ACS Publications. Most Trusted. Most Cited. Most Read

OR SEARCH CITATIONS

My Activity
Publications
CONTENT TYPES

Figure 1Loading Img
Download Hi-Res ImageDownload to MS-PowerPointCite This:ACS Biomater. Sci. Eng. 2016, 2, 12, 2240-2254
RETURN TO ISSUEPREVArticleNEXT

Designing Porous Bone Tissue Engineering Scaffolds with Enhanced Mechanical Properties from Composite Hydrogels Composed of Modified Alginate, Gelatin, and Bioactive Glass

View Author Information
Institute of Biomaterials, Department of Materials Science and Engineering, University of Erlangen-Nuremberg, Cauerstrasse 6, 91058 Erlangen, Germany
*E-mail: [email protected]
Cite this: ACS Biomater. Sci. Eng. 2016, 2, 12, 2240–2254
Publication Date (Web):October 3, 2016
https://doi.org/10.1021/acsbiomaterials.6b00470
Copyright © 2016 American Chemical Society
Request reuse permissions

    Article Views

    2741

    Altmetric

    -

    Citations

    95
    LEARN ABOUT THESE METRICS
    Read OnlinePDF (3 MB)
    Get e-Alerts
    Supporting Info (1)»
    SUBJECTS:

    Abstract

    Abstract Image

    The combination of biodegradable polymers and bioactive inorganic materials is being widely used for designing bone tissue engineering scaffolds. Here we report a composite hydrogel system composed of bioactive glass incorporated in covalently cross-linked oxidized alginate-gelatin hydrogel (ADA-GEL) for designing porous scaffolds with tunable stiffness and degradability using freeze-drying technique. Because of the presence of bioactive glass, the cross-linking kinetic and cross-linking degree of the hydrogels are significantly increased, which is the main factor for the measured enhanced mechanical strength of the bioactive glass containing ADA-GEL scaffolds. The hydrogels with high cross-linking degree exhibit low protein release profile and low degradability. Apatite formation on bioactive glass containing hydrogel-based scaffolds is confirmed by FTIR. Bone marrow-derived stromal cell growth is promoted in pristine ADA-GEL and 1% bioactive glass containing ADA-GEL scaffolds compared to the scaffolds of pure alginate, alginate–gelatin blended hydrogel, and 5% bioactive glass containing ADA-GEL. Initial studies indicated that the scaffolds, especially without bioactive glass, support osteogenic differentiation of murine bone marrow stromal cell line in the absence of foreign osteogenic stimulating supplements; however, they exhibit low levels of osteogenic expression.

    KEYWORDS:

    Supporting Information

    ARTICLE SECTIONS
    Jump To

    The Supporting Information is available free of charge on the ACS Publications website at DOI: 10.1021/acsbiomaterials.6b00470.

    • Compressive stress–strain curves of the as-fabricated scaffolds and after 28 days of incubation in SBF; SEM images of the ADA-GEL-5BG scaffolds after various incubation periods in SBF; and SEM images of ST-2 cells grown on ADA-GEL-1BG scaffolds (PDF)

    Terms & Conditions

    Most electronic Supporting Information files are available without a subscription to ACS Web Editions. Such files may be downloaded by article for research use (if there is a public use license linked to the relevant article, that license may permit other uses). Permission may be obtained from ACS for other uses through requests via the RightsLink permission system: http://pubs.acs.org/page/copyright/permissions.html.

    Cited By

    This article is cited by 95 publications.

