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Advances in Determination of a High-Resolution Three-Dimensional Structure of Rhodopsin, a Model of G-Protein-Coupled Receptors (GPCRs),

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Departments of Ophthalmology, Pharmacology, Chemistry, Biochemistry, and Biological Structure and Biomolecular Structure Center, University of Washington, Seattle, Washington 98195
Cite this: Biochemistry 2001, 40, 26, 7761–7772
Publication Date (Web):April 14, 2001
Copyright © 2001 American Chemical Society

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     This research was supported by NIH Grant EY-09339, awards from Research to Prevent Blindness, Inc. (RPB), to the Department of Ophthalmology at the University of Washington, the Foundation Fighting Blindness, the Ruth and Milton Steinbach Fund, and the E. K. Bishop Foundation. K.P. is a RPB Senior Investigator.

     The coordinates have been deposited in the Protein Data Bank as entry 1HZX.


     To whom correspondence should be addressed:  Department of Biochemistry, University of Washington, Box 357350, Seattle, WA 98195-7350. Phone:  (206) 543-1756. Fax:  (206) 685-1792. E-mail:  [email protected].


     Department of Biochemistry.

     Biomolecular Structure Center.

     Department of Ophthalmology.


     Present address:  Department of Biophysics, Graduate School of Science, Kyoto University, Kyoto 606-8502, Japan.$ Present address:  Emerald Biostructures, Bainbridge Island, WA 98110.


     Department of Pharmacology.% Department of Chemistry.& Department of Biological Structure.

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    Tabular listing of the following topics:  tilt of the helices, bends within helices, possible hydrogen bonds between helices, closest atoms to the 11-cis-retinal, retinal atoms closest to these protein atoms, and torsion angles for the chromophore. This material is available free of charge via the Internet at

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