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Patternable Gelatin Methacrylate/PEDOT/Polystyrene Sulfonate Microelectrode Coatings for Neuronal Recording

  • Mahima Bansal
    Mahima Bansal
    School of Pharmacy, Faculty of Medical and Health Sciences, The University of Auckland, Auckland 1023, New Zealand
  • Yukti Vyas
    Yukti Vyas
    Department of Physiology and Centre for Brain Research, Faculty of Medical and Health Sciences, The University of Auckland, Auckland 1023, New Zealand
    More by Yukti Vyas
  • Zaid Aqrawe
    Zaid Aqrawe
    Department of Anatomy and Medical Imaging, Faculty of Medical and Health Sciences, The University of Auckland, Auckland 1023, New Zealand
    More by Zaid Aqrawe
  • Brad Raos
    Brad Raos
    School of Pharmacy, Faculty of Medical and Health Sciences, The University of Auckland, Auckland 1023, New Zealand
    More by Brad Raos
  • Ernest Cheah
    Ernest Cheah
    School of Pharmacy, Faculty of Medical and Health Sciences, The University of Auckland, Auckland 1023, New Zealand
    More by Ernest Cheah
  • Johanna Montgomery
    Johanna Montgomery
    Department of Physiology and Centre for Brain Research, Faculty of Medical and Health Sciences, The University of Auckland, Auckland 1023, New Zealand
  • Zimei Wu
    Zimei Wu
    School of Pharmacy, Faculty of Medical and Health Sciences, The University of Auckland, Auckland 1023, New Zealand
    More by Zimei Wu
  • , and 
  • Darren Svirskis*
    Darren Svirskis
    School of Pharmacy, Faculty of Medical and Health Sciences, The University of Auckland, Auckland 1023, New Zealand
    *Email: [email protected]
Cite this: ACS Biomater. Sci. Eng. 2022, 8, 9, 3933–3943
Publication Date (Web):August 17, 2022
https://doi.org/10.1021/acsbiomaterials.2c00231
Copyright © 2022 American Chemical Society

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    Abstract

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    This manuscript addresses the need for new soft biomaterials that can be fabricated on the surface of microelectrodes to reduce the mechanical mismatch between biological tissues and electrodes and improve the performance at the neural interface. By electrochemical polymerization of poly(3,4-dioxythiophene) (PEDOT)/polystyrene sulfonate (PSS) through a gelatin methacrylate (GelMA) hydrogel, we demonstrate the synthesis of a conducting polymer hydrogel (CPH) to meet the performance criteria of bioelectrodes. The hybrid material can be photolithographically patterned and covalently attached to gold microelectrodes, forming an interpenetrating network, as confirmed by infrared spectroscopy. The GelMA/PEDOT/PSS coatings were found to be reversibly electroactive by cyclic voltammetry and had low impedance compared to bare gold and GelMA-coated microelectrodes. The CPH coatings showed impedance at levels similar to conventional PEDOT/PSS coatings at a frequency of 1000 Hz. CPH exhibited electrochemical stability over 1000 CV cycles, and its performance was maintained over 14 days. Biocompatibility of the CPH coatings was confirmed by primary hippocampal neuronal cultures via a neuronal viability assay. The CPH-coated microelectrode arrays (MEAs) successfully recorded neuronal activity from primary hippocampal neuronal cells. The CPH GelMA/PEDOT/PSS is a highly promising coating material to enhance microelectrode performance at the neural interface.

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    Cited By

    This article is cited by 1 publications.

    1. Chun-Ting Liu, Jiashing Yu, Min-Hsuan Lin, Kai-Hsiang Chang, Che-Yu Lin, Nai-Chen Cheng, Po-I Wu, Chun-Wei Huang, Pin-Yu Zhang, Min-Tzu Hung, Yu-Sheng Hsiao. Biophysical Electrical and Mechanical Stimulations for Promoting Chondrogenesis of Stem Cells on PEDOT:PSS Conductive Polymer Scaffolds. Biomacromolecules 2023, 24 (8) , 3858-3871. https://doi.org/10.1021/acs.biomac.3c00506

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