ACS Publications. Most Trusted. Most Cited. Most Read
Bioengineered Nanomaterials for siRNA Therapy of Chemoresistant Cancers

OR SEARCH CITATIONS

My Activity
Publications

Figure 1Loading Img
Download Hi-Res ImageDownload to MS-PowerPointCite This:ACS Nano 2024, 18, 51, 34425-34463
    Review

    Bioengineered Nanomaterials for siRNA Therapy of Chemoresistant Cancers
    Click to copy article linkArticle link copied!

    • Mehdi Sanati
      Mehdi Sanati
      Department of Pharmacology and Toxicology, Faculty of Pharmacy, Birjand University of Medical Sciences, Birjand 97178, Iran
      More by Mehdi Sanati
    • Christian G. Figueroa-Espada
      Christian G. Figueroa-Espada
      Department of Bioengineering, University of Pennsylvania, 210 South 33rd Street, Philadelphia, Pennsylvania 19104, United States
      More by Christian G. Figueroa-Espada
      Orcidhttps://orcid.org/0000-0003-2700-7678
    • Emily L. Han
      Emily L. Han
      Department of Bioengineering, University of Pennsylvania, 210 South 33rd Street, Philadelphia, Pennsylvania 19104, United States
      More by Emily L. Han
      Orcidhttps://orcid.org/0009-0008-6276-7502
    • Michael J. Mitchell*
      Michael J. Mitchell
      Department of Bioengineering, University of Pennsylvania, 210 South 33rd Street, Philadelphia, Pennsylvania 19104, United States
      Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States
      Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States
      Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States
      Institute for Regenerative Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States
      Penn Institute for RNA Innovation, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States
      Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States
      *Phone: (215) 898-0882, E-mail: [email protected]
      More by Michael J. Mitchell
      Orcidhttps://orcid.org/0000-0002-3628-2244
    • Saber Amin Yavari*
      Saber Amin Yavari
      Department of Orthopedics, University Medical Center Utrecht, 3584 Utrecht, The Netherlands
      Regenerative Medicine Center Utrecht, University Medical Center Utrecht, 3584 Utrecht, The Netherlands
      *Phone: (644) 55-3854, E-mail: [email protected]
      More by Saber Amin Yavari
      Orcidhttps://orcid.org/0000-0003-1677-5751
    Other Access Options

    ACS Nano

    Cite this: ACS Nano 2024, 18, 51, 34425–34463
    Click to copy citationCitation copied!
    https://doi.org/10.1021/acsnano.4c11259
    Published December 12, 2024
    Copyright © 2024 American Chemical Society
    Request reuse permissions

    Abstract

    Click to copy section linkSection link copied!
    Abstract Image

    Chemoresistance remains a long-standing challenge after cancer treatment. Over the last two decades, RNA interference (RNAi) has emerged as a gene therapy modality to sensitize cancer cells to chemotherapy. However, the use of RNAi, specifically small-interfering RNA (siRNA), is hindered by biological barriers that limit its intracellular delivery. Nanoparticles can overcome these barriers by protecting siRNA in physiological environments and facilitating its delivery to cancer cells. In this review, we discuss the development of nanomaterials for siRNA delivery in cancer therapy, current challenges, and future perspectives for their implementation to overcome cancer chemoresistance.

    Copyright © 2024 American Chemical Society

    Subjects

    what are subjects

    Keywords

    what are keywords

    Read this article

    To access this article, please review the available access options below.

    Get instant access

    Purchase Access

    Read this article for 48 hours. Check out below using your ACS ID or as a guest.

    Recommended

    Access through Your Institution

    You may have access to this article through your institution.

    Your institution does not have access to this content. Add or change your institution or let them know you’d like them to include access.

    Cited By

    Click to copy section linkSection link copied!

    This article has not yet been cited by other publications.

    Download PDF
    Go to ACS Nano
    Get e-Alerts
    Get e-Alerts

    ACS Nano

    Cite this: ACS Nano 2024, 18, 51, 34425–34463
    Click to copy citationCitation copied!
    https://doi.org/10.1021/acsnano.4c11259
    Published December 12, 2024
    Copyright © 2024 American Chemical Society
    Request reuse permissions

    Article Views

    761

    Altmetric

    -

    Citations

    -
    Learn about these metrics

    Article Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.

    Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.

    The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated.