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    “Nano”: An Emerging Avenue in Electrochemical Detection of Neurotransmitters
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    • Sasya Madhurantakam*
      Sasya Madhurantakam
      Department of Molecular Physiology, Niigata University School of Medicine, Niigata 951-8510, Japan
      *(S.M.) Email: [email protected]
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    • Jayanth Babu Karnam
      Jayanth Babu Karnam
      School of Electrical and Electronics Engineering, SASTRA Deemed University, Thanjavur 613401, India
      Centre for Nanotechnology and Advanced Biomaterials (CeNTAB), SASTRA Deemed University, Thanjavur 613401, India
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    • Dermot Brabazon
      Dermot Brabazon
      I-Form, Advanced Manufacturing Research Centre, Advanced Processing Technology Research Centre, Dublin City University, Dublin, Ireland
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      Orcidhttp://orcid.org/0000-0003-3214-6381
    • Madoka Takai
      Madoka Takai
      Department of Bioengineering, The University of Tokyo, Bunkyo-ku, Tokyo, Japan
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      Orcidhttp://orcid.org/0000-0002-6238-6717
    • Inam Ul Ahad
      Inam Ul Ahad
      I-Form, Advanced Manufacturing Research Centre, Advanced Processing Technology Research Centre, Dublin City University, Dublin, Ireland
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    • John Bosco Balaguru Rayappan
      John Bosco Balaguru Rayappan
      School of Electrical and Electronics Engineering, SASTRA Deemed University, Thanjavur 613401, India
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      Orcidhttp://orcid.org/0000-0003-4641-9870
    • Uma Maheswari Krishnan*
      Uma Maheswari Krishnan
      Centre for Nanotechnology and Advanced Biomaterials (CeNTAB), SASTRA Deemed University, Thanjavur 613401, India
      School of Arts, Science & Humanities, SASTRA Deemed University, Thanjavur 613401, India
      *(U.M.K.) Phone: +(91) 4362 264101 Ext: 3677. Email: [email protected]
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      Orcidhttp://orcid.org/0000-0001-6508-4485
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    ACS Chemical Neuroscience

    Cite this: ACS Chem. Neurosci. 2020, 11, 24, 4024–4047
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    https://doi.org/10.1021/acschemneuro.0c00355
    Published December 7, 2020
    Copyright © 2020 American Chemical Society
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    Abstract

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    The growing importance of nanomaterials toward the detection of neurotransmitter molecules has been chronicled in this review. Neurotransmitters (NTs) are chemicals that serve as messengers in synaptic transmission and are key players in brain functions. Abnormal levels of NTs are associated with numerous psychotic and neurodegenerative diseases. Therefore, their sensitive and robust detection is of great significance in clinical diagnostics. For more than three decades, electrochemical sensors have made a mark toward clinical detection of NTs. The superiority of these electrochemical sensors lies in their ability to enable sensitive, simple, rapid, and selective determination of analyte molecules while remaining relatively inexpensive. Additionally, these sensors are capable of being integrated in robust, portable, and miniaturized devices to establish point-of-care diagnostic platforms. Nanomaterials have emerged as promising materials with significant implications for electrochemical sensing due to their inherent capability to achieve high surface coverage, superior sensitivity, and rapid response in addition to simple device architecture and miniaturization. Considering the enormous significance of the levels of NTs in biological systems and the advances in sensing ushered in with the integration of nanotechnology in electrochemistry, the analysis of NTs by employing nanomaterials as interface materials in various matrices has emerged as an active area of research. This review explores the advancements made in the field of electrochemical sensors for the sensitive and selective determination of NTs which have been described in the past two decades with a distinctive focus on extremely innovative attributes introduced by nanotechnology.

    Copyright © 2020 American Chemical Society

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    ACS Chemical Neuroscience

    Cite this: ACS Chem. Neurosci. 2020, 11, 24, 4024–4047
    Click to copy citationCitation copied!
    https://doi.org/10.1021/acschemneuro.0c00355
    Published December 7, 2020
    Copyright © 2020 American Chemical Society
    Request reuse permissions

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