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Copper Silicate Hollow Microspheres-Incorporated Scaffolds for Chemo-Photothermal Therapy of Melanoma and Tissue Healing

  • Qingqing Yu
    Qingqing Yu
    State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Dingxi Road, Shanghai 200050, People’s Republic of China
    University of Chinese Academy of Sciences, 19 Yuquan Road, Beijing 100049, People’s Republic of China
    More by Qingqing Yu
    • , 
  • Yiming Han
    Yiming Han
    Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, 500 Dongchuan Road, Shanghai 200241, People’s Republic of China
    More by Yiming Han
    • , 
  • Xiaocheng Wang
    Xiaocheng Wang
    State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Dingxi Road, Shanghai 200050, People’s Republic of China
    University of Chinese Academy of Sciences, 19 Yuquan Road, Beijing 100049, People’s Republic of China
    More by Xiaocheng Wang
    • , 
  • Chen Qin
    Chen Qin
    State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Dingxi Road, Shanghai 200050, People’s Republic of China
    University of Chinese Academy of Sciences, 19 Yuquan Road, Beijing 100049, People’s Republic of China
    More by Chen Qin
    • , 
  • Dong Zhai
    Dong Zhai
    State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Dingxi Road, Shanghai 200050, People’s Republic of China
    More by Dong Zhai
    • , 
  • Zhengfang Yi*
    Zhengfang Yi
    Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, 500 Dongchuan Road, Shanghai 200241, People’s Republic of China
    *E-mail: [email protected]. (Z. F. Yi).
    More by Zhengfang Yi
    • , 
  • Jiang Chang
    Jiang Chang
    State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Dingxi Road, Shanghai 200050, People’s Republic of China
    More by Jiang Chang
    Orcidhttp://orcid.org/0000-0003-1462-6541
    • , 
  • Yin Xiao
    Yin Xiao
    The Institute of Health and Biomedical Innovation, Queensland University of Technology, 80 Musk Avenue, Queensland 4059, Australia
    More by Yin Xiao
    • , and 
  • Chengtie Wu*
    Chengtie Wu
    State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Dingxi Road, Shanghai 200050, People’s Republic of China
    *E-mail: [email protected]. (C. T. Wu).
    More by Chengtie Wu
    Orcidhttp://orcid.org/0000-0002-5986-591X
Cite this: ACS Nano 2018, 12, 3, 2695–2707
Publication Date (Web):March 8, 2018
https://doi.org/10.1021/acsnano.7b08928
Copyright © 2018 American Chemical Society
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Abstract

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The treatment of melanoma requires complete removal of tumor cells and simultaneous tissue regeneration of tumor-initiated cutaneous defects. Herein, copper silicate hollow microspheres (CSO HMSs)-incorporated bioactive scaffolds were designed for chemo-photothermal therapy of skin cancers and regeneration of skin tissue. CSO HMSs were synthesized with interior hollow and external nanoneedle microstructure, showing excellent drug-loading capacity and photothermal effects. With incorporation of drug-loaded CSO HMSs into the electrospun scaffolds, the composite scaffolds exhibited excellent photothermal effects and controlled NIR-triggered drug release, leading to distinctly synergistic chemo-photothermal therapy of skin cancer both in vitro and in vivo. Furthermore, such CSO HMSs-incorporated scaffolds could promote proliferation and attachment of normal skin cells and accelerate skin tissue healing in tumor-bearing and diabetic mice. Taken together, CSO HMSs-incorporated scaffolds may be used for complete eradication of the remaining tumor cells after surgery and simultaneous tissue healing, which offers an effective strategy for therapy and regeneration of tumor-initiated tissue defects.

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