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Role of Single-Walled Carbon Nanotubes on Ester Hydrolysis and Topography of Electrospun Bovine Serum Albumin/Poly(vinyl alcohol) Membranes

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Molecular Sciences and Engineering Team, Natick Soldier Research, Development and Engineering Center, Natick, Massachusetts 01760, United States
*R. Nagarajan. Address: Molecular Sciences and Engineering Team Natick Soldier Research, Development, and Engineering Center, 15 Kansas Street, Natick, MA 01760. Phone: 508 233 6445. Fax: 508 233 4469. E-mail: [email protected]
Cite this: ACS Appl. Mater. Interfaces 2014, 6, 14, 11741–11748
Publication Date (Web):July 9, 2014
https://doi.org/10.1021/am502495e
Copyright © This article not subject to U.S. Copyright. Published 2014 by the American Chemical Society
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Abstract

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Electrospun membranes were studied for the chemical deactivation of threat agents by means of enzymatic proteins. Protein loading and the surface chemistry of hybrid nanofibers influenced the efficacy by which embedded enzymes could digest the substrate of interest. Bovine serum albumin (BSA), selected as a model protein, was electrospun into biologically active fibers of poly(vinyl alcohol), PVA. Single-walled carbon nanotubes (SWNTs) were blended within these mixtures to promote protein assembly during the process of electrospinning and subsequently the ester hydrolysis of the substrates. The SWNT incorporation was shown to influence the topography of PVA/BSA nanofibers and enzymatic activity against paraoxon, a simulant for organophosphate agents and a phosphorus analogue of p-nitrophenyl acetate (PNA). The esterase activity of BSA against PNA was uncompromised upon its inclusion within nanofibrous membranes because similar amounts of PNA were hydrolyzed by BSA in solution and the electrospun BSA. However, the availability of BSA along the fiber surface was shown to affect the ester hydrolysis of paraoxon. Atomic force microscopy images of nanofibers implicated the surface migration of BSA during the electrospinning of SWNT filled dispersions, especially as greater weight fractions of protein were added to the spinning mixtures. In turn, the PVA/SWNT/BSA nanofibers outperformed the nanotube free PVA/BSA membranes in terms of paraoxon digestion. The results support the development of electrospun polymer nanofiber platforms, modulated by SWNTs for enzyme catalytic applications relevant to soldier protective ensembles.

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This article is cited by 6 publications.

  1. Yaewon Park, Preeti Rawat, and Ericka Ford . Role of Polymerized Micelles on the Calcium Carbonate Mineralization of Nanofibers. Industrial & Engineering Chemistry Research 2017, 56 (29) , 8241-8250. https://doi.org/10.1021/acs.iecr.7b00902
  2. Ruben Spitz Steinberg, Michelle Cruz, Naser G. A. Mahfouz, Yang Qiu, and Robert H. Hurt . Breathable Vapor Toxicant Barriers Based on Multilayer Graphene Oxide. ACS Nano 2017, 11 (6) , 5670-5679. https://doi.org/10.1021/acsnano.7b01106
  3. Jiang Liu, Nikolay A. Zorin, Meng Chen, and Dong-Jin Qian . Pd(II)-Directed Encapsulation of Hydrogenase within the Layer-by-Layer Multilayers of Carbon Nanotube Polyelectrolyte Used as a Heterogeneous Catalyst for Oxidation of Hydrogen. Langmuir 2015, 31 (23) , 6546-6553. https://doi.org/10.1021/acs.langmuir.5b01376
  4. Jing Wang, Wen-Li He, Meng Chen, Dong-Jin Qian. Fabrication of carbon nanotube-multiporphyrin array composites as light-sensitizer for photocurrent generation, photochromism of viologen and catalytic degradation of methyl orange. New Journal of Chemistry 2018, 42 (21) , 17216-17226. https://doi.org/10.1039/C8NJ03780A
  5. Matta Durga Prakash, Siva Vanjari, Chandra Sharma, Shiv Singh. Ultrasensitive, Label Free, Chemiresistive Nanobiosensor Using Multiwalled Carbon Nanotubes Embedded Electrospun SU-8 Nanofibers. Sensors 2016, 16 (9) , 1354. https://doi.org/10.3390/s16091354
  6. Alex M. Jordan, Vidya Viswanath, Si-Eun Kim, Jonathan K. Pokorski, LaShanda T. J. Korley. Processing and surface modification of polymer nanofibers for biological scaffolds: a review. Journal of Materials Chemistry B 2016, 4 (36) , 5958-5974. https://doi.org/10.1039/C6TB01303A

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