ACS Publications. Most Trusted. Most Cited. Most Read

OR SEARCH CITATIONS

My Activity
Publications
CONTENT TYPES

Figure 1Loading Img
Download Hi-Res ImageDownload to MS-PowerPointCite This:ACS Biomater. Sci. Eng. 2016, 2, 9, 1442-1449
RETURN TO ISSUEPREVArticleNEXT

Porous Bioactive Nanofibers via Cryogenic Solution Blow Spinning and Their Formation into 3D Macroporous Scaffolds

View Author Information
† Materials and Biosystems Laboratory (LAMAB), Department of Materials Engineering (DEMat), Federal University of Paraíba (UFPB), CEP58051-900 João Pessoa-PB, Brazil
‡ Polymer and Composite Engineering (PaCE) Group, Institute of Materials Chemistry and Research, Faculty of Chemistry, University of Vienna, Währingerstr. 42, A-1090 Vienna, Austria
§ Institute of Biomaterials, Department of Materials Science and Engineering, University of Erlangen-Nuremberg, 91058 Erlangen, Germany
∥ Department of Mining and Materials Engineering, McGill University, Montreal, Quebec H3A 0E8, Canada
⊥ Bio-/Active Materials Group, School of Materials, MSS Tower, Manchester University, Manchester M13 9PL, U.K.
*E-mail: [email protected]
*E-mail: [email protected]
Cite this: ACS Biomater. Sci. Eng. 2016, 2, 9, 1442–1449
Publication Date (Web):July 19, 2016
https://doi.org/10.1021/acsbiomaterials.6b00072
Copyright © 2016 American Chemical Society
Request reuse permissions

    Article Views

    1515

    Altmetric

    -

    Citations

    45
    LEARN ABOUT THESE METRICS
    Read OnlinePDF (2 MB)
    Get e-Alerts
    Supporting Info (1)»
    SUBJECTS:

    Abstract

    Abstract Image

    There is increasing focus on the development of bioactive scaffolds for tissue engineering and regenerative medicine that mimic the native nanofibrillar extracellular matrix. Solution blow spinning (SBS) is a rapid, simple technique that produces nanofibers with open fiber networks for enhanced cell infiltration. In this work, highly porous bioactive fibers were produced by combining SBS with thermally induced phase separation. Fibers composed of poly(d,l-lactide) (PLA) and dimethyl carbonate were sprayed directly into a cryogenic environment and subsequently lyophilized, rendering them highly porous. The surface areas of the porous fibers were an order of magnitude higher in comparison with smooth control fibers of the same diameter (43.5 m2·g–1 for porous fibers produced from 15% w/v PLA in dimethyl carbonate) and exhibited elongated surface pores. Macroporous scaffolds were produced by spraying water droplets simultaneously with fiber formation, creating a network of fibers and ice microspheres, which act as in situ macroporosifiers. Subsequent lyophilization resulted in three-dimensional (3D) scaffolds formed of porous nanofibers with interconnected macropores due to the presence of the ice spheres. Nanobioactive glass was incorporated for the production of 3D macroporous, bioactive, therapeutic-ion-releasing scaffolds with potential applications in non-load-bearing bone tissue engineering. The bioactive characteristics of the fibers were assessed in vitro through immersion in simulated body fluid. The release of soluble silica ions was faster for the porous fibers within the first 24 h, with confirmation of hydroxyapatite on the fiber surface within 84 h.

    KEYWORDS:

    Supporting Information

    ARTICLE SECTIONS
    Jump To

    The Supporting Information is available free of charge on the ACS Publications website at DOI: 10.1021/acsbiomaterials.6b00072.

    • Further experimental details for TGA and determination of macroporosity due to ice microspheres; additional SEM images of porous fibers and spheres produced from 15, 10, and 4% w/v solutions of PDLLA in DMC (Figure S1); results of apparent contact angle measurements on smooth and porous fibers as a function of starting polymer concentration (Figure S2); TGA results to confirm loading nBG particles (Figure S3); histograms showing macropore diameters as a function of water flux and SBS air pressure (Figure S4); SEM image showing HA deposition on 10nBG fibers after 3.5 days in SBF (Figure S5); SEM images showing typical HA morphology on the 10nBG fibers after 7.5 days in SBF at low and medium magnification (Figure S6); XRD data showing predominantly HA on this scaffold after 7.5 days in SBF (Figure S7) (PDF)

    Terms & Conditions

    Most electronic Supporting Information files are available without a subscription to ACS Web Editions. Such files may be downloaded by article for research use (if there is a public use license linked to the relevant article, that license may permit other uses). Permission may be obtained from ACS for other uses through requests via the RightsLink permission system: http://pubs.acs.org/page/copyright/permissions.html.

    Cited By

    This article is cited by 45 publications.

    1. Lanjie Lei, Qizhuang Lv, Yan Jin, Hong An, Zhe Shi, Ge Hu, Yuze Yang, Xiangguo Wang, Lei Yang. Angiogenic Microspheres for the Treatment of a Thin Endometrium. ACS Biomaterials Science & Engineering 2021, 7 (10) , 4914-4920. https://doi.org/10.1021/acsbiomaterials.1c00615
    2. Chao Jia, Lei Li, Jianan Song, Ziwei Li, Hui Wu. Mass Production of Ultrafine Fibers by a Versatile Solution Blow Spinning Method. Accounts of Materials Research 2021, 2 (6) , 432-446. https://doi.org/10.1021/accountsmr.1c00040
    3. Seunghun S. Lee, Matthias Santschi, Stephen J. Ferguson. A Biomimetic Macroporous Hybrid Scaffold with Sustained Drug Delivery for Enhanced Bone Regeneration. Biomacromolecules 2021, 22 (6) , 2460-2471. https://doi.org/10.1021/acs.biomac.1c00241
    4. Danilo M. dos Santos, Daniel S. Correa, Eliton S. Medeiros, Juliano E. Oliveira, Luiz H. C. Mattoso. Advances in Functional Polymer Nanofibers: From Spinning Fabrication Techniques to Recent Biomedical Applications. ACS Applied Materials & Interfaces 2020, 12 (41) , 45673-45701. https://doi.org/10.1021/acsami.0c12410
    5. Jianan Song, Ziwei Li, Hui Wu. Blowspinning: A New Choice for Nanofibers. ACS Applied Materials & Interfaces 2020, 12 (30) , 33447-33464. https://doi.org/10.1021/acsami.0c05740
    6. Xueyong Yong, Qisong Hu, Ergang Zhou, Jianping Deng, Youping Wu. Polylactide-Based Chiral Porous Monolithic Materials Prepared Using the High Internal Phase Emulsion Template Method for Enantioselective Release. ACS Biomaterials Science & Engineering 2019, 5 (10) , 5072-5081. https://doi.org/10.1021/acsbiomaterials.9b01276
    7. Adrián Magaz, Aled D. Roberts, Sheida Faraji, Tatiana R. L. Nascimento, Eliton S. Medeiros, Wenzhao Zhang, Ryan D. Greenhalgh, Andreas Mautner, Xu Li, Jonny J. Blaker. Porous, Aligned, and Biomimetic Fibers of Regenerated Silk Fibroin Produced by Solution Blow Spinning. Biomacromolecules 2018, 19 (12) , 4542-4553. https://doi.org/10.1021/acs.biomac.8b01233
    8. Jing Li, Kaiju Luo, Junrong Yu, Yan Wang, Jing Zhu, Zuming Hu. Promising Free-Standing Polyimide Membrane via Solution Blow Spinning for High Performance Lithium-Ion Batteries. Industrial & Engineering Chemistry Research 2018, 57 (36) , 12296-12305. https://doi.org/10.1021/acs.iecr.8b02755
    9. Xinxin Miao, Hang Liao, Zhongbo Deng, Chen Li, Tianlong Wu, Huiqing Zhang, Miaoxing Liu, Xigao Cheng, and Xiaolei Wang . “Dandelion” Inspired Dual-Layered Nanoarrays with Two Model Releasing Features for the Surface Modification of 3D Printing Implants. ACS Biomaterials Science & Engineering 2017, 3 (10) , 2259-2266. https://doi.org/10.1021/acsbiomaterials.7b00456
    10. John L. Daristotle, Adam M. Behrens, Anthony D. Sandler, and Peter Kofinas . A Review of the Fundamental Principles and Applications of Solution Blow Spinning. ACS Applied Materials & Interfaces 2016, 8 (51) , 34951-34963. https://doi.org/10.1021/acsami.6b12994
    11. Meng Xia, Shuyu Ji, Yijun Fu, Jiamu Dai, Junxiong Zhang, Xiaomin Ma, Rong Liu. Alumina Ceramic Nanofibers: An Overview of the Spinning Gel Preparation, Manufacturing Process, and Application. Gels 2023, 9 (8) , 599. https://doi.org/10.3390/gels9080599
    12. Md. Kaiser Haider, Davood Kharaghani, Yuji Yoshiko, Ick Soo Kim. Lignin-facilitated growth of Ag/CuNPs on surface-activated polyacryloamidoxime nanofibers for superior antibacterial activity with improved biocompatibility. International Journal of Biological Macromolecules 2023, 242 , 124945. https://doi.org/10.1016/j.ijbiomac.2023.124945
