Silane Grafted Biosourced Melanin: A Sustainable Approach for Nanobiosensing ApplicationsClick to copy article linkArticle link copied!
- Mariana CaldasMariana Caldas3B’s Research Group, I3Bs − Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, Parque de Ciência e Tecnologia, Zona Industrial da Gandra, Barco, 4805-017 Guimarães, PortugalMore by Mariana Caldas
- Miguel NevesMiguel Neves3B’s Research Group, I3Bs − Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, Parque de Ciência e Tecnologia, Zona Industrial da Gandra, Barco, 4805-017 Guimarães, PortugalMore by Miguel Neves
- Albina R. FrancoAlbina R. Franco3B’s Research Group, I3Bs − Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, Parque de Ciência e Tecnologia, Zona Industrial da Gandra, Barco, 4805-017 Guimarães, PortugalMore by Albina R. Franco
- Mrinal BhattacharyaMrinal BhattacharyaDepartment of Biosystems Engineering, University of Minnesota, St. Paul, Minnesota 55108, United StatesMore by Mrinal Bhattacharya
- Rui L. ReisRui L. Reis3B’s Research Group, I3Bs − Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, Parque de Ciência e Tecnologia, Zona Industrial da Gandra, Barco, 4805-017 Guimarães, PortugalMore by Rui L. Reis
- Vitor M. Correlo*Vitor M. Correlo*Telephone: +351-253-51093. E-mail: [email protected]3B’s Research Group, I3Bs − Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, Parque de Ciência e Tecnologia, Zona Industrial da Gandra, Barco, 4805-017 Guimarães, PortugalMore by Vitor M. Correlo
Abstract
Nanotechnology has revolutionized areas of biotechnology owing to its multidiversified applications, improved sensitivity, surface size, and cost. In the past years, some issues have arisen regarding the impact of nanomaterials on the environment and human health. In this regard, there is a growing interest in identifying natural and sustainable nanostructured biomaterials as an alternative to toxic petrochemical derived materials. The most commonly used materials in nanobiotechnology applications possess inherent limitations regarding biocompatibility, which leads to foreign-body response at the implantation site, causing a rejection of the implant. In parallel, the recovery of byproducts from other industries and their transformation into valuable resources have been key factors in the circular economy. Given that, there is urgency to move toward sustainable research and green nanotechnologies with an undeniable biocompatibility. Herein, we propose a design based on natural melanin nanoparticles (MNPs) obtained from the ink sacs of Sepia officinalis, a waste product from the food industry, grafted with silane (MNPs GPTMS) for biomedical applications. The design, characterization of both physical and chemical properties, and biological properties of the MNPs GPTMS are reported. The silane, (3-glycidyloxypropyl)trimethoxysilane, allows facile functionalization of different bioreceptors onto the surface of MNPs GPTMS, herein demonstrated with antibodies and an enzyme. Cellular viability studies confirmed the cytocompatibility of MNPs GPTMS and hemocompatibility of 50 μg/mL. The engineered MNPs GPTMS provide a powerful, sustainable, and biocompatible biomaterial-based tool for specific bioreceptor targeting molecules that can be used in diverse biomedical field applications such as nanobiosensing.
Cited By
This article is cited by 2 publications.
- Mariana Caldas, Ana I. Barbosa, Mrinal Bhattacharya, Rui L. Reis, Vitor M. Correlo. Natural melanin nanoparticles (MNPs) extracted from Sepia officinalis: A cost-effective, chemo-photothermal, synergistic nanoplatform for osteosarcoma treatment. Colloids and Surfaces B: Biointerfaces 2024, 239 , 113937. https://doi.org/10.1016/j.colsurfb.2024.113937
- Wei Liu, Yue Sun, Bingshuai Zhou, Yifan Chen, Min Liu, Lin Wang, Manlin Qi, Bailong Liu, Biao Dong. Near-infrared light triggered upconversion nanocomposites with multifunction of enhanced antimicrobial photodynamic therapy and gas therapy for inflammation regulation. Journal of Colloid and Interface Science 2024, 663 , 834-846. https://doi.org/10.1016/j.jcis.2024.02.179
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