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Natural-Killer-Cell-Inspired Nanorobots with Aggregation-Induced Emission Characteristics for Near-Infrared-II Fluorescence-Guided Glioma Theranostics

  • Guanjun Deng
    Guanjun Deng
    Guangdong Key Laboratory of Nanomedicine, CAS-HK Joint Lab of Biomaterials, Shenzhen Engineering Laboratory of Nanomedicine and Nanoformulations, CAS Key Laboratory of Health Informatics, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China
    Department of Chemistry, Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction and Institute for Advanced Study, The Hong Kong University of Science and Technology (HKUST), Clear Water Bay, Kowloon, Hong Kong, China
    More by Guanjun Deng
    • , 
  • Xinghua Peng
    Xinghua Peng
    Guangdong Key Laboratory of Nanomedicine, CAS-HK Joint Lab of Biomaterials, Shenzhen Engineering Laboratory of Nanomedicine and Nanoformulations, CAS Key Laboratory of Health Informatics, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China
    More by Xinghua Peng
    • , 
  • Zhihong Sun
    Zhihong Sun
    Guangdong Key Laboratory of Nanomedicine, CAS-HK Joint Lab of Biomaterials, Shenzhen Engineering Laboratory of Nanomedicine and Nanoformulations, CAS Key Laboratory of Health Informatics, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China
    Department of Chemistry, Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction and Institute for Advanced Study, The Hong Kong University of Science and Technology (HKUST), Clear Water Bay, Kowloon, Hong Kong, China
    More by Zhihong Sun
    • , 
  • Wei Zheng
    Wei Zheng
    Laboratory for Biomedical Optics and Molecular Imaging, Shenzhen Key Laboratory for Molecular Imaging, CAS Key Lab for Health Informatics, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China
    More by Wei Zheng
    • , 
  • Jia Yu
    Jia Yu
    Laboratory for Biomedical Optics and Molecular Imaging, Shenzhen Key Laboratory for Molecular Imaging, CAS Key Lab for Health Informatics, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China
    More by Jia Yu
    • , 
  • Lulu Du
    Lulu Du
    Key Laboratory of Environmentally Friendly Chemistry and Application of the Ministry of Education College of Chemistry, Xiangtan University, Xiangtan 411105, China
    More by Lulu Du
    • , 
  • Huajie Chen
    Huajie Chen
    Key Laboratory of Environmentally Friendly Chemistry and Application of the Ministry of Education College of Chemistry, Xiangtan University, Xiangtan 411105, China
    More by Huajie Chen
    Orcidhttp://orcid.org/0000-0003-0366-8826
    • , 
  • Ping Gong*
    Ping Gong
    Guangdong Key Laboratory of Nanomedicine, CAS-HK Joint Lab of Biomaterials, Shenzhen Engineering Laboratory of Nanomedicine and Nanoformulations, CAS Key Laboratory of Health Informatics, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China
    Dongguan Key Laboratory of Drug Design and Formulation Technology, Key Laboratory for Nanomedicine, Guangdong Medical University, Dongguan 523808, China
    *E-mail: [email protected]
    More by Ping Gong
    • , 
  • Pengfei Zhang*
    Pengfei Zhang
    Guangdong Key Laboratory of Nanomedicine, CAS-HK Joint Lab of Biomaterials, Shenzhen Engineering Laboratory of Nanomedicine and Nanoformulations, CAS Key Laboratory of Health Informatics, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China
    Department of Chemistry, Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction and Institute for Advanced Study, The Hong Kong University of Science and Technology (HKUST), Clear Water Bay, Kowloon, Hong Kong, China
    HKUST Shenzhen Research Institute, No. 9 Yuexing First Road, Nanshan, Shenzhen 518057, China
    *E-mail: [email protected]
    More by Pengfei Zhang
    Orcidhttp://orcid.org/0000-0003-0390-3806
    • , 
  • Lintao Cai*
    Lintao Cai
    Guangdong Key Laboratory of Nanomedicine, CAS-HK Joint Lab of Biomaterials, Shenzhen Engineering Laboratory of Nanomedicine and Nanoformulations, CAS Key Laboratory of Health Informatics, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China
    Zhuhai Institute of Advanced Technology Chinese Academy of Sciences, Zhuhai 519000, China
    *E-mail: [email protected]
    More by Lintao Cai
    Orcidhttp://orcid.org/0000-0002-2461-6390
    • , and 
  • Ben Zhong Tang*
    Ben Zhong Tang
    Department of Chemistry, Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction and Institute for Advanced Study, The Hong Kong University of Science and Technology (HKUST), Clear Water Bay, Kowloon, Hong Kong, China
    HKUST Shenzhen Research Institute, No. 9 Yuexing First Road, Nanshan, Shenzhen 518057, China
    *E-mail: [email protected]
    More by Ben Zhong Tang
    Orcidhttp://orcid.org/0000-0002-0293-964X
Cite this: ACS Nano 2020, 14, 9, 11452–11462
Publication Date (Web):August 21, 2020
https://doi.org/10.1021/acsnano.0c03824
Copyright © 2020 American Chemical Society
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Abstract

Abstract Image

Nature has always inspired robotic designs and concepts. It is conceivable that biomimic nanorobots will soon play a prominent role in medicine. The “Terminator” in the science fiction film is a cybernetic organism with living tissue over a metal endoskeleton, which inspired us to develop natural-killer-cell-mimic nanorobots with aggregation-induced emission (AIE) characteristics ([email protected]) by coating a natural kill cell membrane on an AIE-active polymeric endoskeleton, PBPTV, a highly bright NIR-II AIE-active conjugated polymer. Owing to the AIE and soft-matter characteristics of PBPTV, as-prepared [email protected] maintained a superior NIR-II brightness (quantum yield ∼7.9% in water) and good biocompatibility. Besides, they can serve as a tight junction (TJ) modulator to trigger an intracellular signaling cascade, causing TJ disruption and actin cytoskeleton reorganization to form an intercellular “green channel” to help them to cross the blood–brain barrier (BBB) silently. Furthermore, they can initiatively accumulate in glioblastoma cells in the complex brain matrix for high-contrast and through-skull tumor imaging. The tumor growth was also greatly inhibited by these [email protected] under the NIR light illumination. As far as we know, the quantum yield of PBPTV is the highest among the existing NIR-II luminescent conjugated polymers. Besides, the NK-cell biomimetic nanorobots showed great potential for BBB-crossing active delivery.

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The Supporting Information is available free of charge at https://pubs.acs.org/doi/10.1021/acsnano.0c03824.

  • Characterization of [email protected] and AIEdots; biocompatibility of [email protected] and AIEdots; in vitro and in vivo BBB crossing efficiency of [email protected]; NIR-II flow cytometry for study of cellular targeting ability of [email protected] to U-87 MG cells; NIR-II fluorescence imaging results of mouse brain; biodistribution and pharmacokinetics of [email protected]; in vitro photothermal therapy evaluation; experiment for assessing the depth of 808 nm laser penetrating the skull; experiment for assessing the skull scatter of 808 nm light; biological toxicity of [email protected]; experiment for assessing that NK-cell-mimic AIE system (PDF)

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Electronic Supporting Information files are available without a subscription to ACS Web Editions. The American Chemical Society holds a copyright ownership interest in any copyrightable Supporting Information. Files available from the ACS website may be downloaded for personal use only. Users are not otherwise permitted to reproduce, republish, redistribute, or sell any Supporting Information from the ACS website, either in whole or in part, in either machine-readable form or any other form without permission from the American Chemical Society. For permission to reproduce, republish and redistribute this material, requesters must process their own requests via the RightsLink permission system. Information about how to use the RightsLink permission system can be found at http://pubs.acs.org/page/copyright/permissions.html.

Cited By

This article is cited by 4 publications.

  1. Ping Gong, Yifan Wang, Pengfei Zhang, Zhaogang Yang, Weiye Deng, Zhihong Sun, Mingming Yang, Xuefeng Li, Gongcheng Ma, Guanjun Deng, Shiyan Dong, Lintao Cai, Wen Jiang. Immunocyte Membrane-Coated Nanoparticles for Cancer Immunotherapy. Cancers 2021, 13 (1) , 77. https://doi.org/10.3390/cancers13010077
  2. Nidhi Gupta, Yang‐Hsiang Chan, Sampa Saha, Ming‐Ho Liu. Near‐Infrared‐II Semiconducting Polymer Dots for Deep‐tissue Fluorescence Imaging. Chemistry – An Asian Journal 2020, 44 https://doi.org/10.1002/asia.202001348
  3. Miaomiao Kang, Zhijun Zhang, Nan Song, Meng Li, Panpan Sun, Xiaohui Chen, Dong Wang, Ben Zhong Tang. Aggregation‐enhanced theranostics: AIE sparkles in biomedical field. Aggregate 2020, 1 (1) , 80-106. https://doi.org/10.1002/agt2.7
  4. Masayuki Gon, Junko Wakabayashi, Masashi Nakamura, Kazuo Tanaka, Yoshiki Chujo. Preparation of Near‐Infrared Emissive π‐Conjugated Polymer Films Based on Boron‐Fused Azobenzene Complexes with Perpendicularly Protruded Aryl Substituents. Macromolecular Rapid Communications 2020, 4 , 2000566. https://doi.org/10.1002/marc.202000566

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