Enhanced Nanobubble Formation: Gold Nanoparticle Conjugation to Qβ Virus-like Particles
- Perouza ParsamianPerouza ParsamianDepartment of Chemistry and Biochemistry, University of Texas at Dallas, 800 West Campbell Road, Richardson, Texas 75080, United StatesMore by Perouza Parsamian
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- Yaning LiuYaning LiuDepartment of Mechanical Engineering, University of Texas at Dallas, 800 West Campbell Road, Richardson, Texas 75080, United StatesMore by Yaning Liu
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- Chen XieChen XieDepartment of Mechanical Engineering, University of Texas at Dallas, 800 West Campbell Road, Richardson, Texas 75080, United StatesMore by Chen Xie
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- Zhuo ChenZhuo ChenDepartment of Chemistry and Biochemistry, University of Texas at Dallas, 800 West Campbell Road, Richardson, Texas 75080, United StatesMore by Zhuo Chen
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- Peiyuan KangPeiyuan KangDepartment of Mechanical Engineering, University of Texas at Dallas, 800 West Campbell Road, Richardson, Texas 75080, United StatesMore by Peiyuan Kang
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- Yalini H. WijesundaraYalini H. WijesundaraDepartment of Chemistry and Biochemistry, University of Texas at Dallas, 800 West Campbell Road, Richardson, Texas 75080, United StatesMore by Yalini H. Wijesundara
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- Noora M. Al-KharjiNoora M. Al-KharjiDepartment of Chemistry and Biochemistry, University of Texas at Dallas, 800 West Campbell Road, Richardson, Texas 75080, United StatesMore by Noora M. Al-Kharji
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- Ryanne Nicole EhrmanRyanne Nicole EhrmanDepartment of Chemistry and Biochemistry, University of Texas at Dallas, 800 West Campbell Road, Richardson, Texas 75080, United StatesMore by Ryanne Nicole Ehrman
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- Orikeda TrashiOrikeda TrashiDepartment of Chemistry and Biochemistry, University of Texas at Dallas, 800 West Campbell Road, Richardson, Texas 75080, United StatesMore by Orikeda Trashi
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- Jaona RandrianalisoaJaona RandrianalisoaInstitut de Thermique, Mécanique, Matériaux − ITheMM EA 7548 Université de Reims Champagne-Ardenne, Campus Moulin de la Housse, F-51687 Reims, FranceMore by Jaona Randrianalisoa
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- Xiangyu ZhuXiangyu ZhuDepartment of Materials Science and Engineering, University of Texas at Dallas, 800 West Campbell Road, Richardson, Texas 75080, United StatesMore by Xiangyu Zhu
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- Matthew D’SouzaMatthew D’SouzaDepartment of Chemistry and Biochemistry, University of Texas at Dallas, 800 West Campbell Road, Richardson, Texas 75080, United StatesMore by Matthew D’Souza
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- Lucas Anderson WilsonLucas Anderson WilsonDepartment of Chemistry and Biochemistry, University of Texas at Dallas, 800 West Campbell Road, Richardson, Texas 75080, United StatesMore by Lucas Anderson Wilson
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- Moon J. KimMoon J. KimDepartment of Materials Science and Engineering, University of Texas at Dallas, 800 West Campbell Road, Richardson, Texas 75080, United StatesMore by Moon J. Kim
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- Zhenpeng Qin*Zhenpeng Qin*Email: [email protected]Department of Mechanical Engineering, University of Texas at Dallas, 800 West Campbell Road, Richardson, Texas 75080, United StatesMore by Zhenpeng Qin
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- Jeremiah J. Gassensmith*Jeremiah J. Gassensmith*Email: [email protected]Department of Chemistry and Biochemistry and Department of Biomedical Engineering, University of Texas at Dallas, 800 West Campbell Road, Richardson, Texas 75080, United StatesMore by Jeremiah J. Gassensmith
Abstract
Plasmonic gold nanostructures are a prevalent tool in modern hypersensitive analytical techniques such as photoablation, bioimaging, and biosensing. Recent studies have shown that gold nanostructures generate transient nanobubbles through localized heating and have been found in various biomedical applications. However, the current method of plasmonic nanoparticle cavitation events has several disadvantages, specifically including small metal nanostructures (≤10 nm) which lack size control, tuneability, and tissue localization by use of ultrashort pulses (ns, ps) and high-energy lasers which can result in tissue and cellular damage. This research investigates a method to immobilize sub-10 nm AuNPs (3.5 and 5 nm) onto a chemically modified thiol-rich surface of Qβ virus-like particles. These findings demonstrate that the multivalent display of sub-10 nm gold nanoparticles (AuNPs) caused a profound and disproportionate increase in photocavitation by upward of 5–7-fold and significantly lowered the laser fluency by 4-fold when compared to individual sub-10 nm AuNPs. Furthermore, computational modeling showed that the cooling time of QβAuNP scaffolds is significantly extended than that of individual AuNPs, proving greater control of laser fluency and nanobubble generation as seen in the experimental data. Ultimately, these findings showed how QβAuNP composites are more effective at nanobubble generation than current methods of plasmonic nanoparticle cavitation.
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