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Download Hi-Res ImageDownload to MS-PowerPointCite This:ACS Biomater. Sci. Eng. 2019, 5, 5, 2343-2354
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Development of Zoledronic Acid-Based Nanoassemblies for Bone-Targeted Anticancer Therapy

  • Elham Hatami
    Elham Hatami
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, 881 Madison Avenue, Memphis, Tennessee 38163, United States
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    • , 
  • Prashanth Kumar Bhusetty Nagesh
    Prashanth Kumar Bhusetty Nagesh
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, 881 Madison Avenue, Memphis, Tennessee 38163, United States
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    • , 
  • Pallabita Chowdhury
    Pallabita Chowdhury
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, 881 Madison Avenue, Memphis, Tennessee 38163, United States
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    • , 
  • Stacie Elliot
    Stacie Elliot
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, 881 Madison Avenue, Memphis, Tennessee 38163, United States
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    • , 
  • Deanna Shields
    Deanna Shields
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, 881 Madison Avenue, Memphis, Tennessee 38163, United States
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    • , 
  • Subhash Chand Chauhan
    Subhash Chand Chauhan
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, 881 Madison Avenue, Memphis, Tennessee 38163, United States
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    • , 
  • Meena Jaggi
    Meena Jaggi
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, 881 Madison Avenue, Memphis, Tennessee 38163, United States
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    • , and 
  • Murali Mohan Yallapu*
    Murali Mohan Yallapu
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, 881 Madison Avenue, Memphis, Tennessee 38163, United States
    *E-mail: [email protected]. Phone: (901) 448-1536. Fax: (901) 448-3446.
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Cite this: ACS Biomater. Sci. Eng. 2019, 5, 5, 2343–2354
Publication Date (Web):March 27, 2019
https://doi.org/10.1021/acsbiomaterials.9b00362
Copyright © 2019 American Chemical Society
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Abstract

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Bone metastasis occurs in the majority of cancer patients, which hampers quality of life and significantly decreases survival. Aggressive chemotherapy is a traditional treatment regimen that induces severe systemic toxicities. Therefore, bone-directed therapies are highly warranted. We report a novel nanoparticle formulation that is composed of poly(vinylpyrrolidone) and tannic acid core nanoparticles (PVT NPs) that forms self-assembly with zoledronic acid ([email protected] NPs). The construction of [email protected] NPs was confirmed by particle size, zeta potential, transmission electron microscopy, and spectral analyses. An optimized bone-targeted [email protected] NPs formulation showed greater binding and internalization in in vitro with metastasis prostate and breast cancer cells. [email protected] NPs were able to deliver ZA more efficiently to tumor cells, which inhibited proliferation of human prostate and breast cancer cells. In addition, [email protected] NPs were capable of targeting mouse bones and prostate tumor microarray tissues (ex vivo) while sparing all other vital organs. More importantly, [email protected] NPs induce chemo sensitization to docetaxel treatment in cancer cells. Overall, the study results confirm that ZA-based, bone-targeted NPs have great potential for the treatment of bone metastasis in the near future.

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Cited By

This article is cited by 1 publications.

  1. Shijie Wang, Dingyao Gao, Ke Li, Siqin Ye, Qingzhu Liu, Ying Peng, Gaochao Lv, Ling Qiu, Jianguo Lin. Radiopharmacological evaluation of a caspase-3 responsive probe with optimized pharmacokinetics for PET imaging of tumor apoptosis. Organic & Biomolecular Chemistry 2020, 18 (18) , 3512-3521. https://doi.org/10.1039/D0OB00690D

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