Strategies for Heterocyclic Construction via Novel Multicomponent Reactions Based on Isocyanides and Nucleophilic Carbenes

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14. Yi-Xin Si, Peng-Fei Zhu, Song-Lin Zhang. Synthesis of Isocyanides by Reacting Primary Amines with Difluorocarbene. Organic Letters 2020, 22 (22) , 9086-9090. https://doi.org/10.1021/acs.orglett.0c03472
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21. Jiuwei Che, Alavala Gopi Krishna Reddy, Li Niu, Dong Xing, Wenhao Hu. Cu(I)-Catalyzed Three-Component Reaction of α-Diazo Amide with Terminal Alkyne and Isatin Ketimine via Electrophilic Trapping of Active Alkynoate-Copper Intermediate. Organic Letters 2019, 21 (12) , 4571-4574. https://doi.org/10.1021/acs.orglett.9b01470
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23. Jinhuan Dong, Dawei Zhang, Yang Men, Xueming Zhang, Zhongyan Hu, Xianxiu Xu. [1 + 2 + 3] Annulation as a General Access to Indolo[3,2-b]carbazoles: Synthesis of Malasseziazole C. Organic Letters 2019, 21 (1) , 166-169. https://doi.org/10.1021/acs.orglett.8b03646
24. Pramod K. Sahu, Praveen K. Sahu, Manvendra S. Kaurav, Mouslim Messali, Saud M. Almutairi, Puran L. Sahu, Dau D. Agarwal. Metal-Free Construction of Fused Pyrimidines via Consecutive C–C and C–N Bond Formation in Water. ACS Omega 2018, 3 (11) , 15035-15042. https://doi.org/10.1021/acsomega.8b01993
25. Xinxin Lv, Zhenghui Kang, Dong Xing, Wenhao Hu. Cu(I)-Catalyzed Three-Component Reaction of Diazo Compound with Terminal Alkyne and Nitrosobenzene for the Synthesis of Trifluoromethyl Dihydroisoxazoles. Organic Letters 2018, 20 (16) , 4843-4847. https://doi.org/10.1021/acs.orglett.8b01981
26. Shengfeng Wu, Xiaofang Lei, Erkang Fan, and Zhihua Sun . Thermolysis-Induced Two- or Multicomponent Tandem Reactions Involving Isocyanides and Sulfenic-Acid-Generating Sulfoxides: Access to Diverse Sulfur-Containing Functional Scaffolds. Organic Letters 2018, 20 (3) , 522-525. https://doi.org/10.1021/acs.orglett.7b03593
27. Jian Zhang, Mingchang Wu, Wei Lu, Shuaifeng Wang, Yan Zhang, Cungui Cheng, and Gangguo Zhu . Preparation of 2-Amino-5-homoallylfurans via Palladium-Catalyzed Tandem Cycloisomerization/Heck-Type Coupling of Homoallenyl Amides with Allyltrialkylsilanes. The Journal of Organic Chemistry 2017, 82 (20) , 11134-11140. https://doi.org/10.1021/acs.joc.7b02131
28. Tamal Kanti Das, Santigopal Mondal, Rajesh G. Gonnade, and Akkattu T. Biju . Base-Free and Catalyst-Free Synthesis of Functionalized Dihydrobenzoxazoles via Vinylogous Carbonate to Carbamate Rearrangement. Organic Letters 2017, 19 (20) , 5597-5600. https://doi.org/10.1021/acs.orglett.7b02733
29. Yuelei Gao, Zhongyan Hu, Jinhuan Dong, Jun Liu, and Xianxiu Xu . Chemoselective Double Annulation of Two Different Isocyanides: Rapid Access to Trifluoromethylated Indole-Fused Heterocycles. Organic Letters 2017, 19 (19) , 5292-5295. https://doi.org/10.1021/acs.orglett.7b02582
30. Pei Xu, Fei Wang, Tian-Qi Wei, Ling Yin, Shun-Yi Wang, and Shun-Jun Ji . Palladium-Catalyzed Incorporation of Two C1 Building Blocks: The Reaction of Atmospheric CO2 and Isocyanides with 2-Iodoanilines Leading to the Synthesis of Quinazoline-2,4(1H,3H)-diones. Organic Letters 2017, 19 (17) , 4484-4487. https://doi.org/10.1021/acs.orglett.7b01877
31. Weigao Hu, Jia Zheng, Jianxiao Li, Bifu Liu, Wanqing Wu, Haiyang Liu, and Huanfeng Jiang . Assembly of Polysubstituted Maleimides via Palladium-Catalyzed Cyclization Reaction of Alkynes with Isocyanides. The Journal of Organic Chemistry 2016, 81 (24) , 12451-12458. https://doi.org/10.1021/acs.joc.6b02227
32. Kui Lu, Yantao Ma, Meile Gao, Yan Liu, Ming Li, Chuanming Xu, Xia Zhao, and Peng Yu . 1,4-Addition Ugi Reaction Using Cyclic α,β-Unsaturated Ketone as Substrate. Organic Letters 2016, 18 (19) , 5038-5041. https://doi.org/10.1021/acs.orglett.6b02493
33. Tao Lei, Wen-Qiang Liu, Jian Li, Mao-Yong Huang, Bing Yang, Qing-Yuan Meng, Bin Chen, Chen-Ho Tung, and Li-Zhu Wu . Visible Light Initiated Hantzsch Synthesis of 2,5-Diaryl-Substituted Pyrroles at Ambient Conditions. Organic Letters 2016, 18 (10) , 2479-2482. https://doi.org/10.1021/acs.orglett.6b01059
34. Ramagonolla Kranthikumar, Rambabu Chegondi, and Srivari Chandrasekhar . Insertion of N-Tosylacetimidates/Acetimidamides onto Arynes via [2 + 2] Cycloaddition. The Journal of Organic Chemistry 2016, 81 (6) , 2451-2459. https://doi.org/10.1021/acs.joc.5b02907
35. Zhen Zhang, Fan Xiao, Baoliang Huang, Jincheng Hu, Bin Fu, and Zhenhua Zhang . Cyclization of Alkyne–Azide with Isonitrile/CO via Self-Relay Rhodium Catalysis. Organic Letters 2016, 18 (5) , 908-911. https://doi.org/10.1021/acs.orglett.5b03570
36. Jian Zhang, Shao-Xia Lin, Dao-Juan Cheng, Xin-Yuan Liu, and Bin Tan . Phosphoric Acid-Catalyzed Asymmetric Classic Passerini Reaction. Journal of the American Chemical Society 2015, 137 (44) , 14039-14042. https://doi.org/10.1021/jacs.5b09117
37. Tsai-Wen Chung, Bharat D. Narhe, Chun-Cheng Lin, and Chung-Ming Sun . Multicomponent Synthesis of Functionalized Tetrahydroacridinones: Insights into a Mechanistic Route. Organic Letters 2015, 17 (21) , 5368-5371. https://doi.org/10.1021/acs.orglett.5b02705
38. Z. Tber, M.-A. Hiebel, A. El Hakmaoui, M. Akssira, G. Guillaumet, and S. Berteina-Raboin . Metal Free Formation of Various 3-Iodo-1H-pyrrolo[3′,2′:4,5]imidazo-[1,2-a]pyridines and [1,2-b]Pyridazines and Their Further Functionalization. The Journal of Organic Chemistry 2015, 80 (13) , 6564-6573. https://doi.org/10.1021/acs.joc.5b00555
39. Prabhakar Ramchandra Joshi, Sridhar Undeela, Doni Dhanoj Reddy, Kiran Kumar Singarapu, and Rajeev S. Menon . Regioselective Synthesis of Substituted Arenes via Aerobic Oxidative [3 + 3] Benzannulation Reactions of α,β-Unsaturated Aldehydes and Ketones. Organic Letters 2015, 17 (6) , 1449-1452. https://doi.org/10.1021/acs.orglett.5b00318
40. Cungui Cheng, Shuiyou Liu, and Gangguo Zhu . Palladium-Catalyzed Cycloisomerization and Aerobic Oxidative Cycloisomerization of Homoallenyl Amides: A Facile and Divergent Approach to 2-Aminofurans. Organic Letters 2015, 17 (6) , 1581-1584. https://doi.org/10.1021/acs.orglett.5b00464
41. Xian Feng, Jian-Jun Wang, Zhan Xun, Zhi-Bin Huang, and Da-Qing Shi . Multicomponent Strategy to Indeno[2,1-c]pyridine and Hydroisoquinoline Derivatives through Cleavage of Carbon–Carbon Bond. The Journal of Organic Chemistry 2015, 80 (2) , 1025-1033. https://doi.org/10.1021/jo5025199
42. Jie-Cheng Deng and Shih-Ching Chuang . Multicomponent Reactions of Phosphines, Diynedioates, and Aryl Aldehydes Generated Furans Appending Reactive Phosphorus Ylides through Cumulated Trienoates as Key Intermediates: A Phosphine α-Addition-δ-Evolvement of an Anion Pathway. Organic Letters 2014, 16 (21) , 5792-5795. https://doi.org/10.1021/ol502879c
43. Qing Jiang, Jing-Yu Wang, and Cancheng Guo . Iodine(III)-Mediated C–H Alkoxylation of Aniline Derivatives with Alcohols under Metal-Free Conditions. The Journal of Organic Chemistry 2014, 79 (18) , 8768-8773. https://doi.org/10.1021/jo501601u
44. Ying Han, Yin-Jian Sheng, and Chao-Guo Yan . Convenient Synthesis of Triphenylphosphanylidene Spiro[cyclopentane-1,3′-indolines] and Spiro[cyclopent[2]ene-1,3′-indolines] via Three-Component Reactions. Organic Letters 2014, 16 (10) , 2654-2657. https://doi.org/10.1021/ol5008394
45. Lei Fu, Wei Lin, Ming-Hua Hu, Xue-Cheng Liu, Zhi-Bin Huang, and Da-Qing Shi . Efficient Synthesis of Functionalized Benzo[b][1,8]naphthyridine Derivatives via Three-Component Reaction Catalyzed by l-Proline. ACS Combinatorial Science 2014, 16 (5) , 238-243. https://doi.org/10.1021/co4001524
46. Hong Gao, Jing Sun, and Chao-Guo Yan . Selective Synthesis of Functionalized Spiro[indoline-3,2′-pyridines] and Spiro[indoline-3,4′-pyridines] by Lewis Acid Catalyzed Reactions of Acetylenedicarboxylate, Arylamines, and Isatins. The Journal of Organic Chemistry 2014, 79 (9) , 4131-4136. https://doi.org/10.1021/jo500144z
47. Tao Fang, Qitao Tan, Zhengwei Ding, Bingxin Liu, and Bin Xu . Pd-Catalyzed Oxidative Annulation of Hydrazides with Isocyanides: Synthesis of 2-Amino-1,3,4-oxadiazoles. Organic Letters 2014, 16 (9) , 2342-2345. https://doi.org/10.1021/ol5006449
48. Annapureddy Rajasekar Reddy, Cong-Ying Zhou, and Chi-Ming Che . Ruthenium Porphyrin Catalyzed Three-Component Reaction of Diazo Compounds, Nitrosoarenes, and Alkynes: An Efficient Approach to Multifunctionalized Aziridines. Organic Letters 2014, 16 (4) , 1048-1051. https://doi.org/10.1021/ol4035098
49. Pramod K. Sahu, Praveen K. Sahu, Sushil K. Gupta, and Dau D. Agarwal . Chitosan: An Efficient, Reusable, and Biodegradable Catalyst for Green Synthesis of Heterocycles. Industrial & Engineering Chemistry Research 2014, 53 (6) , 2085-2091. https://doi.org/10.1021/ie402037d