    1. Qinghua Hou, Kun Liu, Chenxi Lian, Jiawei Liu, Wenying Wei, Tong Qiu, Honglian Dai. A Gelatin-Based Composite Hydrogel with a “One Stone, Two Birds” Strategy for Photothermal Antibacterial and Vascularization of Infected Wounds. Biomacromolecules 2023, 24 (7) , 3397-3410. https://doi.org/10.1021/acs.biomac.3c00471
    2. Jugal Kishore Sahoo, Dawei Xu, Thomas Falcucci, Jaewon Choi, Onur Hasturk, Douglas S. Clark, David L. Kaplan. Horseradish Peroxidase Catalyzed Silk–Prefoldin Composite Hydrogel Networks. ACS Applied Bio Materials 2023, 6 (1) , 203-208. https://doi.org/10.1021/acsabm.2c00836
    3. Kaixuan Teng, Qi An, Yao Chen, Yihe Zhang, Yantao Zhao. Recent Development of Alginate-Based Materials and Their Versatile Functions in Biomedicine, Flexible Electronics, and Environmental Uses. ACS Biomaterials Science & Engineering 2021, 7 (4) , 1302-1337. https://doi.org/10.1021/acsbiomaterials.1c00116
    4. Thomas Distler, Kilian McDonald, Susanne Heid, Emine Karakaya, Rainer Detsch, Aldo R. Boccaccini. Ionically and Enzymatically Dual Cross-Linked Oxidized Alginate Gelatin Hydrogels with Tunable Stiffness and Degradation Behavior for Tissue Engineering. ACS Biomaterials Science & Engineering 2020, 6 (7) , 3899-3914. https://doi.org/10.1021/acsbiomaterials.0c00677
    5. Daniel Massana Roquero, Paolo Bollella, Artem Melman, Evgeny Katz. Nanozyme-Triggered DNA Release from Alginate Films. ACS Applied Bio Materials 2020, 3 (6) , 3741-3750. https://doi.org/10.1021/acsabm.0c00348
    6. Óscar L. Rodríguez-Montaño, Carlos Julio Cortés-Rodríguez, Francesco Naddeo, Antonio E. Uva, Michele Fiorentino, Alessandro Naddeo, Nicola Cappetti, Michele Gattullo, Giuseppe Monno, Antonio Boccaccio. Irregular Load Adapted Scaffold Optimization: A Computational Framework Based on Mechanobiological Criteria. ACS Biomaterials Science & Engineering 2019, 5 (10) , 5392-5411. https://doi.org/10.1021/acsbiomaterials.9b01023
    7. Mingjiao Chen, Yuanhao Zhang, Qing Xie, Weian Zhang, Xiuwei Pan, Ping Gu, Huifang Zhou, Yun Gao, Andreas Walther, Xianqun Fan. Long-Term Bone Regeneration Enabled by a Polyhedral Oligomeric Silsesquioxane (POSS)-Enhanced Biodegradable Hydrogel. ACS Biomaterials Science & Engineering 2019, 5 (9) , 4612-4623. https://doi.org/10.1021/acsbiomaterials.9b00642
    8. Alexandra M. Ward, Graeme R. A. Wyllie. Bioplastics in the General Chemistry Laboratory: Building a Semester-Long Research Experience. Journal of Chemical Education 2019, 96 (4) , 668-676. https://doi.org/10.1021/acs.jchemed.8b00666
    9. Lun Yuan, Xinying Li, Liming Ge, Xiaoqi Jia, Jinfeng Lei, Changdao Mu, Defu Li. Emulsion Template Method for the Fabrication of Gelatin-Based Scaffold with a Controllable Pore Structure. ACS Applied Materials & Interfaces 2019, 11 (1) , 269-277. https://doi.org/10.1021/acsami.8b17555
    10. Ting Li, Fanrong Ai, Wanji Shen, Yu Yang, Yan Zhou, Jianjian Deng, Chen Li, Xinwei Ding, Hongbo Xin, Xiaolei Wang. Microstructural Orientation and Precise Regeneration: A Proof-of-Concept Study on the Sugar-Cane-Derived Implants with Bone-Mimetic Hierarchical Structure. ACS Biomaterials Science & Engineering 2018, 4 (12) , 4331-4337. https://doi.org/10.1021/acsbiomaterials.8b01052
    11. Supachai Reakasame and Aldo R. Boccaccini . Oxidized Alginate-Based Hydrogels for Tissue Engineering Applications: A Review. Biomacromolecules 2018, 19 (1) , 3-21. https://doi.org/10.1021/acs.biomac.7b01331
    12. Xiangfeng Li, Menglu Wang, Yanglong Deng, Xuening Chen, Yumei Xiao, and Xingdong Zhang . Fabrication and Properties of Ca-P Bioceramic Spherical Granules with Interconnected Porous Structure. ACS Biomaterials Science & Engineering 2017, 3 (8) , 1557-1566. https://doi.org/10.1021/acsbiomaterials.7b00232
    13. Xinyun Zhai, Yufei Ma, Chunyong Hou, Fei Gao, Yinyu Zhang, Changshun Ruan, Haobo Pan, William Weijia Lu, and Wenguang Liu . 3D-Printed High Strength Bioactive Supramolecular Polymer/Clay Nanocomposite Hydrogel Scaffold for Bone Regeneration. ACS Biomaterials Science & Engineering 2017, 3 (6) , 1109-1118. https://doi.org/10.1021/acsbiomaterials.7b00224
    14. Ponnurengam Malliappan Sivakumar, Abuzer Alp Yetisgin, Ebru Demir, Sevilay Burcu Sahin, Sibel Cetinel. Polysaccharide-bioceramic composites for bone tissue engineering: A review. International Journal of Biological Macromolecules 2023, 250 , 126237. https://doi.org/10.1016/j.ijbiomac.2023.126237