    13. Haleema Saleem, Asif Saud, Nazmin Munira, Pei Sean Goh, Ahmad Fauzi Ismail, Hammadur Rahman Siddiqui, Syed Javaid Zaidi. Improved Forward Osmosis Performance of Thin Film Composite Membranes with Graphene Quantum Dots Derived from Eucalyptus Tree Leaves. Nanomaterials 2022, 12 (19) , 3519. https://doi.org/10.3390/nano12193519
    14. Lakshmipathy Muthukrishnan. An overview on electrospinning and its advancement toward hard and soft tissue engineering applications. Colloid and Polymer Science 2022, 300 (8) , 875-901. https://doi.org/10.1007/s00396-022-04997-9
    15. Kanchan Maji, Krishna Pramanik. Electrospun scaffold for bone regeneration. International Journal of Polymeric Materials and Polymeric Biomaterials 2022, 71 (11) , 842-857. https://doi.org/10.1080/00914037.2021.1915784
    16. Weiheng Xu, Sayli Jambhulkar, Dharneedar Ravichandran, Yuxiang Zhu, Shantanu Lanke, Mohammed Bawareth, Kenan Song. A mini‐review of microstructural control during composite fiber spinning. Polymer International 2022, 71 (5) , 569-577. https://doi.org/10.1002/pi.6350
    17. Erik W. Dorthé, Austin B. Williams, Shawn P. Grogan, Darryl D. D’Lima. Pneumatospinning Biomimetic Scaffolds for Meniscus Tissue Engineering. Frontiers in Bioengineering and Biotechnology 2022, 10 https://doi.org/10.3389/fbioe.2022.810705
    18. Ali Maghsoudian, Samira Alvani, Roxana Moaref, Seifollah Jamalpour, Yousef Tamsilian, Alireza Kiasat. The concept of biomimetics in the development of protective textiles. 2022, 133-173. https://doi.org/10.1016/B978-0-323-90477-3.00022-5
    19. E. S. Trofimchuk, V. V. Potseleev, M. A. Khavpachev, M. A. Moskvina, N. I. Nikonorova. Polylactide-Based Porous Materials: Synthesis, Hydrolytic Degradation Features, and Application Areas. Polymer Science, Series C 2021, 63 (2) , 199-218. https://doi.org/10.1134/S1811238221020107
    20. D. Torres Ulloa, J. J. Blaker. Soft Fibrillar Biomaterials by Fibre Spinning Routes. 2021, 425-443. https://doi.org/10.1039/9781839161124-00425
    21. Caio V. L. Natarelli, Caio M. S. Lopes, Jefferson S. S. Carneiro, Leônidas C. A. Melo, Juliano E. Oliveira, Eliton S. Medeiros. Zinc slow-release systems for maize using biodegradable PBAT nanofibers obtained by solution blow spinning. Journal of Materials Science 2021, 56 (7) , 4896-4908. https://doi.org/10.1007/s10853-020-05545-y
    22. Eudes L.G. Medeiros, Déborah S. Gomes, Adillys M.C. Santos, Rafaela H. Vieira, Isabela L. de Lima, Flaviana S. Rocha, Leticia de S. Castro-Filice, Eliton S. Medeiros, Gelmires A. Neves, Romualdo R. Menezes. 3D nanofibrous bioactive glass scaffolds produced by one-step spinning process. Ceramics International 2021, 47 (1) , 102-110. https://doi.org/10.1016/j.ceramint.2020.08.112
    23. Tamara Holjevac Grgurić, Budimir Mijović, Emilija Zdraveva, Emi Govorčin Bajsić, Igor Slivac, Massimo Ujčić, Iva Dekaris, Mirna Tominac Trcin, Anamarija Vuković, Sunčica Kuzmić, Andrea Ledić, Maja Jelena Čop, Marijan Logarušić. Electrospinning of PCL/CEFUROXIM® fibrous scaffolds on 3D printed collectors. The Journal of The Textile Institute 2020, 111 (9) , 1288-1299. https://doi.org/10.1080/00405000.2019.1707347
    24. Fernanda Trindade Gonzalez Dias, Silvana Pereira Rempel, Lucas Dall Agnol, Otávio Bianchi. The main blow spun polymer systems: processing conditions and applications. Journal of Polymer Research 2020, 27 (8) https://doi.org/10.1007/s10965-020-02173-7
