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Multi-Layered Plasma-Polymerized Chips for SPR-Based Detection

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Download Hi-Res ImageDownload to MS-PowerPointCite This:ACS Appl. Mater. Interfaces 2011, 3, 12, 4640-4648
    Research Article

    Multi-Layered Plasma-Polymerized Chips for SPR-Based Detection
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    † # †Biomedical Diagnostics Institute (BDI), ‡School of Biotechnology, and #School of Electronic Engineering, Dublin City University, Glasnevin, Dublin-9, Ireland
    § Research Centre in Physics of Matter and Radiation (PMR), University of Namur (FUNDP), 61, rue de Bruxelles, B-5000 Namur, Belgium
    || ⊥Research Centre for Surface and Materials Science, Department of Chemical and Materials Engineering, ||MacDiarmid Institute for Advanced Materials and Nanotechnology, Department of Chemistry, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand
    *E-mail: [email protected]. Phone: +353 1 7007984. Fax: +353 1 7006558.
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    ACS Applied Materials & Interfaces

    Cite this: ACS Appl. Mater. Interfaces 2011, 3, 12, 4640–4648
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    https://doi.org/10.1021/am201061k
    Published October 26, 2011
    Copyright © 2011 American Chemical Society
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    Abstract

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    The surface functionalization of a noble metal is crucial in a surface plasmon resonance-based biomolecular detection system because the interfacial coating must retain the activity of immobilized biomolecules while enhancing the optimal loading. We present here a one-step, room-temperature, high-speed, gas-phase plasma polymerization process for functionalizing gold substrates using siloxane as an adhesion layer and acrylic acid as a functional layer. Siloxane- and thiol-based coatings were compared for their performance as adhesion and the interfacial layer for subsequent functionalization. An in situ sequential deposition of siloxane and acrylic acid resulted in a 7-fold increase in carboxylic functionality surfacial content compared to films deposited with thiol-containing precursors. Grading of the layer composition achieved as a consequence of ion-induced mixing on the surface coating under the application of the plasma is confirmed through secondary ion mass spectroscopic studies. DNA hybridization assays were demonstrated on gold/glass substrates using surface plasmon enhanced ellipsometry and the applicability of this coating for protein immunoassays were demonstrated with plasma functionalized gold/plastic substrates in Biacore 3000 SPR instrument.

    Copyright © 2011 American Chemical Society

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    Supporting Information

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    The XPS survey spectrum, high-resolution C 1s and Si 2p core level spectra of TA and MA coatings, as well as SPR kinetic data from Biacore 3000 SPR instrument are given in the Supporting Informations. “This material is available free of charge via the Internet at http://pubs.acs.org.”

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    Cited By

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    This article is cited by 15 publications.

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    ACS Applied Materials & Interfaces

    Cite this: ACS Appl. Mater. Interfaces 2011, 3, 12, 4640–4648
    Click to copy citationCitation copied!
    https://doi.org/10.1021/am201061k
    Published October 26, 2011
    Copyright © 2011 American Chemical Society
    Request reuse permissions

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