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Dihydrolevoglucosenone (Cyrene) as a Biobased Green Alternative to Organic Solvents for the Preparation of Supramolecular Gels Consisting of Self-Assembling Dipeptide Derivatives
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    Dihydrolevoglucosenone (Cyrene) as a Biobased Green Alternative to Organic Solvents for the Preparation of Supramolecular Gels Consisting of Self-Assembling Dipeptide Derivatives
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    • Shintaro Sugiura
      Shintaro Sugiura
      Department of Life Science and Chemistry, Graduate School of Natural Science and Technology, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan
      United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan
    • Yuki Shintani
      Yuki Shintani
      United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan
    • Sayuri L. Higashi
      Sayuri L. Higashi
      United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan
      Institute of Advanced Study, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan
      Center for One Medicine Innovative Translational Research (COMIT), Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan
    • Aya Shibata
      Aya Shibata
      Department of Life Science and Chemistry, Graduate School of Natural Science and Technology, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan
      More by Aya Shibata
    • Masato Ikeda*
      Masato Ikeda
      Department of Life Science and Chemistry, Graduate School of Natural Science and Technology, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan
      United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan
      Center for One Medicine Innovative Translational Research (COMIT), Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan
      Institute for Glyco-core Research (iGCORE), Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan
      Institute of Nano-Life-Systems, Institutes of Innovation for Future Society, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan
      *E-mail: [email protected]
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    Other Access OptionsSupporting Information (1)

    ACS Sustainable Chemistry & Engineering

    Cite this: ACS Sustainable Chem. Eng. 2024, 12, 4, 1420–1426
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    https://doi.org/10.1021/acssuschemeng.3c05026
    Published January 15, 2024
    Copyright © 2024 American Chemical Society

    Abstract

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    Herein, we describe the use of Cyrene, a biobased green solvent, to prepare supramolecular gels composed of self-assembling dipeptide derivatives. The gelation behavior was evaluated by using a conventional tube-inversion method. The basic properties, of the obtained supramolecular gels, including critical gel concentrations and viscoelastic properties, were assessed. In addition, the self-assembled fibrous network inside the gels was investigated via confocal laser scanning microscopy after fluorescence staining. The results offer important insights into the preparation of supramolecular gel-based materials with minimal environmental damage for practical applications.

    Copyright © 2024 American Chemical Society

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    Supporting Information

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    The Supporting Information is available free of charge at https://pubs.acs.org/doi/10.1021/acssuschemeng.3c05026.

    • Figures S1 and S2: Gelation test without heat treatment and FTIR spectra of xerogels of Fmoc- and Z-FF (PDF)

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    ACS Sustainable Chemistry & Engineering

    Cite this: ACS Sustainable Chem. Eng. 2024, 12, 4, 1420–1426
    Click to copy citationCitation copied!
    https://doi.org/10.1021/acssuschemeng.3c05026
    Published January 15, 2024
    Copyright © 2024 American Chemical Society

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