Light-Activated Core–Shell Nanoparticles for Spatiotemporally Specific Treatment of Metastatic Triple-Negative Breast Cancer
- Qingshuo MengQingshuo MengState Key Laboratory of Drug Research and Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, ChinaUniversity of Chinese Academy of Sciences, Beijing 100049, ChinaMore by Qingshuo Meng,
- Jia MengJia MengState Key Laboratory of Drug Research and Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, ChinaUniversity of Chinese Academy of Sciences, Beijing 100049, ChinaMore by Jia Meng,
- Wei RanWei RanState Key Laboratory of Drug Research and Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, ChinaUniversity of Chinese Academy of Sciences, Beijing 100049, ChinaMore by Wei Ran,
- Junyang WangJunyang WangState Key Laboratory of Drug Research and Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, ChinaJilin University, Changchun, Jilin 130012, ChinaMore by Junyang Wang,
- Yihui ZhaiYihui ZhaiState Key Laboratory of Drug Research and Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, ChinaUniversity of Chinese Academy of Sciences, Beijing 100049, ChinaMore by Yihui Zhai,
- Pengcheng Zhang*Pengcheng Zhang*E-mail: [email protected]State Key Laboratory of Drug Research and Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, ChinaMore by Pengcheng Zhang, and
- Yaping Li*Yaping Li*E-mail: [email protected]State Key Laboratory of Drug Research and Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, ChinaMore by Yaping Li
Abstract
Triple-negative breast cancer (TNBC) tumors are heterogeneous, with mesenchymal-like cells at their core and fast proliferating cells on the periphery. It is desirable and beneficial to treat TNBC cells of different phenotypes with the most appropriate drugs. Here, we report a 78 nm, chlorin e6-, docetaxel-, and anti-Twist siRNA-containing polymeric nanoparticle (CDTN) with spatiotemporally specific activity when irradiated by light. Under conditions mimicking superficial tumor tissue with sufficient light input, TNBC cells are mainly killed by the photodynamic therapy (PDT) function of CDTNs. In contrast, under conditions mimicking deep tumor tissue with weak light input, PDT potentiates chemotherapy (CT) and gene therapy (GT) by facilitating the endolysosomal escape of CDTNs. Compared with free drugs, CDTNs improve the intratumoral exposure of docetaxel and anti-Twist siRNA by 2.5- and 2-fold, respectively. When combined with laser irradiation applied at the time of maximal intratumoral accumulation, the CDTNs significantly inhibit the growth of primary tumors and their lung metastasis (both >80%) by killing the peripheral cells, mainly through PDT and prohibiting the growth and metastasis of deep cells through PDT as enhanced CT and GT. On the contrary, dual-modality nanomedicine lacking CT, GT, or PDT showed fast primary tumor growth, poor metastasis control, or both, respectively. This study reveals the spatiotemporally specific mechanism of CDTNs in treating metastatic TNBC and highlights the importance of combined therapy in treating TNBC.
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- Mauricio A. Medina, Goldie Oza, Ashutosh Sharma, L.G. Arriaga, José Manuel Hernández Hernández, Vincent M. Rotello, Jose Tapia Ramirez. Triple-Negative Breast Cancer: A Review of Conventional and Advanced Therapeutic Strategies. International Journal of Environmental Research and Public Health 2020, 17 (6) , 2078. https://doi.org/10.3390/ijerph17062078
- Chao He, Luodan Yu, Li Ding, Yu Chen, Yongqiang Hao. Self‐Assembled/Drug‐Composed Nanomedicine for Synergistic Photonic Hyperthermia and Targeted Therapy of Breast Cancer by Inhibiting ERK, AKT, and STAT3 Signaling Cascades. Advanced Functional Materials 2020, 2017 , 1908907. https://doi.org/10.1002/adfm.201908907
- Marco Cordani, Raffaele Strippoli, Álvaro Somoza. Nanomaterials as Inhibitors of Epithelial Mesenchymal Transition in Cancer Treatment. Cancers 2020, 12 (1) , 25. https://doi.org/10.3390/cancers12010025
- Cong Wang, Wenpei Fan, Zijian Zhang, Yu Wen, Li Xiong, Xiaoyuan Chen. Advanced Nanotechnology Leading the Way to Multimodal Imaging‐Guided Precision Surgical Therapy. Advanced Materials 2019, 31 (49) , 1904329. https://doi.org/10.1002/adma.201904329
- Shiwei Niu, Gareth R. Williams, Jianrong Wu, Junzi Wu, Xuejing Zhang, Xia Chen, Shude Li, Jianlin Jiao, Li-Min Zhu. A chitosan-based cascade-responsive drug delivery system for triple-negative breast cancer therapy. Journal of Nanobiotechnology 2019, 17 (1) https://doi.org/10.1186/s12951-019-0529-4
- Benjamin D White, Chengchen Duan, Helen E Townley. Nanoparticle Activation Methods in Cancer Treatment. Biomolecules 2019, 9 (5) , 202. https://doi.org/10.3390/biom9050202
- Kapil D. Patel, Rajendra K. Singh, Hae-Won Kim. Carbon-based nanomaterials as an emerging platform for theranostics. Materials Horizons 2019, 6 (3) , 434-469. https://doi.org/10.1039/C8MH00966J
- Enhui Zhang, Ronge Xing, Song Liu, Pengcheng Li. Current advances in development of new docetaxel formulations. Expert Opinion on Drug Delivery 2019, 16 (3) , 301-312. https://doi.org/10.1080/17425247.2019.1583644
- Mengru Wang, Wanhua Liu, Yanqiu Zhang, Meng Dang, Yunlei Zhang, Jun Tao, Kun Chen, Xin Peng, Zhaogang Teng. Intercellular adhesion molecule 1 antibody-mediated mesoporous drug delivery system for targeted treatment of triple-negative breast cancer. Journal of Colloid and Interface Science 2019, 538 , 630-637. https://doi.org/10.1016/j.jcis.2018.12.032
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- Xiaoqing Yi, Jun Dai, Yingyan Han, Min Xu, Xiaojin Zhang, Shijie Zhen, Zujin Zhao, Xiaoding Lou, Fan Xia. A high therapeutic efficacy of polymeric prodrug nano-assembly for a combination of photodynamic therapy and chemotherapy. Communications Biology 2018, 1 (1) https://doi.org/10.1038/s42003-018-0204-6
- Ya Wang, Xiaoyu Huang, Yunyun Tang, Jianhua Zou, Peng Wang, Yewei Zhang, Weili Si, Wei Huang, Xiaochen Dong. A light-induced nitric oxide controllable release nano-platform based on diketopyrrolopyrrole derivatives for pH-responsive photodynamic/photothermal synergistic cancer therapy. Chemical Science 2018, 9 (42) , 8103-8109. https://doi.org/10.1039/C8SC03386B
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- Zuozhong Liang, Zhiyuan Yang, Haitao Yuan, Chun Wang, Jing Qi, Kaiqiang Liu, Rui Cao, Haoquan Zheng. A [email protected]–organic framework nanocomposite for pH-triggered anticancer drug delivery. Dalton Transactions 2018, 47 (30) , 10223-10228. https://doi.org/10.1039/C8DT01789A