    15. Yusheng Yang, Shenghui Su, Shencai Liu, Weilu Liu, Qinfeng Yang, Liangjie Tian, Zilin Tan, Lei Fan, Bin Yu, Jian Wang, Yanjun Hu. Triple-functional bone adhesive with enhanced internal fixation, bacteriostasis and osteoinductive properties for open fracture repair. Bioactive Materials 2023, 25 , 273-290. https://doi.org/10.1016/j.bioactmat.2023.01.021
    16. Abdullah Aldhaher, Fahimeh Shahabipour, Abdullah Shaito, Saphwan Al-Assaf, Ahmed A.M. Elnour, El Bashier Sallam, Shahin Teimourtash, Abdelgadir A. Elfadil. 3D hydrogel/ bioactive glass scaffolds in bone tissue engineering: Status and future opportunities. Heliyon 2023, 9 (7) , e17050. https://doi.org/10.1016/j.heliyon.2023.e17050
    17. D. Zhou, C. Wang, A. Hert, L. Yan, B. Dou, L. Ouyang. 3D Printing of Multicomponent Hydrogels for Biomedical Applications. 2023, 231-287. https://doi.org/10.1039/BK9781837670055-00231
    18. Geeta Kumari Wasupalli, Devendra Verma. Development of chitosan‐polygalacturonic acid polyelectrolyte complex fibrous scaffolds using the hydrothermal treatment for bone tissue engineering. Journal of Biomedical Materials Research Part A 2023, 111 (3) , 354-366. https://doi.org/10.1002/jbm.a.37461
    19. Jae-Won Jang, Kyung-Eun Min, Cheolhee Kim, Jesik Shin, Jiwoon Lee, Sung Yi. Review: Scaffold Characteristics, Fabrication Methods, and Biomaterials for the Bone Tissue Engineering. International Journal of Precision Engineering and Manufacturing 2023, 24 (3) , 511-529. https://doi.org/10.1007/s12541-022-00755-7
    20. Sathish K. Kurapati, N. Mahendar Reddy, R. Sujithra, Ramesh Kola, Gubbala V. Ramesh, D. Saritha. Nanomaterials and Nanostructures in Additive Manufacturing: Properties, Applications, and Technological Challenges. 2023, 53-102. https://doi.org/10.1002/9783527835478.ch3
    21. Azizeh Rahmani Del Bakhshayesh, Solmaz Saghebasl, Nahideh Asadi, Elmira Kashani, Ahmad Mehdipour, Amir Nezami Asl, Abolfazl Akbarzadeh. Recent advances in nano‐scaffolds for tissue engineering applications: Toward natural therapeutics. WIREs Nanomedicine and Nanobiotechnology 2023, 9 https://doi.org/10.1002/wnan.1882
    22. Jun Liu, Lili Yang, Kexin Liu, Feng Gao. Hydrogel scaffolds in bone regeneration: Their promising roles in angiogenesis. Frontiers in Pharmacology 2023, 14 https://doi.org/10.3389/fphar.2023.1050954
    23. Sugandha Gupta, Preeti Singh, Parul Verma, Malvika Chaudhary, Sajid Ali. Bisphosphonate-based nanocomposite hydrogels for biomedical applications. 2023, 541-557. https://doi.org/10.1016/B978-0-323-99638-9.00022-8
    24. Soledad Stagnoli, Cintia Garro, Ozlem Ertekin, Susanne Heid, Stefan Seyferth, Gastón Soria, N. Mariano Correa, Aldo Leal-Egaña, Aldo R. Boccaccini. Topical systems for the controlled release of antineoplastic Drugs: Oxidized Alginate-Gelatin Hydrogel/Unilamellar vesicles. Journal of Colloid and Interface Science 2023, 629 , 1066-1080. https://doi.org/10.1016/j.jcis.2022.08.163
    25. Maria E. V. Barreto, Rebeca P. Medeiros, Adam Shearer, Marcus V. L. Fook, Maziar Montazerian, John C. Mauro. Gelatin and Bioactive Glass Composites for Tissue Engineering: A Review. Journal of Functional Biomaterials 2023, 14 (1) , 23. https://doi.org/10.3390/jfb14010023
    26. Himanshu Taneja, Sandeep M. Salodkar, Avanish Singh Parmar, Shilpi Chaudhary. Hydrogel based 3D printing: Bio ink for tissue engineering. Journal of Molecular Liquids 2022, 367 , 120390. https://doi.org/10.1016/j.molliq.2022.120390
    27. D S Abdullah Al Maruf, Yohaann Ali Ghosh, Hai Xin, Kai Cheng, Payal Mukherjee, Jeremy Micah Crook, Gordon George Wallace, Travis Jacob Klein, Jonathan Robert Clark. Hydrogel: A Potential Material for Bone Tissue Engineering Repairing the Segmental Mandibular Defect. Polymers 2022, 14 (19) , 4186. https://doi.org/10.3390/polym14194186
    28. Mahshid Monavari, Rucha Medhekar, Qaisar Nawaz, Mehran Monavari, Miguel Fuentes‐Chandía, Shahin Homaeigohar, Aldo R. Boccaccini. A 3D Printed Bone Tissue Engineering Scaffold Composed of Alginate Dialdehyde‐Gelatine Reinforced by Lysozyme Loaded Cerium Doped Mesoporous Silica‐Calcia Nanoparticles. Macromolecular Bioscience 2022, 22 (9) https://doi.org/10.1002/mabi.202200113
