Injectable Erythrocyte Gel Loaded with Bulleyaconitine A for the Treatment of Rheumatoid ArthritisClick to copy article linkArticle link copied!
- Hao ChenHao ChenDepartment of Orthopedics, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu215004, ChinaDepartment of Orthopedics, The Affiliated Suqian Hospital of Xuzhou Medical University, Suqian, Jiangsu223800, ChinaInstitute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-based Functional Materials and Devices, Soochow University, Suzhou, Jiangsu215123, ChinaMore by Hao Chen
- Bo TianBo TianDepartment of Orthopedics, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu215004, ChinaMore by Bo Tian
- Xiyao FangXiyao FangDepartment of Orthopedics, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu215004, ChinaMore by Xiyao Fang
- Jinyu Bai*Jinyu Bai*Jinyu Bai email: [email protected]Department of Orthopedics, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu215004, ChinaMore by Jinyu Bai
- Qingle MaQingle MaInstitute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-based Functional Materials and Devices, Soochow University, Suzhou, Jiangsu215123, ChinaMore by Qingle Ma
- Yue ZhangYue ZhangInstitute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-based Functional Materials and Devices, Soochow University, Suzhou, Jiangsu215123, ChinaMore by Yue Zhang
- Jialu XuJialu XuInstitute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-based Functional Materials and Devices, Soochow University, Suzhou, Jiangsu215123, ChinaMore by Jialu Xu
- Beilei WangBeilei WangInstitute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-based Functional Materials and Devices, Soochow University, Suzhou, Jiangsu215123, ChinaMore by Beilei Wang
- Qin FanQin FanInstitute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-based Functional Materials and Devices, Soochow University, Suzhou, Jiangsu215123, ChinaMore by Qin Fan
- Ziying FeiZiying FeiInstitute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-based Functional Materials and Devices, Soochow University, Suzhou, Jiangsu215123, ChinaMore by Ziying Fei
- Huaxing DaiHuaxing DaiInstitute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-based Functional Materials and Devices, Soochow University, Suzhou, Jiangsu215123, ChinaMore by Huaxing Dai
- Huajian ShanHuajian ShanDepartment of Orthopedics, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu215004, ChinaMore by Huajian Shan
- Xiang GaoXiang GaoDepartment of Orthopedics, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu215004, ChinaMore by Xiang Gao
- Qirong DongQirong DongDepartment of Orthopedics, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu215004, ChinaMore by Qirong Dong
- Chao Wang*Chao Wang*Chao Wang email: [email protected]Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-based Functional Materials and Devices, Soochow University, Suzhou, Jiangsu215123, ChinaMore by Chao Wang
- Xiaozhong Zhou*Xiaozhong Zhou*Xiaozhong Zhou email: [email protected]Department of Orthopedics, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu215004, ChinaMore by Xiaozhong Zhou
Abstract
Rheumatoid arthritis (RA) is a systemic autoimmune disease with clinical manifestations including joint cartilage, synovitis, and bone damage. Here we developed an injectable erythrocyte gel loaded with Bulleyaconitine A (BLA) for the treatment of RA and demonstrated its anti-inflammatory effects in vivo and in vitro. In vitro experiments showed that BLA could effectively down-regulate the expression of pro-inflammatory factor in activated macrophages through the nuclear factor-κB (NF-κB) pathway. In vivo experiments have shown that the injection of BLA@RBCs in the inflammatory joints of CIA mice increases the local concentration of BLA in a long time. Improved therapeutic outcomes and reduced toxicity of BLA are demonstrated in our work. Together, the developed BLA@RBCs drug delivery system provides an alternative strategy to treat RA joints and shows high potential in clinical RA treatment.
Cited By
This article is cited by 9 publications.
- Yitong Chen, Yue Zhang, Beilei Wang, Qin Fan, Qianyu Yang, Jialu Xu, Huaxing Dai, Fang Xu, Chao Wang. Blood Clot Scaffold Loaded with Liposome Vaccine and siRNAs Targeting PD-L1 and TIM-3 for Effective DC Activation and Cancer Immunotherapy. ACS Nano 2023, 17
(1)
, 760-774. https://doi.org/10.1021/acsnano.2c10797
- Ruoyu Huang, Qiuyu Pang, Lexin Zheng, Rui Duan, Ying Wang, Zhiyong Wang, Tao Wang. Acute aconitine poisoning resulting from the ingestion of medicinal liquor. Journal of Forensic Sciences 2024, 69
(6)
, 2317-2324. https://doi.org/10.1111/1556-4029.15621
- Andrea Bezze, Carlotta Mattioda, Gianluca Ciardelli, Clara Mattu. Harnessing cells to improve transport of nanomedicines. European Journal of Pharmaceutics and Biopharmaceutics 2024, 203 , 114446. https://doi.org/10.1016/j.ejpb.2024.114446
- Shile Wang, Kehui Li, Yaxin Deng, Jingxin Gou, Haibing He, Tian Yin, Xing Tang, Mohamed El-Shazly, Yu Zhang. Long-acting bulleyaconitine A microspheres via intra-articular delivery for multidimensional therapy of rheumatoid arthritis. International Journal of Pharmaceutics 2024, 661 , 124414. https://doi.org/10.1016/j.ijpharm.2024.124414
- Ying Zhang, Hua Zhou, Xu Chen, Ningning Wang, Yunfei Zhan, Ziyi Huang, Kaiyi Ruan, Qiulan Qi, Min Deng, Yuxin Jiang. A novel tRNA-derived fragment tRF-3023b suppresses inflammation in RAW264.7 cells by targeting Cul4a through NF-κB signaling. Functional & Integrative Genomics 2024, 24
(1)
https://doi.org/10.1007/s10142-024-01285-3
- Mirza Muhammad Faran Ashraf Baig, Lee Ki Wong, Abdul Wasy Zia, Hongkai Wu. Development of biomedical hydrogels for rheumatoid arthritis treatment. Asian Journal of Pharmaceutical Sciences 2024, 19
(1)
, 100887. https://doi.org/10.1016/j.ajps.2024.100887
- Gelin Xiang, Nan Xing, Shaohui Wang, Yi Zhang. Antitumor effects and potential mechanisms of aconitine based on preclinical studies: an updated systematic review and meta-analysis. Frontiers in Pharmacology 2023, 14 https://doi.org/10.3389/fphar.2023.1172939
- Zhiqiang Luo, Lingyu Sun, Feika Bian, Yu Wang, Yunru Yu, Zhuxiao Gu, Yuanjin Zhao. Erythrocyte‐Inspired Functional Materials for Biomedical Applications. Advanced Science 2023, 10
(6)
https://doi.org/10.1002/advs.202206150
- Aida Calderon-Rivera, Santiago Loya-Lopez, Kimberly Gomez, Rajesh Khanna. Plant and fungi derived analgesic natural products targeting voltage-gated sodium and calcium channels. Channels 2022, 16
(1)
, 198-215. https://doi.org/10.1080/19336950.2022.2103234
Article Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.
Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.
The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated.