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Two-Dimensional Graphene Augments Nanosonosensitized Sonocatalytic Tumor Eradication

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† Department of Ultrasound in Medicine, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai 200072, People’s Republic of China
‡ Department of Radiology, Fudan University Shanghai Cancer Center, Shanghai 200032, People’s Republic of China
§ Department of Ultrasound, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, People’s Republic of China
∥ State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, People’s Republic of China
*E-mail: [email protected] (S. Zhang).
*E-mail: [email protected] (R. Wu).
*E-mail: [email protected] (Y. Chen).
Cite this: ACS Nano 2017, 11, 9, 9467–9480
Publication Date (Web):August 22, 2017
https://doi.org/10.1021/acsnano.7b05215
Copyright © 2017 American Chemical Society
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Abstract

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Ultrasound (US) can activate sonosensitizers for sonodynamic therapy (SDT), but the low activation efficiency and therapeutic outcome significantly hinder its further clinical translation. Inspired by the principles of semiconductor physics and photocatalysis chemistry, we herein report on augmenting the sonocatalytic efficiency of semiconductor TiO2-based nanosonosensitizers for highly efficient SDT by the integration of two-dimensional (2D) ultrathin graphene with TiO2 nanosonosensitizers. The high electroconductivity of graphene facilitates the separation of the electron (e–) and hole (h+) pairs from the energy band of TiO2 and avoids their recombination upon external US irradiation; thus it significantly augments the therapeutic efficiency of TiO2 nanosonosensitizers for SDT against tumors. By further MnOx functionalization, these 2D composite nanosonosensitizers achieved tumor microenvironment-sensitive (mild acidity) T1-weighted magnetic resonance imaging of tumors for therapeutic guidance and monitoring. The high photothermal-conversion capability of graphene also synergistically enhanced the SDT efficiency, achieving the complete eradication of a tumor without reoccurrence. This work provides a paradigm for augmenting semiconductor TiO2-based sonocatalytic therapeutic nanomedicine by learning the physiochemical principles from traditional photocatalysis, which also demonstrates a highly efficient noninvasive and safe therapeutic modality for tumor eradication by the nanosonosensitized sonocatalytic process.

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