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Altered Expression Levels of MicroRNA-132 and Nurr1 in Peripheral Blood of Parkinson’s Disease: Potential Disease Biomarkers

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    Research Article

    Altered Expression Levels of MicroRNA-132 and Nurr1 in Peripheral Blood of Parkinson’s Disease: Potential Disease Biomarkers
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    • Zhaofei Yang
      Zhaofei Yang
      Department of Occupational and Environmental Health, Dalian Medical University, Dalian 116044, China
      Center for Clinical Research on Neurological Diseases, the First Affiliated Hospital, Dalian Medical University, Dalian 116021, China
      Liaoning Provincial Key Laboratory for Research on the Pathogenic Mechanisms of Neurological Diseases, the First Affiliated Hospital, Dalian Medical University, Dalian 116021, China
      More by Zhaofei Yang
    • Tianbai Li
      Tianbai Li
      Center for Clinical Research on Neurological Diseases, the First Affiliated Hospital, Dalian Medical University, Dalian 116021, China
      Liaoning Provincial Key Laboratory for Research on the Pathogenic Mechanisms of Neurological Diseases, the First Affiliated Hospital, Dalian Medical University, Dalian 116021, China
      More by Tianbai Li
    • Song Li
      Song Li
      Center for Clinical Research on Neurological Diseases, the First Affiliated Hospital, Dalian Medical University, Dalian 116021, China
      Liaoning Provincial Key Laboratory for Research on the Pathogenic Mechanisms of Neurological Diseases, the First Affiliated Hospital, Dalian Medical University, Dalian 116021, China
      More by Song Li
    • Min Wei
      Min Wei
      Center for Clinical Research on Neurological Diseases, the First Affiliated Hospital, Dalian Medical University, Dalian 116021, China
      Liaoning Provincial Key Laboratory for Research on the Pathogenic Mechanisms of Neurological Diseases, the First Affiliated Hospital, Dalian Medical University, Dalian 116021, China
      More by Min Wei
    • Hongqian Qi
      Hongqian Qi
      Center for Clinical Research on Neurological Diseases, the First Affiliated Hospital, Dalian Medical University, Dalian 116021, China
      Liaoning Provincial Key Laboratory for Research on the Pathogenic Mechanisms of Neurological Diseases, the First Affiliated Hospital, Dalian Medical University, Dalian 116021, China
      More by Hongqian Qi
    • Bairong Shen
      Bairong Shen
      Institute for Systems Genetics, West China Hospital, Sichuan University, Chengdu 610041, China
      More by Bairong Shen
      Orcidhttp://orcid.org/0000-0003-2899-1531
    • Raymond Chuen-Chung Chang
      Raymond Chuen-Chung Chang
      Laboratory of Neurodegenerative Diseases, LKS Faculty of Medicine, School of Biomedical Sciences, The University of Hong Kong, Hong Kong, China
      More by Raymond Chuen-Chung Chang
      Orcidhttp://orcid.org/0000-0001-8538-7993
    • Weidong Le*
      Weidong Le
      Center for Clinical Research on Neurological Diseases, the First Affiliated Hospital, Dalian Medical University, Dalian 116021, China
      Liaoning Provincial Key Laboratory for Research on the Pathogenic Mechanisms of Neurological Diseases, the First Affiliated Hospital, Dalian Medical University, Dalian 116021, China
      *E-mail: [email protected] (W.L.).
      More by Weidong Le
      Orcidhttp://orcid.org/0000-0001-7459-2705
    • Fengyuan Piao*
      Fengyuan Piao
      Department of Occupational and Environmental Health, Dalian Medical University, Dalian 116044, China
      *E-mail: [email protected] (F.P.).
      More by Fengyuan Piao
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    ACS Chemical Neuroscience

    Cite this: ACS Chem. Neurosci. 2019, 10, 5, 2243–2249
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    https://doi.org/10.1021/acschemneuro.8b00460
    Published February 28, 2019
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    Abstract

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    MicroRNAs (miRNAs) are small and evolutionary conserved noncoding RNAs that are involved in post-transcriptional gene regulation. Differential expression levels of miRNAs can be used as potential biomarkers of disease. Previous animal studies have indicated that the expression level of miR-132 is negatively correlated with its downstream molecule nuclear receptor related 1 protein (Nurr1), which is one of the key factors for the maintenance of dopaminergic function and is particularly vulnerable in Parkinson’s disease (PD). However, this correlation has not been confirmed in human patients with PD. Moreover, the possible involvement of miR-132 during the pathogenesis and progression of PD is not fully investigated. Therefore, in the present study, we determined the peripheral circulation levels of miR-132 and Nurr1 in patients with PD, neurological disease controls (NDC) and healthy controls (HC) by reverse transcription real-time quantitative PCR (RT-qPCR). Our data clearly demonstrated that the plasma miR-132 level in PD was significantly higher than those in HC (178%, p < 0.05) and NDC (188%, p < 0.001). When adjusted for gender and age, higher level of miR-132 expression was associated with the significantly increased risk for PD in males and was closely related with the disease stages and disease severity. Furthermore, peripheral Nurr1 was significantly decreased in PD compared with HC (56%, p < 0.001) and NDC (58%, p < 0.001). Much more interestingly, further analysis revealed a negative correlation between the decreased Nurr1 level and the elevated miR-132 level in PD. All these findings indicated that the combination of a high miR-132 level with the low level of its downstream Nurr1 might be a potential biomarker aiding in the diagnosis of PD and monitoring disease progression.

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    The Supporting Information is available free of charge on the ACS Publications website at DOI: 10.1021/acschemneuro.8b00460.

    • Effect of miR-132 on Nurr1 expression in cultured PBL and effect of medications on the Nurr1 expression in PBL of PD patients (PDF)

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    ACS Chemical Neuroscience

    Cite this: ACS Chem. Neurosci. 2019, 10, 5, 2243–2249
    Click to copy citationCitation copied!
    https://doi.org/10.1021/acschemneuro.8b00460
    Published February 28, 2019
    Copyright © 2019 American Chemical Society
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