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High-Resolution Shortwave Infrared Imaging of Vascular Disorders Using Gold Nanoclusters

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    High-Resolution Shortwave Infrared Imaging of Vascular Disorders Using Gold Nanoclusters
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    • Zhixi Yu
      Zhixi Yu
      Cancer Targets and Experimental Therapeutics, Institute for Advanced Biosciences (IAB), University of Grenoble Alpes (UGA)/ INSERM-U1209/CNRS-UMR 5309, 38700 Grenoble, France
      More by Zhixi Yu
    • Benjamin Musnier
      Benjamin Musnier
      Cancer Targets and Experimental Therapeutics, Institute for Advanced Biosciences (IAB), University of Grenoble Alpes (UGA)/ INSERM-U1209/CNRS-UMR 5309, 38700 Grenoble, France
      More by Benjamin Musnier
    • K. David Wegner
      K. David Wegner
      BAM Federal Institute for Materials Research and Testing, Richard-Willstaetter-Str. 11, 12489 Berlin, Germany
      More by K. David Wegner
    • Maxime Henry
      Maxime Henry
      Cancer Targets and Experimental Therapeutics, Institute for Advanced Biosciences (IAB), University of Grenoble Alpes (UGA)/ INSERM-U1209/CNRS-UMR 5309, 38700 Grenoble, France
      More by Maxime Henry
    • Benoit Chovelon
      Benoit Chovelon
      Institut de Biologie et Pathologie, Centre Hospitalier Universitaire (CHU) de Grenoble Alpes, 38700 Grenoble, France
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    • Agnès Desroches-Castan
      Agnès Desroches-Castan
      Biology of Cancer and Infection Laboratory, University Grenoble Alpes, INSERM, CEA, 38000 Grenoble, France
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    • Arnold Fertin
      Arnold Fertin
      TIMC-IMAG Laboratory, University of Grenoble Alpes, CNRS-UMR 5525, 38700 Grenoble, France
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    • Ute Resch-Genger
      Ute Resch-Genger
      BAM Federal Institute for Materials Research and Testing, Richard-Willstaetter-Str. 11, 12489 Berlin, Germany
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      Orcidhttp://orcid.org/0000-0002-0944-1115
    • Sabine Bailly
      Sabine Bailly
      Biology of Cancer and Infection Laboratory, University Grenoble Alpes, INSERM, CEA, 38000 Grenoble, France
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    • Jean-Luc Coll*
      Jean-Luc Coll
      Cancer Targets and Experimental Therapeutics, Institute for Advanced Biosciences (IAB), University of Grenoble Alpes (UGA)/ INSERM-U1209/CNRS-UMR 5309, 38700 Grenoble, France
      *Email: [email protected]
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      Orcidhttp://orcid.org/0000-0002-2453-3552
    • Yves Usson
      Yves Usson
      TIMC-IMAG Laboratory, University of Grenoble Alpes, CNRS-UMR 5525, 38700 Grenoble, France
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    • Véronique Josserand
      Véronique Josserand
      Cancer Targets and Experimental Therapeutics, Institute for Advanced Biosciences (IAB), University of Grenoble Alpes (UGA)/ INSERM-U1209/CNRS-UMR 5309, 38700 Grenoble, France
      More by Véronique Josserand
    • Xavier Le Guével*
      Xavier Le Guével
      Cancer Targets and Experimental Therapeutics, Institute for Advanced Biosciences (IAB), University of Grenoble Alpes (UGA)/ INSERM-U1209/CNRS-UMR 5309, 38700 Grenoble, France
      *Email: [email protected]
      More by Xavier Le Guével
      Orcidhttp://orcid.org/0000-0003-3634-7762
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    ACS Nano

    Cite this: ACS Nano 2020, 14, 4, 4973–4981
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    https://doi.org/10.1021/acsnano.0c01174
    Published March 25, 2020
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    Abstract

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    We synthesized a generation of water-soluble, atomically precise gold nanoclusters (Au NCs) with anisotropic surface containing a short dithiol pegylated chain (AuMHA/TDT). The AuMHA/TDT exhibit a high brightness (QY ∼ 6%) in the shortwave infrared (SWIR) spectrum with a detection above 1250 nm. Furthermore, they show an extended half-life in blood (t1/2ß = 19.54 ± 0.05 h) and a very weak accumulation in organs. We also developed a non-invasive, whole-body vascular imaging system in the SWIR window with high-resolution, benefiting from a series of Monte Carlo image processing. The imaging process enabled to improve contrast by 1 order of magnitude and enhance the spatial resolution by 59%. After systemic administration of these nanoprobes in mice, we can quantify vessel complexity in depth (>4 mm), allowing to detect very subtle vascular disorders non-invasively in bone morphogenetic protein 9 (Bmp9)-deficient mice. The combination of these anisotropic surface charged Au NCs plus an improved SWIR imaging device allows a precise mapping at high-resolution and an in depth understanding of the organization of the vascular network in live animals.

    Copyright © 2020 American Chemical Society

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    Supporting Information

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    The Supporting Information is available free of charge at https://pubs.acs.org/doi/10.1021/acsnano.0c01174.

    • Physicochemical and photophysical of Au NCs, cytotoxicity, and additional in vivo experiments in mice (PDF)

    • Movie S1: In vivo SWIR imaging of WT 129/Ola mice vasculature (AVI)

    • Movie S2: Comparison of in vivo SWIR imaging of WT 129/Ola mice vasculature after imaging processing (MCR; MCR + HP filtering) (AVI)

    • Movie S3: In vivo SWIR imaging (MCR + HP filtering) after injection (AVI)

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    Cite this: ACS Nano 2020, 14, 4, 4973–4981
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