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Influence of UDP-GlcNAc 2-Epimerase/ManNAc Kinase Mutant Proteins on Hereditary Inclusion Body Myopathy

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    Influence of UDP-GlcNAc 2-Epimerase/ManNAc Kinase Mutant Proteins on Hereditary Inclusion Body Myopathy†
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    Charité-Universitätsmedizin Berlin, Campus Benjamin Franklin, Institut für Biochemie und Molekularbiologie, Arnimallee 22, 14195 Berlin-Dahlem, Germany, Structural Biology Bioinformatics Unit, The Hebrew University-Hadassah Medical School, Jerusalem, Israel, Department of Pediatrics and Pediatric Neurology, University of Essen, Hufelandstrasse 55, 45122 Essen, Germany, Friedrich-Baur-Institute, Department of Neurology and Gene Center, Ludwig-Maximilians-University, Munich, Germany, and Goldyne Savad Institute of Gene Therapy, Hadassah Hebrew University Medical Center, Jerusalem, Israel
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    Biochemistry

    Cite this: Biochemistry 2006, 45, 9, 2968–2977
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    https://doi.org/10.1021/bi0522504
    Published February 10, 2006
    Copyright © 2006 American Chemical Society
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    Abstract

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    Hereditary inclusion body myopathy (HIBM), a neuromuscular disorder, is caused by mutations in UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE), the key enzyme of sialic acid biosynthesis. To date, more than 40 different mutations in the GNE gene have been reported to cause the disease. Ten of them, representing mutations in both functional domains of GNE, were recombinantly expressed in insect cells (Sf9). Each of the mutants that was analyzed displayed a reduction in the two known GNE activities, thus revealing that mutations may also influence the function of the domain not harboring them. The extent of reduction strongly differs among the point mutants, ranging from only 20% reduction found for A631T and A631V to almost 80% reduction of at least one activity in D378Y and N519S mutants and more than 80% reduction of both activities of G576E, underlined by structural changes of N519S and G576E, as observed in CD spectroscopy and gel filtration analysis, respectively. We therefore generated models of the three-dimensional structures of the epimerase and the kinase domains of GNE, based on Escherichia coli UDP-N-acetylglucosamine 2-epimerase and glucokinase, respectively, and determined the localization of the HIBM mutations within these proteins. Whereas in the kinase domain most of the mutations are localized inside the enzyme, mutations in the epimerase domain are mostly located at the protein surface. Otherwise, the different mutations result in different enzymatic activities but not in different disease phenotypes and, therefore, do not suggest a direct role of the enzymatic function of GNE in the disease mechanism.

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    †

     This work was supported by the Fritz-Thyssen-Stiftung, Köln, Germany (S.H. and S.M.-R.), the German-Israeli Foundation for Science Research & Development, Jerusalem, Israel (S.H. and S.M.-R.), the Association Francaise contre les Myopathies (S.M.-R.), the Mizutani Foundation for Glycoscience, Japan (S.M.-R.), the Deutsche Forschungsgemeinschaft, Bonn, Germany (L.L.; Lu 799/1-1), the Association Francaise contre les Myopathies (S.M.-R., S.C., and T.V.), and the Sonnenfeld-Stiftung, Berlin, Germany (S.H. and L.L.). S.K. receives a scholarship from The Myositis Association, Washington, DC.

    ‡

     Charité-Universitätsmedizin Berlin.

    §

     These authors contributed equally to this work.

    ‖

     The Hebrew University-Hadassah Medical School.

    ⊥

     University of Essen.

    @

     Ludwig-Maximilians-University.

    #

     Hadassah Hebrew University Medical Center.

    *

     To whom correspondence should be addressed:  Charité-Universitätsmedizin Berlin, Campus Benjamin Franklin, Institut für Biochemie und Molekularbiologie, Arnimallee 22, 14195 Berlin-Dahlem, Germany. Phone:  +49-30-8445-1547. Fax:  +49-30-8445-1541. E-mail:  [email protected].

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    This article is cited by 51 publications.

