Flexible Electrode Arrays Based on a Wide Bandgap Semiconductors for Chronic Implantable Multiplexed Sensing and Heart PacemakersClick to copy article linkArticle link copied!
- Thanh An TruongThanh An TruongSchool of Mechanical and Manufacturing Engineering, University of New South Wales, Sydney, New South Wales 2052, AustraliaMore by Thanh An Truong
- Xinghao HuangXinghao HuangDepartment of Aerospace and Mechanical Engineering, University of Southern California, Los Angeles, California 90089, United StatesMore by Xinghao Huang
- Matthew BartonMatthew BartonSchool of Nursing & Midwifery, Griffith University, Gold Coast Campus, Queensland 4215, AustraliaInstitute for Biomedicine and Glycomics, Griffith University, Gold Coast Campus, Queensland 4215, AustraliaClem Jones Centre for Neurobiology and Stem Cell Research, Griffith University, Nathan, Queensland 4111, AustraliaMore by Matthew Barton
- Aditya AshokAditya AshokSchool of Mechanical and Manufacturing Engineering, University of New South Wales, Sydney, New South Wales 2052, AustraliaMore by Aditya Ashok
- Amr Al AbedAmr Al AbedGraduate School of Biomedical Engineering, University of New South Wales, Sydney, New South Wales 2052, AustraliaMore by Amr Al Abed
- Reem AlmasriReem AlmasriGraduate School of Biomedical Engineering, University of New South Wales, Sydney, New South Wales 2052, AustraliaMore by Reem Almasri
- Mohit N. ShivdasanicMohit N. ShivdasanicGraduate School of Biomedical Engineering, University of New South Wales, Sydney, New South Wales 2052, AustraliaMore by Mohit N. Shivdasanic
- Ronak ReshamwalaRonak ReshamwalaInstitute for Biomedicine and Glycomics, Griffith University, Gold Coast Campus, Queensland 4215, AustraliaClem Jones Centre for Neurobiology and Stem Cell Research, Griffith University, Nathan, Queensland 4111, AustraliaMore by Ronak Reshamwala
- Joshua InglesJoshua InglesInstitute for Biomedicine and Glycomics, Griffith University, Gold Coast Campus, Queensland 4215, AustraliaClem Jones Centre for Neurobiology and Stem Cell Research, Griffith University, Nathan, Queensland 4111, AustraliaMore by Joshua Ingles
- Mai Thanh ThaiMai Thanh ThaiGraduate School of Biomedical Engineering, University of New South Wales, Sydney, New South Wales 2052, AustraliaCollege of Engineering and Computer Science and VinUni-Illinois Smart Health Center, Vin University, Hanoi 100000, VietnamMore by Mai Thanh Thai
- Chi Cong NguyenChi Cong NguyenGraduate School of Biomedical Engineering, University of New South Wales, Sydney, New South Wales 2052, AustraliaMore by Chi Cong Nguyen
- Sinuo ZhaoSinuo ZhaoSchool of Mechanical and Manufacturing Engineering, University of New South Wales, Sydney, New South Wales 2052, AustraliaMore by Sinuo Zhao
- Xiuwen ZhangXiuwen ZhangSchool of Chemical Engineering, University of New South Wales, Sydney, New South Wales 2052, AustraliaMore by Xiuwen Zhang
- Zi GuZi GuSchool of Chemical Engineering, University of New South Wales, Sydney, New South Wales 2052, AustraliaAustralian Centre for Nanomedicine (ACN), University of New South Wales, Sydney, New South Wales 2052, AustraliaUNSW RNA Institute, University of New South Wales, Sydney, New South Wales 2052, AustraliaMore by Zi Gu
- Arya VasanthArya VasanthSchool of Mechanical and Manufacturing Engineering, University of New South Wales, Sydney, New South Wales 2052, AustraliaMore by Arya Vasanth
- Shuhua PengShuhua PengSchool of Mechanical and Manufacturing Engineering, University of New South Wales, Sydney, New South Wales 2052, AustraliaMore by Shuhua Peng
- Tuan-Khoa NguyenTuan-Khoa NguyenQueensland Micro and Nanotechnology Centre, Griffith University, Nathan Campus, Queensland 4111, AustraliaMore by Tuan-Khoa Nguyen
- Nho DoNho DoClem Jones Centre for Neurobiology and Stem Cell Research, Griffith University, Nathan, Queensland 4111, AustraliaTyree Foundation Institute of Health Engineering, University of New South Wales, Sydney, New South Wales 2052, AustraliaMore by Nho Do
- Nam-Trung NguyenNam-Trung NguyenQueensland Micro and Nanotechnology Centre, Griffith University, Nathan Campus, Queensland 4111, AustraliaMore by Nam-Trung Nguyen
- Hangbo ZhaoHangbo ZhaoDepartment of Aerospace and Mechanical Engineering, University of Southern California, Los Angeles, California 90089, United StatesAlfred E. Mann Department of Biomedical Engineering, University of Southern California, Los Angeles, California 90089, United StatesMore by Hangbo Zhao
- Hoang-Phuong Phan*Hoang-Phuong Phan*Email: [email protected]School of Mechanical and Manufacturing Engineering, University of New South Wales, Sydney, New South Wales 2052, AustraliaTyree Foundation Institute of Health Engineering, University of New South Wales, Sydney, New South Wales 2052, AustraliaMore by Hoang-Phuong Phan
Abstract
Implantable systems with chronic stability, high sensing performance, and extensive spatial-temporal resolution are a growing focus for monitoring and treating several diseases such as epilepsy, Parkinson’s disease, chronic pain, and cardiac arrhythmias. These systems demand exceptional bendability, scalable size, durable electrode materials, and well-encapsulated metal interconnects. However, existing chronic implantable bioelectronic systems largely rely on materials prone to corrosion in biofluids, such as silicon nanomembranes or metals. This study introduces a multielectrode array featuring a wide bandgap (WBG) material as electrodes, demonstrating its suitability for chronic implantable applications. Our devices exhibit excellent flexibility and longevity, taking advantage of the low bending stiffness and chemical inertness in WBG nanomembranes and multimodalities for physical health monitoring, including temperature, strain, and impedance sensing. Our top-down manufacturing process enables the formation of distributed electrode arrays that can be seamlessly integrated onto the curvilinear surfaces of skins. As proof of concept for chronic cardiac pacing applications, we demonstrate the effective pacing functionality of our devices on rabbit hearts through a set of ex vivo experiments. The engineering approach proposed in this study overcomes the drawbacks of prior WBG material fabrication techniques, resulting in an implantable system with high bendability, effective pacing, and high-performance sensing.
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