50. Hai-Tao Yang, Xi-Chen Liang, Yan-Hong Wang, Yang Yang, Xiao-Qiang Sun, and Chun-Bao Miao . CuCl2-Mediated Reaction of [60]Fullerene with Amines in the Presence or Absence of Dimethyl Acetylenedicarboxylate: Preparation of Fulleropyrroline or Aziridinofullerene Derivatives. The Journal of Organic Chemistry 2013, 78 (23) , 11992-11998. https://doi.org/10.1021/jo402043p
51. Fenguo Zhou, Xu Liu, Ning Zhang, Yongjiu Liang, Rui Zhang, Xiaoqing Xin, and Dewen Dong . Copper-Catalyzed Three-Component Reaction: Solvent-Controlled Regioselective Synthesis of 4-Amino- and 6-Amino-2-iminopyridines. Organic Letters 2013, 15 (22) , 5786-5789. https://doi.org/10.1021/ol4028368
52. Mouhamad Jida, Cecilia Betti, Zofia Urbanczyk-Lipkowska, Dirk Tourwé, and Steven Ballet . Highly Diastereoselective Synthesis of 1-Carbamoyl-4-aminoindoloazepinone Derivatives via the Ugi Reaction. Organic Letters 2013, 15 (22) , 5866-5869. https://doi.org/10.1021/ol402940x
53. Bifu Liu, Hanling Gao, Yue Yu, Wanqing Wu, and Huanfeng Jiang . Palladium-Catalyzed Intermolecular Aerobic Oxidative Cyclization of 2-Ethynylanilines with Isocyanides: Regioselective Synthesis of 4-Halo-2-aminoquinolines. The Journal of Organic Chemistry 2013, 78 (20) , 10319-10328. https://doi.org/10.1021/jo401707j
54. Anup Bhunia, Digvijay Porwal, Rajesh G. Gonnade, and Akkattu T. Biju . Multicomponent Reactions Involving Arynes, Quinolines, and Aldehydes. Organic Letters 2013, 15 (17) , 4620-4623. https://doi.org/10.1021/ol4023134
55. Xiang Wang, Xiao-Ping Xu, Shun-Yi Wang, Weiqun Zhou, and Shun-Jun Ji . Highly Efficient Chemoselective Synthesis of Polysubstituted Pyrroles via Isocyanide-Based Multicomponent Domino Reaction. Organic Letters 2013, 15 (16) , 4246-4249. https://doi.org/10.1021/ol401976w
56. Min Yang, Jie Tang, and Renhua Fan . Dearomatization Strategy of β-Enamino Ester: Construction of Indenoazepines via Tandem Michael Addition/Polycyclization. Organic Letters 2013, 15 (13) , 3464-3467. https://doi.org/10.1021/ol401553n
57. Fleur Drouet, Géraldine Masson, and Jieping Zhu . Ugi Four-Component Reaction of Alcohols: Stoichiometric and Catalytic Oxidation/MCR Sequences. Organic Letters 2013, 15 (11) , 2854-2857. https://doi.org/10.1021/ol401181a
58. Xian Feng, Qian Wang, Wei Lin, Guo-Lan Dou, Zhi-Bin Huang, and Da-Qing Shi . Highly Efficient Synthesis of Polysubstituted Pyrroles via Four-Component Domino Reaction. Organic Letters 2013, 15 (10) , 2542-2545. https://doi.org/10.1021/ol4010382
59. Saurabh Mehta, Jesse P. Waldo, Benjamin Neuenswander, Gerald H. Lushington, and Richard C. Larock . Solution-Phase Parallel Synthesis of a Multisubstituted Cyclic Imidate Library. ACS Combinatorial Science 2013, 15 (5) , 247-254. https://doi.org/10.1021/co3001605
60. Anu Jose, K. C. Seetha Lakshmi, Eringathodi Suresh, and Vijay Nair . Phosphine-Mediated Reaction of 3-Alkyl Allenoates and Diaryl 1,2-Diones: Efficient Diastereoselective Synthesis of Fully Substituted Cyclopentenones. Organic Letters 2013, 15 (8) , 1858-1861. https://doi.org/10.1021/ol400467v
61. Li Zhang, Weibin Wang, and Renhua Fan . One-Pot Synthesis of Diarylamines from Two Aromatic Amines via Oxidative Dearomatization–Imino Exchange–Reductive Aromatization. Organic Letters 2013, 15 (8) , 2018-2021. https://doi.org/10.1021/ol4007162
62. Longyun Lv, Sichao Zheng, Xiaotie Cai, Zhipeng Chen, Qiuhua Zhu, and Shuwen Liu . Development of Four-Component Synthesis of Tetra- and Pentasubstituted Polyfunctional Dihydropyrroles: Free Permutation and Combination of Aromatic and Aliphatic Amines. ACS Combinatorial Science 2013, 15 (4) , 183-192. https://doi.org/10.1021/co300148c
63. Bifu Liu, Meizhou Yin, Hanling Gao, Wanqing Wu, and Huanfeng Jiang . Synthesis of 2-Aminobenzoxazoles and 3-Aminobenzoxazines via Palladium-Catalyzed Aerobic Oxidation of o-Aminophenols with Isocyanides. The Journal of Organic Chemistry 2013, 78 (7) , 3009-3020. https://doi.org/10.1021/jo400002f
64. T. Rajasekaran, G. Karthik, B. Sridhar, and B. V. Subba Reddy . Dual Behavior of Isatin-Based Cyclic Ketimines with Dicarbomethoxy Carbene: Expedient Synthesis of Highly Functionalized Spirooxindolyl Oxazolidines and Pyrrolines. Organic Letters 2013, 15 (7) , 1512-1515. https://doi.org/10.1021/ol400287q
65. Mehdi Ghandi, Ali-Tabatabaei Ghomi, and Maciej Kubicki . Synthesis of Cyclopentadiene-Fused Chromanones via One-Pot Multicomponent Reactions. The Journal of Organic Chemistry 2013, 78 (6) , 2611-2616. https://doi.org/10.1021/jo302790y
66. Ming Li, Xiu-Liang Lv, Li-Rong Wen, and Zhi-Qiang Hu . Direct Solvent-Free Regioselective Construction of Pyrrolo[1,2-a][1,10]phenanthrolines Based on Isocyanide-Based Multicomponent Reactions. Organic Letters 2013, 15 (6) , 1262-1265. https://doi.org/10.1021/ol400191b
67. Saurabh Mehta, Tuanli Yao, and Richard C. Larock . Regio- and Stereoselective Synthesis of Cyclic Imidates via Electrophilic Cyclization of 2-(1-Alkynyl)benzamides. A Correction. The Journal of Organic Chemistry 2012, 77 (23) , 10938-10944. https://doi.org/10.1021/jo301958q
68. Hongpeng Sun, Huayong Zhou, Oleg Khorev, Ruwei Jiang, Ting Yu, Xin Wang, Yongli Du, Yi Ma, Tao Meng, and Jingkang Shen . Three-Component, One-Pot Sequential Synthesis of Functionalized Cyclazines: 3H-1,2a1,3-Triazaacenaphthylenes. The Journal of Organic Chemistry 2012, 77 (23) , 10745-10751. https://doi.org/10.1021/jo3021105
69. Shashi Pandey, Shahnawaz Khan, Awantika Singh, Harsh M. Gauniyal, Brijesh Kumar, and Prem M. S. Chauhan . Access to Indole- And Pyrrole-Fused Diketopiperazines via Tandem Ugi-4CR/Intramolecular Cyclization and Its Regioselective Ring-Opening by Intermolecular Transamidation. The Journal of Organic Chemistry 2012, 77 (22) , 10211-10227. https://doi.org/10.1021/jo3018704
70. Orazio A. Attanasi, Silvia Bartoccini, Gianfranco Favi, Paolino Filippone, Francesca Romana Perrulli, and Stefania Santeusanio . Tandem Aza-Wittig/Carbodiimide-Mediated Annulation Applicable to 1,2-Diaza-1,3-dienes for the One-Pot Synthesis of Fully Substituted 1,2-Diaminoimidazoles. The Journal of Organic Chemistry 2012, 77 (20) , 9338-9343. https://doi.org/10.1021/jo301376z
71. Jing Sun, Yan Sun, Hui Gong, Ya-Jing Xie, and Chao-Guo Yan . Facile Synthesis of Dispirooxindole-Fused Heterocycles via Domino 1,4-Dipolar Addition and Diels–Alder Reaction of in Situ Generated Huisgen 1,4-Dipoles. Organic Letters 2012, 14 (20) , 5172-5175. https://doi.org/10.1021/ol302530m
72. Takeshi Hata, Haduki Imade, and Hirokazu Urabe . Four Nucleophilic Additions to Alkenynedioic Acid Derivatives in Tandem; Efficient One-Pot Synthesis of Bicyclo[4.2.0]octenols. Organic Letters 2012, 14 (10) , 2450-2453. https://doi.org/10.1021/ol300623j
73. Gonzalo Villaverde, Avelino Corma, Marta Iglesias, and Félix Sánchez . Heterogenized Gold Complexes: Recoverable Catalysts for Multicomponent Reactions of Aldehydes, Terminal Alkynes, and Amines. ACS Catalysis 2012, 2 (3) , 399-406. https://doi.org/10.1021/cs200601w
74. Ebrahim Soleimani and Mohsen Zainali . Isocyanide-Based Multicomponent Reactions: Synthesis of Alkyl-2-(1-(alkylcarbamoyl)-2,2-dicyanoethyl)benzoate and Isochromeno[3,4-b]pyrrole Derivatives. The Journal of Organic Chemistry 2011, 76 (24) , 10306-10311. https://doi.org/10.1021/jo201908f
75. Atul Kumar, Garima Gupta, and Suman Srivastava . Synthesis of New Class of Alkyl Azarene Pyridinium Zwitterions via Iodine Mediated sp3 C–H Bond Activation. Organic Letters 2011, 13 (24) , 6366-6369. https://doi.org/10.1021/ol202654j
76. Jingjing Ji, Xia Zhang, Yingguang Zhu, Yu Qian, Jing Zhou, Liping Yang, and Wenhao Hu . Diastereoselectivity Switch in Cooperatively Catalyzed Three-Component Reactions of an Aryldiazoacetate, an Alcohol, and a β,γ-Unsaturated α-Keto Ester. The Journal of Organic Chemistry 2011, 76 (14) , 5821-5824. https://doi.org/10.1021/jo102423c
77. Jing Sun, Er-Yan Xia, Qun Wu, and Chao-Guo Yan . Synthesis of 3,4-Dihydropyridin-2(1H)-ones and 3,4-Dihydro-2H-pyrans via Four-Component Reactions of Aromatic Aldehydes, Cyclic 1,3-Carbonyls, Arylamines, and Dimethyl Acetylenedicarboxylate. ACS Combinatorial Science 2011, 13 (4) , 421-426. https://doi.org/10.1021/co200045t
78. Orlando Pando, Sebastian Stark, Annika Denkert, Andrea Porzel, Rainer Preusentanz, and Ludger A. Wessjohann . The Multiple Multicomponent Approach to Natural Product Mimics: Tubugis, N-Substituted Anticancer Peptides with Picomolar Activity. Journal of the American Chemical Society 2011, 133 (20) , 7692-7695. https://doi.org/10.1021/ja2022027
79. Alan R. Katritzky, Davit Jishkariani, Rajeev Sakhuja, C. Dennis Hall, and Peter J. Steel . Carbene-Mediated Transformations of 1-(Benzylideneamino)benzimidazoles. The Journal of Organic Chemistry 2011, 76 (10) , 4082-4087. https://doi.org/10.1021/jo200088s
80. Jie-Cheng Deng and Shih-Ching Chuang . Three-Component and Nonclassical Reaction of Phosphines with Enynes and Aldehydes: Formation of γ-Lactones Featuring α-Phosphorus Ylides. Organic Letters 2011, 13 (9) , 2248-2251. https://doi.org/10.1021/ol200527t
81. Siang-en Syu, Yu-Ting Lee, Yeong-Jiunn Jang, and Wenwei Lin . Organocatalytic Tandem Three-Component Reaction of Imine, Alkyl Vinyl Ketone, and Imide via aza-Baylis−Hillman Reaction. The Journal of Organic Chemistry 2011, 76 (8) , 2888-2891. https://doi.org/10.1021/jo102143r
82. Tryfon Zarganes-Tzitzikas, Constantinos G. Neochoritis, Julia Stephanidou-Stephanatou, and Constantinos A. Tsoleridis . Synthesis of 2-Keto-imidazoles Utilizing N-Arylamino-Substituted N-Heterocyclic Carbenes. The Journal of Organic Chemistry 2011, 76 (5) , 1468-1471. https://doi.org/10.1021/jo102244x
83. Shaoyu Li and Jie Wu . Synthesis of H-Pyrazolo[5,1-a]isoquinolines via Copper(II)-Catalyzed Oxidation of an Aliphatic C−H Bond of Tertiary Amine in Air. Organic Letters 2011, 13 (4) , 712-715. https://doi.org/10.1021/ol102939r
84. Zhibin Huang, Yu Hu, Yao Zhou, and Daqing Shi. Efficient One-Pot Three-Component Synthesis of Fused Pyridine Derivatives in Ionic Liquid. ACS Combinatorial Science 2011, 13 (1) , 45-49. https://doi.org/10.1021/co1000162
85. Zhiyuan Chen and Jie Wu. Efficient Generation of Biologically Active H-Pyrazolo[5,1-a]isoquinolines via Multicomponent Reaction. Organic Letters 2010, 12 (21) , 4856-4859. https://doi.org/10.1021/ol101988q
86. Jing Sun, Er-Yan Xia, Qun Wu and Chao-Guo Yan. Synthesis of Polysubstituted Dihydropyridines by Four-Component Reactions of Aromatic Aldehydes, Malononitrile, Arylamines, and Acetylenedicarboxylate. Organic Letters 2010, 12 (16) , 3678-3681. https://doi.org/10.1021/ol101475b
87. Xiaofei Zeng, Kehan Ye, Min Lu, Pei Juan Chua, Bin Tan and Guofu Zhong. Chiral Brønsted Acid Catalyzed Enantioselective Addition of α-Isocyanoacetamides to Aldehydes. Organic Letters 2010, 12 (10) , 2414-2417. https://doi.org/10.1021/ol1007789
88. Julien Brioche, Géraldine Masson and Jieping Zhu. Passerini Three-Component Reaction of Alcohols under Catalytic Aerobic Oxidative Conditions. Organic Letters 2010, 12 (7) , 1432-1435. https://doi.org/10.1021/ol100012y
89. Yuling Li, Hui Chen, Chunling Shi, Daqing Shi and Shunjun Ji. Efficient One-Pot Synthesis of Spirooxindole Derivatives Catalyzed by l-Proline in Aqueous Medium. Journal of Combinatorial Chemistry 2010, 12 (2) , 231-237. https://doi.org/10.1021/cc9001185
90. Qi-Fang Wang, Li Hui, Hong Hou and Chao-Guo Yan. Synthesis of Zwitterionic Salts of Pyridinium-Meldrum Acid and Barbiturate through Unique Four-component Reactions. Journal of Combinatorial Chemistry 2010, 12 (2) , 260-265. https://doi.org/10.1021/cc900161z
