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Bioresorbable, Miniaturized Porous Silicon Needles on a Flexible Water-Soluble Backing for Unobtrusive, Sustained Delivery of Chemotherapy

  • Hyungjun Kim
    Hyungjun Kim
    Weldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana 47907, United States
    Department of Industrial and Physical Pharmacy, Purdue University, West Lafayette, Indiana 47907, United States
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  • , 
  • Heung Soo Lee
    Heung Soo Lee
    School of Mechanical Engineering, Hanyang University, Seoul, South Korea
    More by Heung Soo Lee
    Orcidhttp://orcid.org/0000-0002-9393-0121
  • , 
  • Yale Jeon
    Yale Jeon
    School of Mechanical Engineering, Hanyang University, Seoul, South Korea
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  • , 
  • Woohyun Park
    Woohyun Park
    School of Mechanical Engineering, Purdue University, West Lafayette, Indiana 47907, United States
    More by Woohyun Park
  • , 
  • Yue Zhang
    Yue Zhang
    Department of Mechanical and Aerospace Engineering, University of Virginia, Charlottesville, Virginia 22904, United States
    More by Yue Zhang
  • , 
  • Bongjoong Kim
    Bongjoong Kim
    School of Mechanical Engineering, Purdue University, West Lafayette, Indiana 47907, United States
    More by Bongjoong Kim
    Orcidhttp://orcid.org/0000-0002-9969-6954
  • , 
  • Hanmin Jang
    Hanmin Jang
    School of Mechanical Engineering, Hanyang University, Seoul, South Korea
    More by Hanmin Jang
    Orcidhttp://orcid.org/0000-0002-7724-4244
  • , 
  • Baoxing Xu
    Baoxing Xu
    Department of Mechanical and Aerospace Engineering, University of Virginia, Charlottesville, Virginia 22904, United States
    More by Baoxing Xu
    Orcidhttp://orcid.org/0000-0002-2591-8737
  • , 
  • Yoon Yeo*
    Yoon Yeo
    Department of Industrial and Physical Pharmacy, Purdue University, West Lafayette, Indiana 47907, United States
    *Email: [email protected]
    More by Yoon Yeo
    Orcidhttp://orcid.org/0000-0001-9505-7701
  • , 
  • Dong Rip Kim*
    Dong Rip Kim
    School of Mechanical Engineering, Hanyang University, Seoul, South Korea
    *Email: [email protected]
    More by Dong Rip Kim
    Orcidhttp://orcid.org/0000-0001-6398-9483
  • , and 
  • Chi Hwan Lee*
    Chi Hwan Lee
    Weldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana 47907, United States
    School of Mechanical Engineering, Purdue University, West Lafayette, Indiana 47907, United States
    School of Materials Engineering, Purdue University, West Lafayette, Indiana 47907, United States
    Department of Speech, Language, and Hearing Sciences, Purdue University, West Lafayette, Indiana 47907, United States
    *Email: [email protected]
    More by Chi Hwan Lee
    Orcidhttp://orcid.org/0000-0002-4868-7054
Cite this: ACS Nano 2020, 14, 6, 7227–7236
Publication Date (Web):May 13, 2020
https://doi.org/10.1021/acsnano.0c02343
Copyright © 2020 American Chemical Society
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    Abstract

    Abstract Image

    Conventional melanoma therapies suffer from the toxicity and side effects of repeated treatments due to the aggressive and recurrent nature of melanoma cells. Less-invasive topical chemotherapies by utilizing polymeric microneedles have emerged as an alternative, but the sustained, long-lasting release of drug cargos remains challenging. In addition, the size of the microneedles is relatively bulky for the small, curvilinear, and exceptionally sensitive cornea for the treatment of ocular melanoma. Here, we report a design of bioresorbable, miniaturized porous-silicon (p-Si) needles with covalently linked drug cargos at doses comparable to those of conventional polymeric microneedles. The p-Si needles are built on a water-soluble film as a temporary flexible holder that can be intimately interfaced with the irregular surface of living tissues, followed by complete dissolution with saline solution within 1 min. Consequently, the p-Si needles remain embedded inside tissues and then undergo gradual degradation, allowing for sustained release of the drug cargos. Its utility in unobtrusive topical delivery of chemotherapy with minimal side effects is demonstrated in a murine melanoma model.

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    The Supporting Information is available free of charge at https://pubs.acs.org/doi/10.1021/acsnano.0c02343.

    • Visual observation (16× speed) of a yellow-colored PVA immersed in a solution of PBS (pH 7.4) at 37.5 °C (MP4)

    • Real-time demonstration of the automated peeling of the p-Si needles from the donor Si wafer (MP4)

    • Demonstration (26× speed) of the nanoinjection of DOX to the shaved skin of a mouse after 2 h of subcutaneous inoculation with 1 × 106 B16F10 melanoma cells (MP4)

    • Visual observation (2× speed) of a mouse receiving an array (1 × 1 cm2) of the p-Si needles with covalently linked (amide) DOX on the back side (MP4)

    • SEM images, optical images, FEA results, MTT assay results, microscope images, schematic diagrams, measurement results (PDF)

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    Most electronic Supporting Information files are available without a subscription to ACS Web Editions. Such files may be downloaded by article for research use (if there is a public use license linked to the relevant article, that license may permit other uses). Permission may be obtained from ACS for other uses through requests via the RightsLink permission system: http://pubs.acs.org/page/copyright/permissions.html.

    Cited By

    This article is cited by 46 publications.

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    2. Yamin Zhang, Geumbee Lee, Shuo Li, Ziying Hu, Kaiyu Zhao, John A. Rogers. Advances in Bioresorbable Materials and Electronics. Chemical Reviews 2023, 123 (19) , 11722-11773. https://doi.org/10.1021/acs.chemrev.3c00408
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    5. Yonghwan Lee, Hark Hoe Tan, Chennupati Jagadish, Siva Krishna Karuturi. Controlled Cracking for Large-Area Thin Film Exfoliation: Working Principles, Status, and Prospects. ACS Applied Electronic Materials 2021, 3 (1) , 145-162. https://doi.org/10.1021/acsaelm.0c00892
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