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Peptide-Driven Shape Control of Low-Dimensional DNA Nanostructures

  • Chan-Jin Kim
    Chan-Jin Kim
    Department of Chemistry and Nanoscience, Ewha Womans University, 52 Ewhayeodae-gil, Seodaemun-gu, Seoul 03760, Korea
    More by Chan-Jin Kim
    Orcidhttp://orcid.org/0000-0001-8365-1295
  • , 
  • Ji-eun Park
    Ji-eun Park
    Department of Chemistry and Nanoscience, Ewha Womans University, 52 Ewhayeodae-gil, Seodaemun-gu, Seoul 03760, Korea
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  • , 
  • Xiaole Hu
    Xiaole Hu
    Department of Chemistry and Nanoscience, Ewha Womans University, 52 Ewhayeodae-gil, Seodaemun-gu, Seoul 03760, Korea
    More by Xiaole Hu
  • , 
  • Shine K. Albert
    Shine K. Albert
    Department of Chemistry and Nanoscience, Ewha Womans University, 52 Ewhayeodae-gil, Seodaemun-gu, Seoul 03760, Korea
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  • , and 
  • So-Jung Park*
    So-Jung Park
    Department of Chemistry and Nanoscience, Ewha Womans University, 52 Ewhayeodae-gil, Seodaemun-gu, Seoul 03760, Korea
    *E-mail [email protected] (S.-J.P.).
    More by So-Jung Park
    Orcidhttp://orcid.org/0000-0002-6364-3754
Cite this: ACS Nano 2020, 14, 2, 2276–2284
Publication Date (Web):January 21, 2020
https://doi.org/10.1021/acsnano.9b09312
Copyright © 2020 American Chemical Society
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    Abstract

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    We report the rational design and fabrication of unusual low-dimensional DNA nanostructures through programmable and sequence-specific peptide interactions. Dual-bioactive block copolymers composed of DNA and amino acid-based polymers (DNA-b-poly(amino acid)) were synthesized by coupling oligonucleotides to phenylalanine (Phe)-based polymers. Unlike prototypical DNA block copolymers, which typically form simple spherical micelles, DNA-b-poly(amino acid) assemble into various low-dimensional structures such as nanofibers, ribbons, and sheets through controllable amino acid interactions. Moreover, DNA-b-poly(amino acid) assemblies can undergo protease-induced fiber-to-sheet shape transformations, where the morphology change is dictated by the type of enzymes and amino acid sequences. The peptide-based self-assembly reported here provides a programmable approach to fabricate dynamic DNA assemblies with diverse and unusual low-dimensional structures.

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    The Supporting Information is available free of charge at https://pubs.acs.org/doi/10.1021/acsnano.9b09312.

    • Materials and instrumentation, synthesis of N-acryloyl-Phe-OMe and N-acryloyl-Phe-Phe-OMe, synthesis of poly(Phe-OMe) and poly(Phe-Phe-OMe), synthesis of DNA1-b-poly(Phe-OMe) and DNA1-b-poly(Phe-Phe-OMe), determination of critical micelle concentration, circular dichroism analysis, synthesis of DNA functionalized gold nanoparticles, DNA dehybridization curves, HPLC chromatograms, NMR spectra, GPC data, DNA sequences, gel electrophoresis data, polarity index of various solvents used in this study, and additional TEM data (PDF)

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    This article is cited by 23 publications.

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