    29. Farnaz Ghorbani, Minjoo Kim, Mahshid Monavari, Behafarid Ghalandari, Aldo R. Boccaccini. Mussel-inspired polydopamine decorated alginate dialdehyde-gelatin 3D printed scaffolds for bone tissue engineering application. Frontiers in Bioengineering and Biotechnology 2022, 10 https://doi.org/10.3389/fbioe.2022.940070
    30. Marija M. Babić Radić, Vuk V. Filipović, Jovana S. Vuković, Marija Vukomanović, Marina Rubert, Sandra Hofmann, Ralph Müller, Simonida Lj. Tomić. Bioactive Interpenetrating Hydrogel Networks Based on 2-Hydroxyethyl Methacrylate and Gelatin Intertwined with Alginate and Dopped with Apatite as Scaffolding Biomaterials. Polymers 2022, 14 (15) , 3112. https://doi.org/10.3390/polym14153112
    31. M. S. Kairon Mubina, S. Shailajha, R. Sankaranarayanan, M. Iyyadurai. Bone formation with high bacterial inhibition and low toxicity behavior by melding of Al2O3 on nanobioactive glass ceramics via sol-gel process. Journal of Sol-Gel Science and Technology 2022, 103 (1) , 151-171. https://doi.org/10.1007/s10971-022-05842-9
    32. Fatemeh Mohabatpour, Zahra Yazdanpanah, Silvana Papagerakis, Xiongbiao Chen, Petros Papagerakis. Self-Crosslinkable Oxidized Alginate-Carboxymethyl Chitosan Hydrogels as an Injectable Cell Carrier for In Vitro Dental Enamel Regeneration. Journal of Functional Biomaterials 2022, 13 (2) , 71. https://doi.org/10.3390/jfb13020071
    33. Yusheng Cheng, Yihang Gong, Xiuxing Chen, Qi Zhang, Xijian Zhang, Yizhan He, Lijie Pan, Beibei Ni, Fan Yang, Yan Xu, Lei Zhou, Yang Yang, Wenjie Chen. Injectable adhesive hemostatic gel with tumor acidity neutralizer and neutrophil extracellular traps lyase for enhancing adoptive NK cell therapy prevents post-resection recurrence of hepatocellular carcinoma. Biomaterials 2022, 284 , 121506. https://doi.org/10.1016/j.biomaterials.2022.121506
    34. Sonja Kuth, Liliana Liverani. Biodegradable and bioactive polymer/inorganic phase composites. 2022, 179-212. https://doi.org/10.1016/B978-0-12-820508-2.00012-X
    35. Muhammad Umar Aslam Khan, Mohsin Ali Raza, Sajjad Haider, Saqlain A. Shah, Muhammad Arshed, Saiful Izwan Abd Razak, Adnan Haider. Medical applications of polymer/functionalized nanoparticle composite systems, renewable polymers, and polymer–metal oxide composites. 2022, 129-164. https://doi.org/10.1016/B978-0-323-85155-8.00006-6
    36. S.I. Magagula, M. Mohapi, N. Jafta, M.J. Mochane, K. Lebelo, G.G. Lenetha. Biopolymer-based biodegradable biomaterials for in vivo and in vitro biomedical applications. 2022, 165-210. https://doi.org/10.1016/B978-0-323-85233-3.00005-7
    37. Nguyen Thi Thanh Uyen, Syazana Ahmad Zubir, Tuti Katrina Abdullah, Nurazreena Ahmad. Alginate microspheres: Synthesis and their biomedical applications. 2022, 255-283. https://doi.org/10.1016/B978-0-323-90986-0.00004-2
    38. Xinxin Ding, Junyu Shi, Jianxu Wei, Yuan Li, Xiangbing Wu, Yi Zhang, Xue Jiang, Xiaomeng Zhang, Hongchang Lai. A biopolymer hydrogel electrostatically reinforced by amino-functionalized bioactive glass for accelerated bone regeneration. Science Advances 2021, 7 (50) https://doi.org/10.1126/sciadv.abj7857
    39. Ehsan Zeimaran, Sara Pourshahrestani, Ali Fathi, Nasrul Anuar bin Abd Razak, Nahrizul Adib Kadri, Amir Sheikhi, Francesco Baino. Advances in bioactive glass-containing injectable hydrogel biomaterials for tissue regeneration. Acta Biomaterialia 2021, 136 , 1-36. https://doi.org/10.1016/j.actbio.2021.09.034
    40. Lanlan Wang, Dawei Li, Ying Shen, Feng Liu, Yuqi Zhou, Huiping Wu, Qingsheng Liu, Bingyao Deng. Preparation of Centella asiatica loaded gelatin/chitosan/nonwoven fabric composite hydrogel wound dressing with antibacterial property. International Journal of Biological Macromolecules 2021, 192 , 350-359. https://doi.org/10.1016/j.ijbiomac.2021.09.145
    41. Mahshid Monavari, Shahin Homaeigohar, Miguel Fuentes-Chandía, Qaisar Nawaz, Mehran Monavari, Arvind Venkatraman, Aldo R. Boccaccini. 3D printing of alginate dialdehyde-gelatin (ADA-GEL) hydrogels incorporating phytotherapeutic icariin loaded mesoporous SiO2-CaO nanoparticles for bone tissue engineering. Materials Science and Engineering: C 2021, 131 , 112470. https://doi.org/10.1016/j.msec.2021.112470