    25. Rasheed Atif, Jibran Khaliq, Madeleine Combrinck, Ahmed H. Hassanin, Nader Shehata, Eman Elnabawy, Islam Shyha. Solution Blow Spinning of Polyvinylidene Fluoride Based Fibers for Energy Harvesting Applications: A Review. Polymers 2020, 12 (6) , 1304. https://doi.org/10.3390/polym12061304
    26. Seungho Baek, Heekyung Park, Minseok Kim, Donghyun Lee. Preparation of PCL/(+)-catechin/gelatin film for wound healing using air-jet spinning. Applied Surface Science 2020, 509 , 145033. https://doi.org/10.1016/j.apsusc.2019.145033
    27. Tingting Zhang, Hua Tian, Xueqiong Yin, Zhiming Li, Xiaohui Zhang, Jianxin Yang, Li Zhu. Solution Blow Spinning of Polylactic Acid to Prepare Fibrous Oil Adsorbents Through Morphology Optimization with Response Surface Methodology. Journal of Polymers and the Environment 2020, 28 (3) , 812-825. https://doi.org/10.1007/s10924-019-01617-6
    28. Aled D. Roberts, Jet-Sing M. Lee, Adrián Magaz, Martin W. Smith, Michael Dennis, Nigel S. Scrutton, Jonny J. Blaker. Hierarchically Porous Silk/Activated-Carbon Composite Fibres for Adsorption and Repellence of Volatile Organic Compounds. Molecules 2020, 25 (5) , 1207. https://doi.org/10.3390/molecules25051207
    29. Tatiana Rita de Lima Nascimento, Marilia Mattar de Amoêdo Campos Velo, Camila Félix Silva, Sara Brito Silva Costa Cruz, Brenna Louise Cavalcanti Gondim, Rafael Francisco Lia Mondelli, Lúcio Roberto Cançado Castellano. Current Applications of Biopolymer-based Scaffolds and Nanofibers as Drug Delivery Systems. Current Pharmaceutical Design 2019, 25 (37) , 3997-4012. https://doi.org/10.2174/1381612825666191108162948
    30. Jiaping Zhang, Hideki Kitayama, Yasuo Gotoh, Antje Potthast, Thomas Rosenau. Non-woven fabrics of fine regenerated cellulose fibers prepared from ionic-liquid solution via wet type solution blow spinning. Carbohydrate Polymers 2019, 226 , 115258. https://doi.org/10.1016/j.carbpol.2019.115258
    31. Tamara L. Akentjew, Claudia Terraza, Cristian Suazo, Jekaterina Maksimcuka, Camila A. Wilkens, Francisco Vargas, Gabriela Zavala, Macarena Ocaña, Javier Enrione, Claudio M. García-Herrera, Loreto M. Valenzuela, Jonny J. Blaker, Maroun Khoury, Juan Pablo Acevedo. Rapid fabrication of reinforced and cell-laden vascular grafts structurally inspired by human coronary arteries. Nature Communications 2019, 10 (1) https://doi.org/10.1038/s41467-019-11090-3
    32. Marilia M.A.C. Velo, Tatiana R.L. Nascimento, Cassiana K. Scotti, Juliana F.S. Bombonatti, Adilson Y. Furuse, Vinícius D. Silva, Thiago A. Simões, Eliton S. Medeiros, Jonny J. Blaker, Nikolaos Silikas, Rafael F.L. Mondelli. Improved mechanical performance of self-adhesive resin cement filled with hybrid nanofibers-embedded with niobium pentoxide. Dental Materials 2019, 35 (11) , e272-e285. https://doi.org/10.1016/j.dental.2019.08.102
    33. Eliraldrin Amorin Sousa, Michael Jones Silva, Alex Otávio Sanches, Viviane Oliveira Soares, Aldo Eloizo Job, José Antonio Malmonge. Mechanical, thermal, and morphological properties of natural rubber/45S5 Bioglass® fibrous mat with ribbon-like morphology produced by solution blow spinning. European Polymer Journal 2019, 119 , 1-7. https://doi.org/10.1016/j.eurpolymj.2019.07.002
    34. Ya Huang, Jianan Song, Cheng Yang, Yuanzheng Long, Hui Wu. Scalable manufacturing and applications of nanofibers. Materials Today 2019, 28 , 98-113. https://doi.org/10.1016/j.mattod.2019.04.018
    35. Cang Wang, Min Pan, Hang Chen, Dajing Chen, Yuquan Chen. The Novel biocatalytic cascade ZIF-8 capsule/Polysulfone Stereostructure and its Application in Amperometric Glucose Biosensors. International Journal of Electrochemical Science 2019, 14 (9) , 8836-8851. https://doi.org/10.20964/2019.09.13
