
      More by Sara Baptista-Silva
      Orcidhttp://orcid.org/0000-0003-1805-144X
    • Sandra Borges
      Sandra Borges
      Universidade Católica Portuguesa, CBQF—Centro de Biotecnologia e Química Fina—Laboratório Associado, Escola Superior de Biotecnologia, Rua Diogo Botelho 1327, 4169-005 Porto, Portugal
      More by Sandra Borges
    • Ana Rita Costa-Pinto
      Ana Rita Costa-Pinto
      Universidade do Porto, i3S—Instituto de Investigação e Inovação em Saúde, Porto 4200-135, Portugal
      More by Ana Rita Costa-Pinto
    • Raquel Costa
      Raquel Costa
      Department of Biomedicine, Faculty of Medicine, University of Porto, Porto 4099-002, Portugal
      More by Raquel Costa
    • Manuela Amorim
      Manuela Amorim
      Universidade Católica Portuguesa, CBQF—Centro de Biotecnologia e Química Fina—Laboratório Associado, Escola Superior de Biotecnologia, Rua Diogo Botelho 1327, 4169-005 Porto, Portugal
      More by Manuela Amorim
    • Juliana R. Dias
      Juliana R. Dias
      Centre for Rapid and Sustainable Product Development, Instituto Politécnico de Leiria, Zona Industrial, Marinha Grande 2430-028, Portugal
      More by Juliana R. Dias
    • Óscar Ramos
      Óscar Ramos
      Universidade Católica Portuguesa, CBQF—Centro de Biotecnologia e Química Fina—Laboratório Associado, Escola Superior de Biotecnologia, Rua Diogo Botelho 1327, 4169-005 Porto, Portugal
      More by Óscar Ramos
    • Paulo Alves
      Paulo Alves
      Centre for Interdisciplinary Research in Health (CIIS)—Wounds Research Lab, Universidade Católica Portuguesa, ICS—Instituto de Ciências da Saúde, Porto 4169-005, Portugal
      More by Paulo Alves
    • Pedro Lopes Granja
      Pedro Lopes Granja
      Universidade do Porto, i3S—Instituto de Investigação e Inovação em Saúde, Porto 4200-135, Portugal
      More by Pedro Lopes Granja
    • Raquel Soares
      Raquel Soares
      Department of Biomedicine, Faculty of Medicine, University of Porto, Porto 4099-002, Portugal
      More by Raquel Soares
      Orcidhttp://orcid.org/0000-0002-9157-5541
    • Manuela Pintado
      Manuela Pintado
      Universidade Católica Portuguesa, CBQF—Centro de Biotecnologia e Química Fina—Laboratório Associado, Escola Superior de Biotecnologia, Rua Diogo Botelho 1327, 4169-005 Porto, Portugal
      More by Manuela Pintado
    • Ana Leite Oliveira*
      Ana Leite Oliveira
      Universidade Católica Portuguesa, CBQF—Centro de Biotecnologia e Química Fina—Laboratório Associado, Escola Superior de Biotecnologia, Rua Diogo Botelho 1327, 4169-005 Porto, Portugal
      *Email: [email protected]
      More by Ana Leite Oliveira
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    ACS Biomaterials Science & Engineering

    Cite this: ACS Biomater. Sci. Eng. 2021, 7, 4, 1573–1586
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    https://doi.org/10.1021/acsbiomaterials.0c01745
    Published March 17, 2021
    Copyright © 2021 American Chemical Society
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    Abstract

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    In situ cross-linked hydrogels have the advantage of effectively fulfilling the wound in its shape and depth. Amongst the new generation of natural-based biopolymers being proposed for wound care and skin regeneration, silk sericin is particularly interesting due to its exceptional properties such as biocompatibility, biodegradability, and antioxidant behavior, among others. In this study, a new enzyme-mediated cross-linked hydrogel composed of silk sericin is proposed for the first time. The developed hydrogel cross-linking strategy was performed via horseradish peroxidase, under physiological conditions, and presented gelling kinetics under 3 min, as demonstrated by its rheological behavior. The hydrogels presented a high degree of transparency, mainly due to their amorphous conformation. Degradation studies revealed that the hydrogels were stable in phosphate buffer solution (PBS) (pH 7.4) for 17 days, while in the presence of protease XIV (3.5 U/mg) and under acute and chronic physiological pH values, the stability decreased to 7 and 4 days, respectively. During protease degradation, the present sericin hydrogels demonstrated antioxidant activity. In vitro studies using an L929 fibroblast cell line demonstrated that these hydrogels were noncytotoxic, promoting cell adhesion and massive cell colonization after 7 days of culture, demonstrating that cells maintained their viability and proliferation. In addition, the application of sericin-based hydrogel in an in vivo diabetic wound model validated the feasibility of the in situ methodology and demonstrated a local anti-inflammatory effect, promoting the healing process. This study presents a simple, fast, and practical in situ approach to produce a sericin-based hydrogel able to be applied in low exudative chronic wounds. Moreover, the study herein reported fosters the valorization of a textile industrial by-product by its integration in the biomedical field.

    Copyright © 2021 American Chemical Society

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    This article is cited by 52 publications.

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    ACS Biomaterials Science & Engineering

    Cite this: ACS Biomater. Sci. Eng. 2021, 7, 4, 1573–1586
    Click to copy citationCitation copied!
    https://doi.org/10.1021/acsbiomaterials.0c01745
    Published March 17, 2021
    Copyright © 2021 American Chemical Society
    Request reuse permissions

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