    42. Alda Malagón-Escandón, Mathieu Hautefeuille, Edgar Jimenez-Díaz, Jesus Arenas-Alatorre, José Manuel Saniger, Isidro Badillo-Ramírez, Nadia Vazquez, Gabriela Piñón-Zarate, Andrés Castell-Rodríguez. Three-Dimensional Porous Scaffolds Derived from Bovine Cancellous Bone Matrix Promote Osteoinduction, Osteoconduction, and Osteogenesis. Polymers 2021, 13 (24) , 4390. https://doi.org/10.3390/polym13244390
    43. Cheng-Hsin Cheng, Ming-You Shie, Yi-Hui Lai, Ning-Ping Foo, Mon-Juan Lee, Chun-Hsu Yao. Fabrication of 3D Printed Poly(lactic acid)/Polycaprolactone Scaffolds Using TGF-β1 for Promoting Bone Regeneration. Polymers 2021, 13 (21) , 3731. https://doi.org/10.3390/polym13213731
    44. Hang Zhang, Yinze Xiong, Lanlan Dong, Yifan Shen, Hongxing Hu, Hong Gao, Shichang Zhao, Xiang Li. Microstructural, mechanical properties and strengthening mechanism of DLP produced β-tricalcium phosphate scaffolds by incorporation of MgO/ZnO/58S bioglass. Ceramics International 2021, 47 (18) , 25863-25874. https://doi.org/10.1016/j.ceramint.2021.05.317
    45. Supachai Reakasame, Dalia Dranseikiene, Stefan Schrüfer, Kai Zheng, Dirk W. Schubert, Aldo R. Boccaccini. Development of alginate dialdehyde-gelatin based bioink with methylcellulose for improving printability. Materials Science and Engineering: C 2021, 128 , 112336. https://doi.org/10.1016/j.msec.2021.112336
    46. Fei‐Fan Cai, Susanne Heid, Aldo R. Boccaccini. Potential of Laponite® incorporated oxidized alginate–gelatin ( ADA‐GEL ) composite hydrogels for extrusion‐based 3D printing. Journal of Biomedical Materials Research Part B: Applied Biomaterials 2021, 109 (8) , 1090-1104. https://doi.org/10.1002/jbm.b.34771
    47. Katharina Schuhladen, Usanee Pantulap, Kristin Engel, Piotr Jeleń, Zbigniew Olejniczak, Leena Hupa, Maciej Sitarz, Aldo R. Boccaccini. Influence of the replacement of silica by boron trioxide on the properties of bioactive glass scaffolds. International Journal of Applied Glass Science 2021, 12 (3) , 293-312. https://doi.org/10.1111/ijag.15894
    48. Ali Can Özarslan, Yeliz Basaran Elalmis, Sevil Yücel. Production of biosilica based bioactive glass-alginate composite putty as bone support material, and evaluation of in vitro properties; bioactivity and cytotoxicity behavior. Journal of Non-Crystalline Solids 2021, 561 , 120755. https://doi.org/10.1016/j.jnoncrysol.2021.120755
    49. Tai-Yu Chen, Shih-Fu Ou, Hsiu-Wen Chien. Biomimetic Mineralization of Tannic Acid-Supplemented HEMA/SBMA Nanocomposite Hydrogels. Polymers 2021, 13 (11) , 1697. https://doi.org/10.3390/polym13111697
    50. Carlos Rhamon do N. Ferreira, Everton Lucas de L. Ramos, Luis Felipe S. Araujo, Leonira Morais da S. Sousa, Judith Pessoa A. Feitosa, Ana Filipa Cunha, Mariana B. Oliveira, João F. Mano, Jeanny da S. Maciel. Synthesis and characterization of scaffolds produced under mild conditions based on oxidized cashew gums and carboxyethyl chitosan. International Journal of Biological Macromolecules 2021, 176 , 26-36. https://doi.org/10.1016/j.ijbiomac.2021.01.178
    51. Sara Liparoti, Vito Speranza, Francesco Marra. Alginate hydrogel: The influence of the hardening on the rheological behaviour. Journal of the Mechanical Behavior of Biomedical Materials 2021, 116 , 104341. https://doi.org/10.1016/j.jmbbm.2021.104341
    52. Xiaoli Kong, Long Chen, Bo Li, Changyun Quan, Jun Wu. Applications of oxidized alginate in regenerative medicine. Journal of Materials Chemistry B 2021, 9 (12) , 2785-2801. https://doi.org/10.1039/D0TB02691C
    53. M. Sai Bhargava Reddy, Deepalekshmi Ponnamma, Rajan Choudhary, Kishor Kumar Sadasivuni. A Comparative Review of Natural and Synthetic Biopolymer Composite Scaffolds. Polymers 2021, 13 (7) , 1105. https://doi.org/10.3390/polym13071105
    54. Lei Zhou, Lei Fan, Feng-Miao Zhang, Yuhe Jiang, Min Cai, Cong Dai, Yi-An Luo, Ling-Jie Tu, Zheng-Nan Zhou, Xiao-Jun Li, Cheng-Yun Ning, Kai Zheng, Aldo R. Boccaccini, Guo-Xin Tan. Hybrid gelatin/oxidized chondroitin sulfate hydrogels incorporating bioactive glass nanoparticles with enhanced mechanical properties, mineralization, and osteogenic differentiation. Bioactive Materials 2021, 6 (3) , 890-904. https://doi.org/10.1016/j.bioactmat.2020.09.012
