Repurposing Drugs and Synergistic Combinations as Potential Therapies for Inhibiting SARS-CoV-2 and Coronavirus ReplicationClick to copy article linkArticle link copied!
- Richard Boulon*Richard Boulon*Email: [email protected]Institut National de la Recherche Scientifique−Centre Armand-Frappier Santé Biotechnologie, 531 boulevard des Prairies, Laval, Québec H7V 1B7, CanadaMore by Richard Boulon
- Clément MazeaudClément MazeaudInstitut National de la Recherche Scientifique−Centre Armand-Frappier Santé Biotechnologie, 531 boulevard des Prairies, Laval, Québec H7V 1B7, CanadaMore by Clément Mazeaud
- Majid D. FarahaniMajid D. FarahaniInstitut National de la Recherche Scientifique−Centre Armand-Frappier Santé Biotechnologie, 531 boulevard des Prairies, Laval, Québec H7V 1B7, CanadaMore by Majid D. Farahani
- Mathilde BroquièreMathilde BroquièreInstitut National de la Recherche Scientifique−Centre Armand-Frappier Santé Biotechnologie, 531 boulevard des Prairies, Laval, Québec H7V 1B7, CanadaMore by Mathilde Broquière
- Mustapha IddirMustapha IddirInstitut National de la Recherche Scientifique−Centre Armand-Frappier Santé Biotechnologie, 531 boulevard des Prairies, Laval, Québec H7V 1B7, CanadaMore by Mustapha Iddir
- Tania CharpentierTania CharpentierInstitut National de la Recherche Scientifique−Centre Armand-Frappier Santé Biotechnologie, 531 boulevard des Prairies, Laval, Québec H7V 1B7, CanadaMore by Tania Charpentier
- Anaïs AntonAnaïs AntonInstitut National de la Recherche Scientifique−Centre Armand-Frappier Santé Biotechnologie, 531 boulevard des Prairies, Laval, Québec H7V 1B7, CanadaMore by Anaïs Anton
- Yann AyotteYann AyotteNMX Research and Solutions|Accelerating drug discovery, 500 boulevard Cartier Ouest, Laval, Quebec H7V 5B7, CanadaMore by Yann Ayotte
- Simon WooSimon WooInstitut National de la Recherche Scientifique−Centre Armand-Frappier Santé Biotechnologie, 531 boulevard des Prairies, Laval, Québec H7V 1B7, CanadaNMX Research and Solutions|Accelerating drug discovery, 500 boulevard Cartier Ouest, Laval, Quebec H7V 5B7, CanadaMore by Simon Woo
- Alain Lamarre*Alain Lamarre*Email: [email protected]Institut National de la Recherche Scientifique−Centre Armand-Frappier Santé Biotechnologie, 531 boulevard des Prairies, Laval, Québec H7V 1B7, CanadaMore by Alain Lamarre
- Laurent Chatel-ChaixLaurent Chatel-ChaixInstitut National de la Recherche Scientifique−Centre Armand-Frappier Santé Biotechnologie, 531 boulevard des Prairies, Laval, Québec H7V 1B7, CanadaMore by Laurent Chatel-Chaix
- Steven R. LaPlante*Steven R. LaPlante*Email: [email protected]Institut National de la Recherche Scientifique−Centre Armand-Frappier Santé Biotechnologie, 531 boulevard des Prairies, Laval, Québec H7V 1B7, CanadaMore by Steven R. LaPlante
Abstract

Drug repurposing can serve an important role in rapidly discovering medicament options for emerging microbial pandemics. In this study, a pragmatic approach is demonstrated for screening and testing drug combinations as potential broad-spectrum therapies against SARS-CoV-2 and other betacoronaviruses. Rapid cell-based phenotypic small molecule screens were executed using related common-cold-causing HCoV-OC43 betacoronavirus to identify replication inhibitors from a library of drugs approved by regulatory agencies for other indications. Given the best inhibitors, an expedient checkerboard strategy then served to identify synergistic drug combinations. These combinations were then validated using more challenging assays involving SARS-CoV-2 and variants. Promising drug combinations against multiple viral variants were discovered and involved Tilorone with Nelfinavir or Molnupiravir.
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This article is cited by 1 publications.
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, 1205. https://doi.org/10.3390/nu17071205
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