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Thermosensitive Polymer Biocompatibility Based on Interfacial Structure at Biointerface

  • Daiki Murakami*
    Daiki Murakami
    Institute for Materials Chemistry  and  Engineering Graduate School of Engineering, Kyushu University, CE41, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan
    *E-mail: [email protected] (D.M.).
  • Yoko Kitahara
    Yoko Kitahara
    Engineering Graduate School of Engineering, Kyushu University, CE41, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan
  • Shingo Kobayashi
    Shingo Kobayashi
    Institute for Materials Chemistry, Kyushu University, CE41, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan
    Frontier Center for Organic System Innovations, Yamagata University, 4-3-16 Jonan, Yonezawa, Yamagata 992-8510, Japan
  • , and 
  • Masaru Tanaka*
    Masaru Tanaka
    Institute for Materials Chemistry  and  Engineering Graduate School of Engineering, Kyushu University, CE41, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan
    Frontier Center for Organic System Innovations, Yamagata University, 4-3-16 Jonan, Yonezawa, Yamagata 992-8510, Japan
    *E-mail: [email protected] (M.T.).
Cite this: ACS Biomater. Sci. Eng. 2018, 4, 5, 1591–1597
Publication Date (Web):April 12, 2018
https://doi.org/10.1021/acsbiomaterials.8b00081
Copyright © 2018 American Chemical Society

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    Abstract

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    The interfacial structure of a thermosensitive biocompatible polymer, poly[2-(2-methoxyethoxy)ethyl methacrylate] (PMe2MA), at the polymer/phosphate-buffered saline (PBS) interface was investigated by atomic force microscopy. A number of nanometer scale protrusions appeared at 37 °C and disappeared at 22 °C, reversibly. This structural change occurred above the lower critical solution temperature of PMe2MA in PBS (19 °C), indicating that the formation of protrusions was explained by the microphase separation of polymer and water at the interfacial region. The protein adsorption and platelet adhesion onto PMe2MA interface were drastically restrained at 22 °C compared to that at 37 °C. Detachment of NIH3T3 cells accompanied by the dissipation of protrusions on the PMe2MA interface was also demonstrated. These results indicate that the protrusions act as the scaffold for the protein adsorption and cell adhesion.

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    The Supporting Information is available free of charge on the ACS Publications website at DOI: 10.1021/acsbiomaterials.8b00081.

    • Temperature dependence of AFM topographic images of PMEA in PBS (PDF)

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    Cited By

    This article is cited by 12 publications.

    1. Takuma Kanamaru, Masataka Araki, Rintaro Takahashi, Shota Fujii, Toshiyuki Shikata, Daiki Murakami, Masaru Tanaka, Kazuo Sakurai. First Observation of the Hydration Layer around Polymer Chain by Scattering and Its Relationship to Thromboresistance: Dilute Solution Properties of PMEA in THF/Water. The Journal of Physical Chemistry B 2021, 125 (26) , 7251-7261. https://doi.org/10.1021/acs.jpcb.1c01864
    2. An-Tsung Kuo, Shingo Urata, Ryohei Koguchi, Toshiki Sonoda, Shingo Kobayashi, Masaru Tanaka. Molecular Dynamics Study on the Water Mobility and Side-Chain Flexibility of Hydrated Poly(ω-methoxyalkyl acrylate)s. ACS Biomaterials Science & Engineering 2020, 6 (12) , 6690-6700. https://doi.org/10.1021/acsbiomaterials.0c01220
    3. Katja Jankova, Irakli Javakhishvili, Shingo Kobayashi, Ryohei Koguchi, Daiki Murakami, Toshiki Sonoda, Masaru Tanaka. Hydration States and Blood Compatibility of Hydrogen-Bonded Supramolecular Poly(2-methoxyethyl acrylate). ACS Applied Bio Materials 2019, 2 (10) , 4154-4161. https://doi.org/10.1021/acsabm.9b00363
    4. Nicolas Marets, Shuhei Kanno, Shuhei Ogata, Ayumi Ishii, Shogo Kawaguchi, Miki Hasegawa. Lanthanide-Oligomeric Brush Films: From Luminescence Properties to Structure Resolution. ACS Omega 2019, 4 (13) , 15512-15520. https://doi.org/10.1021/acsomega.9b01775
    5. Ryohei Koguchi, Katja Jankova, Noriko Tanabe, Yosuke Amino, Yuki Hayasaka, Daisuke Kobayashi, Tatsuya Miyajima, Kyoko Yamamoto, Masaru Tanaka. Controlling the Hydration Structure with a Small Amount of Fluorine To Produce Blood Compatible Fluorinated Poly(2-methoxyethyl acrylate). Biomacromolecules 2019, 20 (6) , 2265-2275. https://doi.org/10.1021/acs.biomac.9b00201
    6. Daiki Murakami, Nami Mawatari, Toshiki Sonoda, Aki Kashiwazaki, Masaru Tanaka. Effect of the Molecular Weight of Poly(2-methoxyethyl acrylate) on Interfacial Structure and Blood Compatibility. Langmuir 2019, 35 (7) , 2808-2813. https://doi.org/10.1021/acs.langmuir.8b02971
    7. Shin-nosuke Nishimura, Masaru Tanaka. The Intermediate Water Concept for Pioneering Polymeric Biomaterials: A Review and Update. Bulletin of the Chemical Society of Japan 2023, 96 (9) , 1052-1070. https://doi.org/10.1246/bcsj.20230168
    8. Md Azizul Haque, Daiki Murakami, Masaru Tanaka. Cell Adhesion Strength Indicates the Antithrombogenicity of Poly(2-methoxyethyl acrylate) (PMEA): Potential Candidate for Artificial Small-Diameter Blood Vessel. Surfaces 2022, 5 (3) , 365-382. https://doi.org/10.3390/surfaces5030027
    9. Md Azizul Haque, Daiki Murakami, Takahisa Anada, Masaru Tanaka. Poly(2-Methoxyethyl Acrylate) (PMEA)-Coated Anti-Platelet Adhesive Surfaces to Mimic Native Blood Vessels through HUVECs Attachment, Migration, and Monolayer Formation. Coatings 2022, 12 (6) , 869. https://doi.org/10.3390/coatings12060869
    10. Luis Castillo-Henríquez, Jose Castro-Alpízar, Mary Lopretti-Correa, José Vega-Baudrit. Exploration of Bioengineered Scaffolds Composed of Thermo-Responsive Polymers for Drug Delivery in Wound Healing. International Journal of Molecular Sciences 2021, 22 (3) , 1408. https://doi.org/10.3390/ijms22031408
    11. Payam Zarrintaj, Maryam Jouyandeh, Mohammad Reza Ganjali, Behzad Shirkavand Hadavand, Masoud Mozafari, Sergei S. Sheiko, Mohammad Vatankhah-Varnoosfaderani, Tomy J. Gutiérrez, Mohammad Reza Saeb. Thermo-sensitive polymers in medicine: A review. European Polymer Journal 2019, 117 , 402-423. https://doi.org/10.1016/j.eurpolymj.2019.05.024
    12. Tomoya Ueda, Daiki Murakami, Masaru Tanaka. Analysis of Interaction Between Interfacial Structure and Fibrinogen at Blood-Compatible Polymer/Water Interface. Frontiers in Chemistry 2018, 6 https://doi.org/10.3389/fchem.2018.00542

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