    55. Ammara Sathain, Pathavuth Monvisade, Punnama Siriphannon. Bioactive alginate/carrageenan/calcium silicate porous scaffolds for bone tissue engineering. Materials Today Communications 2021, 26 , 102165. https://doi.org/10.1016/j.mtcomm.2021.102165
    56. Chasuda Choipang, Tanawat Buntum, Piyachat Chuysinuan, Supanna Techasakul, Pitt Supaphol, Orawan Suwantong. Gelatin scaffolds loaded with asiaticoside/ 2‐hydroxypropyl‐β ‐cyclodextrin complex for use as wound dressings. Polymers for Advanced Technologies 2021, 32 (3) , 1187-1193. https://doi.org/10.1002/pat.5166
    57. Ahmad Reza Farmani, Mohammad Hossein Nekoofar, Somayeh Ebrahimi Barough, Mahmoud Azami, Nima Rezaei, Sohrab Najafipour, Jafar Ai. Application of Platelet Rich Fibrin in Tissue Engineering: Focus on Bone Regeneration. Platelets 2021, 32 (2) , 183-188. https://doi.org/10.1080/09537104.2020.1869710
    58. Kai Zheng, Baiyan Sui, Kanwal Ilyas, Aldo R. Boccaccini. Porous bioactive glass micro- and nanospheres with controlled morphology: developments, properties and emerging biomedical applications. Materials Horizons 2021, 8 (2) , 300-335. https://doi.org/10.1039/D0MH01498B
    59. Weronika Prus-Walendziak, Justyna Kozlowska. Lyophilized Emulsions in the Form of 3D Porous Matrices as a Novel Material for Topical Application. Materials 2021, 14 (4) , 950. https://doi.org/10.3390/ma14040950
    60. Shadpour Mallakpour, Vajiheh Behranvand, Fereshteh Mallakpour. Physicochemical inspection and in vitro bioactivity behavior of bio-nanocomposite alginate hydrogels filled by magnesium fluoro-hydroxyapatite. Polymer Bulletin 2021, 78 (1) , 359-375. https://doi.org/10.1007/s00289-020-03111-9
    61. Deepti Rekha Sahoo, Trinath Biswal. Alginate and its application to tissue engineering. SN Applied Sciences 2021, 3 (1) https://doi.org/10.1007/s42452-020-04096-w
    62. Lukas Gritsch, Aldo R. Boccaccini. Bioactive and Biodegradable Polymer-Based Composites. 2021, 674-700. https://doi.org/10.1016/B978-0-12-803581-8.12120-4
    63. G. Karthigadevi, Carlin Geor Malar, Nibedita Dey, K. Sathish Kumar, Maria Sarah Roseline, V. Subalakshmi. Alginate-based nanocomposite hydrogels. 2021, 395-421. https://doi.org/10.1016/B978-0-12-821649-1.00008-8
    64. A. Weizel, T. Distler, D. Schneidereit, O. Friedrich, L. Bräuer, F. Paulsen, R. Detsch, A.R. Boccaccini, S. Budday, H. Seitz. Complex mechanical behavior of human articular cartilage and hydrogels for cartilage repair. Acta Biomaterialia 2020, 118 , 113-128. https://doi.org/10.1016/j.actbio.2020.10.025
    65. Fazli Wahid, Xiang-Jun Zhao, Shi-Ru Jia, He Bai, Cheng Zhong. Nanocomposite hydrogels as multifunctional systems for biomedical applications: Current state and perspectives. Composites Part B: Engineering 2020, 200 , 108208. https://doi.org/10.1016/j.compositesb.2020.108208
    66. Zhina Hadisi, Hamid Reza Bakhsheshi-Rad, Tavia Walsh, Mohammad Mehdi Dehghan, Saeed Farzad-Mohajeri, Hossein Gholami, Anahita Diyanoush, Erik Pagan, Mohsen Akbari. In vitro and in vivo evaluation of silk fibroin-hardystonite-gentamicin nanofibrous scaffold for tissue engineering applications. Polymer Testing 2020, 91 , 106698. https://doi.org/10.1016/j.polymertesting.2020.106698
    67. Ambuj Gupta, Jaykumar Bhasarkar, Mohammed Rehaan Chandan, Aabid Hussain Shaik, Bandaru Kiran, Dharmendra K. Bal. Diffusion Kinetics of Vitamin B 12 from Alginate and Poly(vinyl acetate) Based Gel Scaffolds for Targeted Drug Delivery. Journal of Macromolecular Science, Part B 2020, 59 (11) , 713-730. https://doi.org/10.1080/00222348.2020.1800246
    68. Katharina Schuhladen, Pratishtha Mukoo, Liliana Liverani, Zuzana Neščáková, Aldo R Boccaccini. Manuka honey and bioactive glass impart methylcellulose foams with antibacterial effects for wound-healing applications. Biomedical Materials 2020, 15 (6) , 065002. https://doi.org/10.1088/1748-605X/ab87e5
    69. Maryam Hajiabbas, Iran Alemzadeh, Manouchehr Vossoughi. A porous hydrogel-electrospun composite scaffold made of oxidized alginate/gelatin/silk fibroin for tissue engineering application. Carbohydrate Polymers 2020, 245 , 116465. https://doi.org/10.1016/j.carbpol.2020.116465
    70. Julius Zimmermann, Thomas Distler, Aldo R. Boccaccini, Ursula van Rienen. Numerical Simulations as Means for Tailoring Electrically Conductive Hydrogels towards Cartilage Tissue Engineering by Electrical Stimulation. Molecules 2020, 25 (20) , 4750. https://doi.org/10.3390/molecules25204750
    71. Supachai Reakasame, Anbang Jin, Kai Zheng, Muchao Qu, Aldo R. Boccaccini. Biofabrication and Characterization of Alginate Dialdehyde‐Gelatin Microcapsules Incorporating Bioactive Glass for Cell Delivery Application. Macromolecular Bioscience 2020, 20 (10) https://doi.org/10.1002/mabi.202000138
    72. Shuai Yue, Hui He, Bin Li, Tao Hou. Hydrogel as a Biomaterial for Bone Tissue Engineering: A Review. Nanomaterials 2020, 10 (8) , 1511. https://doi.org/10.3390/nano10081511
    73. R. Govindan, F.L. Gu, S. Karthi, E.K. Girija. Effect of phosphate glass reinforcement on the mechanical and biological properties of freeze-dried gelatin composite scaffolds for bone tissue engineering applications. Materials Today Communications 2020, 22 , 100765. https://doi.org/10.1016/j.mtcomm.2019.100765
    74. Aurora C. Hernández-González, Lucía Téllez-Jurado, Luis M. Rodríguez-Lorenzo. Alginate hydrogels for bone tissue engineering, from injectables to bioprinting: A review. Carbohydrate Polymers 2020, 229 , 115514. https://doi.org/10.1016/j.carbpol.2019.115514
    75. Everton Lucas de Lima, Niédja Fittipaldi Vasconcelos, Jeanny da Silva Maciel, Fábia Karine Andrade, Rodrigo Silveira Vieira, Judith Pessoa Andrade Feitosa. Injectable hydrogel based on dialdehyde galactomannan and N-succinyl chitosan: a suitable platform for cell culture. Journal of Materials Science: Materials in Medicine 2020, 31 (1) https://doi.org/10.1007/s10856-019-6343-6
    76. Basam A.E. Ben-Arfa, Ilaria E. Palamá, Isabel M. Miranda Salvado, José M.F. Ferreira, Robert C. Pullar. The role of calcium (source & content) on the in vitro behaviour of sol–gel quaternary glass series. Ceramics International 2020, 46 (1) , 1065-1075. https://doi.org/10.1016/j.ceramint.2019.09.073
    77. Serap Durkut, Yaşar Murat Elçin. Synthesis and Characterization of Thermosensitive Poly( N ‐Vinyl Caprolactam)‐Grafted‐Aminated Alginate Hydrogels. Macromolecular Chemistry and Physics 2020, 221 (2) https://doi.org/10.1002/macp.201900412
    78. Mi Li, Ning Xi, Yuechao Wang, Lianqing Liu. Tunable Hybrid Biopolymeric Hydrogel Scaffolds Based on Atomic Force Microscopy Characterizations for Tissue Engineering. IEEE Transactions on NanoBioscience 2019, 18 (4) , 597-610. https://doi.org/10.1109/TNB.2019.2922968
    79. Pallabi Pal, Quynh C. Nguyen, Angela H. Benton, Mary E. Marquart, Amol V. Janorkar. Drug‐Loaded Elastin‐Like Polypeptide–Collagen Hydrogels with High Modulus for Bone Tissue Engineering. Macromolecular Bioscience 2019, 19 (9) https://doi.org/10.1002/mabi.201900142
    80. Dongjian Shi, Jiali Shen, Zhuying Zhang, Chang Shi, Mingqing Chen, Yanglin Gu, Yang Liu. Preparation and properties of dopamine‐modified alginate/chitosan–hydroxyapatite scaffolds with gradient structure for bone tissue engineering. Journal of Biomedical Materials Research Part A 2019, 107 (8) , 1615-1627. https://doi.org/10.1002/jbm.a.36678
    81. Cheng-Hsin Cheng, Yi-Wen Chen, Alvin Kai-Xing Lee, Chun-Hsu Yao, Ming-You Shie. Development of mussel-inspired 3D-printed poly (lactic acid) scaffold grafted with bone morphogenetic protein-2 for stimulating osteogenesis. Journal of Materials Science: Materials in Medicine 2019, 30 (7) https://doi.org/10.1007/s10856-019-6279-x
    82. Ramanathan Yegappan, Vignesh Selvaprithiviraj, Sivashanmugam Amirthalingam, Annapoorna Mohandas, Nathaniel S. Hwang, R. Jayakumar. Injectable angiogenic and osteogenic carrageenan nanocomposite hydrogel for bone tissue engineering. International Journal of Biological Macromolecules 2019, 122 , 320-328. https://doi.org/10.1016/j.ijbiomac.2018.10.182
    83. Supachai Reakasame, Daniela Trapani, Rainer Detsch, Aldo R. Boccaccini. Cell laden alginate-keratin based composite microcapsules containing bioactive glass for tissue engineering applications. Journal of Materials Science: Materials in Medicine 2018, 29 (12) https://doi.org/10.1007/s10856-018-6195-5
    84. Daoyong Mao, Qing Li, Daikun Li, Ya Tan, Qijun Che. 3D porous poly(ε-caprolactone)/58S bioactive glass–sodium alginate/gelatin hybrid scaffolds prepared by a modified melt molding method for bone tissue engineering. Materials & Design 2018, 160 , 1-8. https://doi.org/10.1016/j.matdes.2018.08.062
    85. Elnaz Tamjid. Three-dimensional polycaprolactone-bioactive glass composite scaffolds: Effect of particle size and volume fraction on mechanical properties and in vitro cellular behavior. International Journal of Polymeric Materials and Polymeric Biomaterials 2018, 67 (17) , 1005-1015. https://doi.org/10.1080/00914037.2017.1417285
    86. Kuo-Hao Huang, Yen-Hong Lin, Ming-You Shie, Chun-Pin Lin. Effects of bone morphogenic protein-2 loaded on the 3D-printed MesoCS scaffolds. Journal of the Formosan Medical Association 2018, 117 (10) , 879-887. https://doi.org/10.1016/j.jfma.2018.07.010
    87. Ulrike Rottensteiner-Brandl, Rainer Detsch, Bapi Sarker, Lara Lingens, Katrin Köhn, Ulrich Kneser, Anja Bosserhoff, Raymund Horch, Aldo Boccaccini, Andreas Arkudas. Encapsulation of Rat Bone Marrow Derived Mesenchymal Stem Cells in Alginate Dialdehyde/Gelatin Microbeads with and without Nanoscaled Bioactive Glass for In Vivo Bone Tissue Engineering. Materials 2018, 11 (10) , 1880. https://doi.org/10.3390/ma11101880
    88. Quan Shi, Zhi‐Yong Li, Liliana Liverani, Judith Roether, Qiang Chen, Aldo R. Boccaccini. Positive effect of wrapping poly caprolactone/polyethylene glycol fibrous films on the mechanical properties of 45S5 bioactive glass scaffolds. International Journal of Applied Ceramic Technology 2018, 15 (4) , 921-929. https://doi.org/10.1111/ijac.12899
    89. Yannan Li, Yi Guo, Juan Ge, Peter X. Ma, Bo Lei. In situ silica nanoparticles-reinforced biodegradable poly(citrate-siloxane) hybrid elastomers with multifunctional properties for simultaneous bioimaging and bone tissue regeneration. Applied Materials Today 2018, 10 , 153-163. https://doi.org/10.1016/j.apmt.2017.11.007
    90. Neda Arabi, Ali Zamanian, Sarvenaz N. Rashvand, Farnaz Ghorbani. The Tunable Porous Structure of Gelatin-Bioglass Nanocomposite Scaffolds for Bone Tissue Engineering Applications: Physicochemical, Mechanical, and In Vitro Properties. Macromolecular Materials and Engineering 2018, 303 (3) , 1700539. https://doi.org/10.1002/mame.201700539
    91. Bapi Sarker, Aldo R. Boccaccini. Alginate Utilization in Tissue Engineering and Cell Therapy. 2018, 121-155. https://doi.org/10.1007/978-981-10-6910-9_5
    92. Cong Shan, ZhongXu Li, LianXu Wang, Xiuwen Su, Fengwei Shi, Jianglei Hu. High strength and catalytic activity of polyacrylamide/graphene oxide porous metal alginates aerogels for phenol hydroxylation with H2O2. Catalysis Communications 2017, 101 , 116-119. https://doi.org/10.1016/j.catcom.2017.08.011
    93. Laura M. Henning, Sara Zavareh, Paul H. Kamm, Miriam Höner, Horst Fischer, John Banhart, Franziska Schmidt, Aleksander Gurlo. Manufacturing and Characterization of Highly Porous Bioactive Glass Composite Scaffolds Using Unidirectional Freeze Casting . Advanced Engineering Materials 2017, 19 (10) , 1700129. https://doi.org/10.1002/adem.201700129
    94. Yuan-Chien Chen, Ming-You Shie, Yuan-Haw Andrew Wu, Kai-Xing Alvin Lee, Li-Ju Wei, Yu-Fang Shen. Anti-inflammation performance of curcumin-loaded mesoporous calcium silicate cement. Journal of the Formosan Medical Association 2017, 116 (9) , 679-688. https://doi.org/10.1016/j.jfma.2017.06.005
    95. Kunyu Zhang, Qian Feng, Jianbin Xu, Xiayi Xu, Feng Tian, Kelvin W. K. Yeung, Liming Bian. Self‐Assembled Injectable Nanocomposite Hydrogels Stabilized by Bisphosphonate‐Magnesium (Mg 2+ ) Coordination Regulates the Differentiation of Encapsulated Stem Cells via Dual Crosslinking. Advanced Functional Materials 2017, 27 (34) https://doi.org/10.1002/adfm.201701642
    Download PDF

    Pair your accounts.

    Export articles to Mendeley

    Get article recommendations from ACS based on references in your Mendeley library.

    Pair your accounts.

    Export articles to Mendeley

    Get article recommendations from ACS based on references in your Mendeley library.

    You’ve supercharged your research process with ACS and Mendeley!

    STEP 1:
    Click to create an ACS ID

    Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

    Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

    Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

    MENDELEY PAIRING EXPIRED
    Your Mendeley pairing has expired. Please reconnect