Biomimetic Surface-Enhanced Raman Scattering Nanoparticles with Improved Dispersibility, Signal Brightness, and Tumor Targeting FunctionsClick to copy article linkArticle link copied!
- Indrajit SrivastavaIndrajit SrivastavaDepartment of Bioengineering and Department of Electrical and Computer Engineering, University of Illinois at Urbana−Champaign, Urbana, Illinois 61801, United StatesMore by Indrajit Srivastava
- Ruiyang XueRuiyang XueDepartment of Materials Science and Engineering, University of Illinois at Urbana−Champaign, Urbana, Illinois 61801, United StatesMore by Ruiyang Xue
- Jamie JonesJamie JonesDepartment of Bioengineering, University of Illinois at Urbana−Champaign, Urbana, Illinois 61801, United StatesMore by Jamie Jones
- Hyunjoon RheeHyunjoon RheeDepartment of Bioengineering, University of Illinois at Urbana−Champaign, Urbana, Illinois 61801, United StatesMore by Hyunjoon Rhee
- Kristen FlattKristen FlattMaterials Research Laboratories Central Research Facilities, University of Illinois at Urbana−Champaign, Urbana, Illinois 61801, United StatesMore by Kristen Flatt
- Viktor Gruev*Viktor Gruev*Email: [email protected]Department of Electrical and Computer Engineering and Carle Illinois College of Medicine, University of Illinois at Urbana−Champaign, Urbana, Illinois 61801, United StatesMore by Viktor Gruev
- Shuming Nie*Shuming Nie*Email: [email protected]Department of Bioengineering, Department of Electrical and Computer Engineering, Department of Materials Science and Engineering, Department of Chemistry and Carle Illinois College of Medicine, University of Illinois at Urbana−Champaign, Urbana, Illinois 61801, United StatesMore by Shuming Nie
Abstract
The development of biocompatible and nontoxic surface-enhanced Raman scattering (SERS) nanoparticles is of considerable current interest because of their attractive biomedical applications such as ultrasensitive in vitro diagnostics, in vivo tumor imaging, and spectroscopy-guided cancer surgery. However, current SERS nanoparticles are prepared and stored in aqueous solution, have limited stability and dispersibility, and are not suitable for lyophilization and storage by freeze-drying or other means. Here, we report a simple but robust method to coat colloidal SERS nanoparticles by naturally derived biomimetic red blood cell membranes (RBCM), leading to a dramatic improvement in stability and dispersibility under freeze–thawing, lyophilization, heating, and physiological conditions. The results demonstrate that the lyophilized SERS nanoparticles in the solid form can be readily dissolved and dispersed in physiological buffer solutions. A surprising finding is that the RBCM-coated SERS particles are considerably brighter (by as much as 5-fold) than PEGylated SERS particles under similar experimental conditions. This additional enhancement is believed to arise from the hydrophobic nature of RBCM’s hydrocarbon chains, which is known to reduce electronic dampening and boost electromagnetic field enhancement. A further advantage in using biomimetic membrane coatings is that the bilayer membrane structure allows nonvalent insertion of molecular ligands for tumor targeting. In particular, we show that cyclic-RGD, a tumor-targeting peptide, can be efficiently inserted into the membrane coatings of SERS nanoparticles for targeting the ανβ3 integrin receptors expressed on cancer cells. Thus, biomimetic RBCMs provide major advantages over traditional polyethylene glycols for preparing SERS nanoparticles with improved dispersibility, higher signal intensity, and more efficient biofunctionalization.
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