91. Zhi-Liang Shen, Xiao-Ping Xu and Shun-Jun Ji. Brønsted Base-Catalyzed One-Pot Three-Component Biginelli-Type Reaction: An Efficient Synthesis of 4,5,6-Triaryl-3,4-dihydropyrimidin-2(1H)-one and Mechanistic Study. The Journal of Organic Chemistry 2010, 75 (4) , 1162-1167. https://doi.org/10.1021/jo902394y
92. Ramin Ghahremanzadeh, Ghazaleh Imani Shakibaei, Somayeh Ahadi and Ayoob Bazgir. One-Pot, Pseudo Four-Component Synthesis of a Spiro[diindeno[1,2-b:2′,1′-e]pyridine-11,3′-indoline]-trione Library. Journal of Combinatorial Chemistry 2010, 12 (1) , 191-194. https://doi.org/10.1021/cc900130a
93. Xian Huang and Jianfeng Xu . One-Pot Facile Synthesis of Substituted Isoindolinones via an Ugi Four-Component Condensation/Diels−Alder Cycloaddition/ Deselenization−Aromatization Sequence. The Journal of Organic Chemistry 2009, 74 (22) , 8859-8861. https://doi.org/10.1021/jo901628a
94. Tao Yue, Mei-Xiang Wang, De-Xian Wang, Géraldine Masson and Jieping Zhu . Catalytic Asymmetric Passerini-Type Reaction: Chiral Aluminum−Organophosphate-Catalyzed Enantioselective α-Addition of Isocyanides to Aldehydes. The Journal of Organic Chemistry 2009, 74 (21) , 8396-8399. https://doi.org/10.1021/jo9017765
95. Benito Alcaide, Pedro Almendros, Cristina Aragoncillo, Ricardo Callejo, M. Pilar Ruiz and M. Rosario Torres . Rhodium-Catalyzed Synthesis of 3-Hydroxy-β-lactams via Oxonium Ylide Generation: Three-Component Reaction between Azetidine-2,3-diones, Ethyl Diazoacetate, and Alcohols. The Journal of Organic Chemistry 2009, 74 (21) , 8421-8424. https://doi.org/10.1021/jo9019013
96. Donghui Wei and Mingsheng Tang. DFT Study on the Mechanisms of Stereoselective C(2)-Vinylation of 1-Substituted Imidazoles with 3-Phenyl-2-propynenitrile. The Journal of Physical Chemistry A 2009, 113 (41) , 11035-11041. https://doi.org/10.1021/jp9047874
97. Orazio A. Attanasi, Lucia De Crescentini, Gianfranco Favi, Paolino Filippone, Gianluca Giorgi, Fabio Mantellini, Giada Moscatelli and Mohamed S. Behalo. An Efficient One-Pot, Three-Component Synthesis of 5-Hydrazinoalkylidene Rhodanines from 1,2-Diaza-1,3-dienes. Organic Letters 2009, 11 (11) , 2265-2268. https://doi.org/10.1021/ol900545v
98. William Erb, Luc Neuville and Jieping Zhu. Ugi-Post Functionalization, from a Single Set of Ugi-Adducts to Two Distinct Heterocycles by Microwave-Assisted Palladium-Catalyzed Cyclizations: Tuning the Reaction Pathways by Ligand Switch. The Journal of Organic Chemistry 2009, 74 (8) , 3109-3115. https://doi.org/10.1021/jo900210x
99. Patrice Fontaine, Géraldine Masson and Jieping Zhu. Synthesis of Pyrroles by Consecutive Multicomponent Reaction/[4 + 1] Cycloaddition of α-Iminonitriles with Isocyanides. Organic Letters 2009, 11 (7) , 1555-1558. https://doi.org/10.1021/ol9001619
100. Limin Yang, Bin Tan, Fei Wang and Guofu Zhong. An Unexpected N-Heterocyclic Carbene-Catalyzed Annulation of Enals and Nitroso Compounds. The Journal of Organic Chemistry 2009, 74 (4) , 1744-1746. https://doi.org/10.1021/jo802515g