    36. Cang Wang, Min Pan, Hang Chen, Dajing Chen, Yuquan Chen. Novel Glucose Oxidase Interlocked Prussian Blue/Polysulfone Stereo-Structure and its Application in Amperometric Glucose Biosensor. International Journal of Electrochemical Science 2019, 14 (8) , 8014-8027. https://doi.org/10.20964/2019.08.51
    37. Biranche Tandon, Prashant Kamble, Richard Olsson, Jonny Blaker, Sarah Cartmell. Fabrication and Characterisation of Stimuli Responsive Piezoelectric PVDF and Hydroxyapatite-Filled PVDF Fibrous Membranes. Molecules 2019, 24 (10) , 1903. https://doi.org/10.3390/molecules24101903
    38. Aula Alwattar, Athir Haddad, Quan Zhou, Tatiana Nascimento, Ryan Greenhalgh, Eliton Medeiros, Jonny Blaker, Adam Parry, Peter Quayle, Stephen Yeates. Synthesis and characterisation of fluorescent pyrene‐end‐capped polylactide fibres. Polymer International 2019, 68 (3) , 360-368. https://doi.org/10.1002/pi.5712
    39. Ju Lv, Xueqiong Yin, Rongguo Li, Junhua Chen, Qiang Lin, Li Zhu. Superhydrophobic PCL/PS composite nanofibrous membranes prepared through solution blow spinning with an airbrush for oil adsorption. Polymer Engineering & Science 2019, 59 (S1) https://doi.org/10.1002/pen.24898
    40. Chunli Hou, Xiang Zhang, Yifan Li, Guoli Zhou, Jingtao Wang. Porous nanofibrous composite membrane for unparalleled proton conduction. Journal of Membrane Science 2018, 550 , 136-144. https://doi.org/10.1016/j.memsci.2017.12.067
    41. Indong Jun, Hyung-Seop Han, James Edwards, Hojeong Jeon. Electrospun Fibrous Scaffolds for Tissue Engineering: Viewpoints on Architecture and Fabrication. International Journal of Molecular Sciences 2018, 19 (3) , 745. https://doi.org/10.3390/ijms19030745
    42. Jing Li, Guocheng Song, Junrong Yu, Yan Wang, Jing Zhu, Zuming Hu. Preparation of Solution Blown Polyamic Acid Nanofibers and Their Imidization into Polyimide Nanofiber Mats. Nanomaterials 2017, 7 (11) , 395. https://doi.org/10.3390/nano7110395
    43. Ryan D. Greenhalgh, William S. Ambler, Stephen J. Quinn, Eliton S. Medeiros, Michael Anderson, Barbara Gore, Angelika Menner, Alexander Bismarck, Xu Li, Nicola Tirelli, Jonny J. Blaker. Hybrid sol–gel inorganic/gelatin porous fibres via solution blow spinning. Journal of Materials Science 2017, 52 (15) , 9066-9081. https://doi.org/10.1007/s10853-017-0868-1
    44. Ana Letícia Braz, Ifty Ahmed, . Manufacturing processes for polymeric micro and nanoparticles and their biomedical applications. AIMS Bioengineering 2017, 4 (1) , 46-72. https://doi.org/10.3934/bioeng.2017.1.46
    45. Elena Stojanovska, Emine Canbay, Esra Serife Pampal, Mehmet D. Calisir, Onur Agma, Yusuf Polat, Ramazan Simsek, N. A. Serhat Gundogdu, Yasin Akgul, Ali Kilic. A review on non-electro nanofibre spinning techniques. RSC Advances 2016, 6 (87) , 83783-83801. https://doi.org/10.1039/C6RA16986D
    Download PDF

    Pair your accounts.

    Export articles to Mendeley

    Get article recommendations from ACS based on references in your Mendeley library.

    Pair your accounts.

    Export articles to Mendeley

    Get article recommendations from ACS based on references in your Mendeley library.

    You’ve supercharged your research process with ACS and Mendeley!

    STEP 1:
    Click to create an ACS ID

    Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

    Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

    Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

    MENDELEY PAIRING EXPIRED
    Your Mendeley pairing has expired. Please reconnect