Pair your accounts.

Export articles to Mendeley

Get article recommendations from ACS based on references in your Mendeley library.

Pair your accounts.

Export articles to Mendeley

Get article recommendations from ACS based on references in your Mendeley library.

You’ve supercharged your research process with ACS and Mendeley!

STEP 1:
Click to create an ACS ID

Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

MENDELEY PAIRING EXPIRED
Your Mendeley pairing has expired. Please reconnect
ACS Publications. Most Trusted. Most Cited. Most Read
Oriented Crystallization of Hydroxyapatite in Self-Assembled Peptide Fibrils as a Bonelike Material

OR SEARCH CITATIONS

My Activity
Publications

Figure 1Loading Img
Download Hi-Res ImageDownload to MS-PowerPointCite This:ACS Biomater. Sci. Eng. 2023, 9, 4, 1808-1814
    Article

    Oriented Crystallization of Hydroxyapatite in Self-Assembled Peptide Fibrils as a Bonelike Material
    Click to copy article linkArticle link copied!

    • Changyu Shao
      Changyu Shao
      Qiushi Academy for Advanced Studies, Zhejiang University, Hangzhou 310027, China
      Department of Chemistry, Zhejiang University, Hangzhou 310027, China
      More by Changyu Shao
    • Zhisen Zhang
      Zhisen Zhang
      College of Physical Science and Technology, Xiamen University, Xiamen 361005, China
      More by Zhisen Zhang
      Orcidhttps://orcid.org/0000-0002-8638-0993
    • Wenjing Jin
      Wenjing Jin
      Affiliated Hospital of Stomatology, School of Stomatology, Zhejiang University School of Medicine and Key Laboratory of Oral Biomedical Research of Zhejiang Province, Hangzhou 310006, China
      More by Wenjing Jin
    • Zhan Zhang
      Zhan Zhang
      Department of Orthopedics, Tongde Hospital of Zhejiang Province, Hangzhou 310012, China
      More by Zhan Zhang
    • Biao Jin
      Biao Jin
      Department of Chemistry, Zhejiang University, Hangzhou 310027, China
      More by Biao Jin
    • Shuqin Jiang
      Shuqin Jiang
      Qiushi Academy for Advanced Studies, Zhejiang University, Hangzhou 310027, China
      More by Shuqin Jiang
    • Haihua Pan*
      Haihua Pan
      Qiushi Academy for Advanced Studies, Zhejiang University, Hangzhou 310027, China
      *Phone: +86 183-5719-6218; E-mail: [email protected]
      More by Haihua Pan
    • Ruikang Tang*
      Ruikang Tang
      Department of Chemistry, Zhejiang University, Hangzhou 310027, China
      *Phone: +86 571-8795-3736; E-mail: [email protected]
      More by Ruikang Tang
      Orcidhttps://orcid.org/0000-0001-5277-7338
    • James J. De Yoreo
      James J. De Yoreo
      Physical Sciences Division, Pacific Northwest National Laboratory, Richland, Washington 99354, United States
      More by James J. De Yoreo
      Orcidhttps://orcid.org/0000-0002-9194-6699
    • Xiang Yang Liu*
      Xiang Yang Liu
      College of Ocean and Earth Sciences, Xiamen University, Xiamen 361102, China
      *Phone: +86 189-5928-1839; E-mail: [email protected]
      More by Xiang Yang Liu
    Other Access OptionsSupporting Information (1)

    ACS Biomaterials Science & Engineering

    Cite this: ACS Biomater. Sci. Eng. 2023, 9, 4, 1808–1814
    Click to copy citationCitation copied!
    https://doi.org/10.1021/acsbiomaterials.1c00713
    Published December 2, 2021
    Copyright © 2021 American Chemical Society
    Request reuse permissions

    Abstract

    Click to copy section linkSection link copied!
    Abstract Image

    Controlling oriented crystallization is key to producing bonelike composite materials with a well-organized structure. However, producing this type of composite material using synthetic biopolymers as scaffolds is challenging. Inspired by the molecular structure of collagen-I, a collagenlike peptide─(Pro-Hyp-Gly)10 (POG10)─was designed to produce self-assembled fibrils that resemble the structure of collagen-I fibrils. In addition, the oriented mineralization of HAP crystals is formed in the fibrils that reproduces a bonelike material similar to collagen-I fibril mineralization. Unlike collagen-I fibrils, POG10 fibrils do not contain gap spaces. The molecular simulation results indicate that in addition to space confinement, the molecular field generated by POG10 can also confine the orientation of HAP, enriching our understanding of physical confinement and shedding light on the design of synthetic biopolymer scaffolds for bonelike material fabrication.

    Copyright © 2021 American Chemical Society

    Keywords

    what are keywords

    Read this article

    To access this article, please review the available access options below.

    Get instant access

    Purchase Access

    Read this article for 48 hours. Check out below using your ACS ID or as a guest.

    Recommended

    Access through Your Institution

    You may have access to this article through your institution.

    Your institution does not have access to this content. Add or change your institution or let them know you’d like them to include access.

    Supporting Information

    Click to copy section linkSection link copied!

    The Supporting Information is available free of charge at https://pubs.acs.org/doi/10.1021/acsbiomaterials.1c00713.

    • Figure S1: AFM image of self-assembled POG10 fibrils. Figure S2: TEM image of collagen-I fibrils. Figure S3: TEM image of the collagen-I fibrils after mineralization for 6 h. Figure S4: Umbrella sampling windows for free energy calculations. Figure S5: Calculation of orientation function (PDF)

    Terms & Conditions

    Most electronic Supporting Information files are available without a subscription to ACS Web Editions. Such files may be downloaded by article for research use (if there is a public use license linked to the relevant article, that license may permit other uses). Permission may be obtained from ACS for other uses through requests via the RightsLink permission system: http://pubs.acs.org/page/copyright/permissions.html.

    Cited By

    Click to copy section linkSection link copied!

    This article is cited by 2 publications.

    1. Ruikang Tang, (Guest Editor, Zhejiang University)Michio Suzuki (Guest Editor, The University of Tokyo). Special Issue on Biomineralization: From Principles to Practices. ACS Biomaterials Science & Engineering 2023, 9 (4) , 1730-1732. https://doi.org/10.1021/acsbiomaterials.3c00258
    2. Hao Kong, Guozheng Yang, Peng He, Danzhu Zhu, Xin Luan, Youyin Xu, Rongqiu Mu, Gang Wei. Self-assembly of bioinspired peptides for biomimetic synthesis of advanced peptide-based nanomaterials: a mini-review. Nano Futures 2023, 7 (1) , 012001. https://doi.org/10.1088/2399-1984/acafbe
    Download PDF
    Go to ACS Biomaterials Science & Engineering
    Get e-Alerts
    Get e-Alerts

    ACS Biomaterials Science & Engineering

    Cite this: ACS Biomater. Sci. Eng. 2023, 9, 4, 1808–1814
    Click to copy citationCitation copied!
    https://doi.org/10.1021/acsbiomaterials.1c00713
    Published December 2, 2021
    Copyright © 2021 American Chemical Society
    Request reuse permissions

    Article Views

    1107

    Altmetric

    -

    Citations

    2
    Learn about these metrics

    Article Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.

    Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.

    The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated.