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Ivermectin and Nodulisporic Acid Receptors in Drosophila melanogaster Contain Both γ-Aminobutyric Acid-Gated Rdl and Glutamate-Gated GluClα Chloride Channel Subunits

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Department of Parasite Biochemistry and Molecular Biology, Department of Drug Metabolism, Department of Basic Medicinal Chemistry, and Department of Ion Channels, Merck Research Laboratories, Rahway, New Jersey 07065
Cite this: Biochemistry 2002, 41, 20, 6548–6560
Publication Date (Web):April 23, 2002
https://doi.org/10.1021/bi015920o
Copyright © 2002 American Chemical Society
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    Abstract

    35S-labeled derivatives of the insecticides nodulisporic acid and ivermectin were synthesized and demonstrated to bind with high affinity to a population of receptors in Drosophila head membranes that were previously shown to be associated with a glutamate-gated chloride channel. Nodulisporic acid binding was modeled as binding to a single population of receptors. Ivermectin binding was composed of at least two kinetically distinct receptor populations, only one of which was associated with nodulisporic acid binding. The binding of these two ligands was modulated by glutamate, ivermectin, and antagonists of invertebrate γ-aminobutyric acid (GABA)ergic receptors. Because solubilized nodulisporic acid and ivermectin receptors comigrated as 230-kDa complexes by gel filtration, antisera specific for both the Drosophila glutamate-gated chloride channel subunit GluClα (DmGluClα) and the GABA-gated chloride channel subunit Rdl (DmRdl) proteins were generated and used to examine the possible coassembly of these two subunits within a single receptor complex. DmGluClα antibodies immunoprecipitated all of the ivermectin and nodulisporic acid receptors solubilized by detergent from Drosophila head membranes. DmRdl antibodies also immunoprecipitated all solubilized nodulisporic receptors, but only ∼70% of the ivermectin receptors. These data suggest that both DmGluClα and DmRdl are components of nodulisporic acid and ivermectin receptors, and that there also exists a distinct class of ivermectin receptors that contains the DmGluClα subunit but not the DmRdl subunit. This co-association of DmGluClα and DmRdl represents the first biochemical and immunological evidence of coassembly of subunits from two different subclasses of ligand-gated ion channel subunits.

    ‡

     Department of Parasite Biochemistry and Molecular Biology.

    #

     Department of Ion Channels.

    §

     Department of Basic Medicinal Chemistry.

    ⊥

     Department of Drug Metabolism.

    *

     To whom correspondence should be addressed at Merck Research Laboratories, R80N-31C, P.O. Box 2000, Rahway, NJ 07065. Phone:  (732) 594-7013. FAX:  (732) 594-3925. E-mail:  mchardy_smith@ merck.com.

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