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The Synthesis and Chelation Chemistry of DOTA−Peptide Conjugates
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    The Synthesis and Chelation Chemistry of DOTA−Peptide Conjugates
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    University of Texas Southwestern Medical Center, Advanced Imaging Research Center, 2201 Inwood Road NE 4.2, Dallas, Texas 75390-8568
    * Corresponding author. UT Southwestern Medical Center, Advanced Imaging Research Center, 2201 Inwood Road NE 4.2, Dallas, TX 75390-8568 USA. Tel. +1 2146452755 , e-mail: [email protected]
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    Bioconjugate Chemistry

    Cite this: Bioconjugate Chem. 2008, 19, 2, 391–402
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    https://doi.org/10.1021/bc700328s
    Published December 12, 2007
    Copyright © 2008 American Chemical Society

    Abstract

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    Metal complexes of DOTA (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid)−peptide conjugates are increasingly used as targeted imaging and therapeutic radiopharmaceuticals and MRI contrast agents. This review covers the bifunctional derivatives of DOTA, the solution and solid-phase synthesis of DOTA−peptide conjugates, their coordination and chelation chemistry, and the biomedical applications of various DOTA−peptide conjugate metal complexes.

    Copyright © 2008 American Chemical Society

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    Bioconjugate Chemistry

    Cite this: Bioconjugate Chem. 2008, 19, 2, 391–402
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    https://doi.org/10.1021/bc700328s
    Published December 12, 2007
    Copyright © 2008 American Chemical Society

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