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    11. Hina Ishtiaq, Sonia Siddiqui, Rukhsana Nawaz, Khawar Saeed Jamali, Abdul Ghani Khan. Sialuria-Related Intellectual Disability in Children and Adolescent of Pakistan: Tenth Patient Described has a Novel Mutation in the GNE Gene. CNS & Neurological Disorders - Drug Targets 2020, 19 (2) , 127-141. https://doi.org/10.2174/1871527319666200213115747
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    13. Oksana Pogoryelova, José Andrés González Coraspe, Nikoletta Nikolenko, Hanns Lochmüller, Andreas Roos. GNE myopathy: from clinics and genetics to pathology and research strategies. Orphanet Journal of Rare Diseases 2018, 13 (1) https://doi.org/10.1186/s13023-018-0802-x
    14. Oksana Pogoryelova, Phillip Cammish, Hank Mansbach, Zohar Argov, Ichizo Nishino, Alison Skrinar, Yiumo Chan, Shahriar Nafissi, Hosein Shamshiri, Emil Kakkis, Hanns Lochmüller. Phenotypic stratification and genotype–phenotype correlation in a heterogeneous, international cohort of GNE myopathy patients: First report from the GNE myopathy Disease Monitoring Program, registry portion. Neuromuscular Disorders 2018, 28 (2) , 158-168. https://doi.org/10.1016/j.nmd.2017.11.001
    15. Jin-Mo Park, Jin-Hong Shin, Jin-Sung Park. GNE Myopathy with Prominent Axial Muscle Involvement. Journal of Clinical Neurology 2018, 14 (4) , 580. https://doi.org/10.3988/jcn.2018.14.4.580
    16. Xin Xu, Amy Q. Wang, Lea L. Latham, Frank Celeste, Carla Ciccone, May Christine Malicdan, Barry Goldspiel, Pramod Terse, James Cradock, Nora Yang, Selwyn Yorke, John C. McKew, William A. Gahl, Marjan Huizing, Nuria Carrillo. Safety, pharmacokinetics and sialic acid production after oral administration of N -acetylmannosamine (ManNAc) to subjects with GNE myopathy. Molecular Genetics and Metabolism 2017, 122 (1-2) , 126-134. https://doi.org/10.1016/j.ymgme.2017.04.010
    17. Nam D. Pham, Poh-Choo Pang, Soumya Krishnamurthy, Amberlyn M. Wands, Paola Grassi, Anne Dell, Stuart M. Haslam, Jennifer J. Kohler. Effects of altered sialic acid biosynthesis on N-linked glycan branching and cell surface interactions. Journal of Biological Chemistry 2017, 292 (23) , 9637-9651. https://doi.org/10.1074/jbc.M116.764597
    18. Sheng-Chia Chen, Chi-Hung Huang, Shu-Jung Lai, Chia Shin Yang, Tzu-Hung Hsiao, Ching-Heng Lin, Pin-Kuei Fu, Tzu-Ping Ko, Yeh Chen. Mechanism and inhibition of human UDP-GlcNAc 2-epimerase, the key enzyme in sialic acid biosynthesis. Scientific Reports 2016, 6 (1) https://doi.org/10.1038/srep23274
    19. Anke P. Willems, Baziel G.M. van Engelen, Dirk J. Lefeber. Genetic defects in the hexosamine and sialic acid biosynthesis pathway. Biochimica et Biophysica Acta (BBA) - General Subjects 2016, 1860 (8) , 1640-1654. https://doi.org/10.1016/j.bbagen.2015.12.017
    20. Dorit Bennmann, Wenke Weidemann, Annett Thate, Denise Kreuzmann, Rüdiger Horstkorte. Aberrant O‐Glc NA cylation disrupts GNE enzyme activity in GNE myopathy. The FEBS Journal 2016, 283 (12) , 2285-2294. https://doi.org/10.1111/febs.13729
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    22. Amina Chaouch, Kathryn M Brennan, Judith Hudson, Cheryl Longman, John McConville, Patrick J Morrison, Maria E Farrugia, Richard Petty, Willie Stewart, Fiona Norwood, Rita Horvath, Patrick F Chinnery, Donald Costigan, John Winer, Tuomo Polvikoski, Estelle Healy, Anna Sarkozy, Teresinha Evangelista, Oksana Pogoryelova, Michelle Eagle, Kate Bushby, Volker Straub, Hanns Lochmüller. Two recurrent mutations are associated with GNE myopathy in the North of Britain. Journal of Neurology, Neurosurgery & Psychiatry 2014, 85 (12) , 1359-1365. https://doi.org/10.1136/jnnp-2013-306314
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    24. Frank V. Celeste, Thierry Vilboux, Carla Ciccone, John Karl de Dios, May Christine V. Malicdan, Petcharat Leoyklang, John C. McKew, William A. Gahl, Nuria Carrillo-Carrasco, Marjan Huizing. Mutation Update for GNE Gene Variants Associated with GNE Myopathy. Human Mutation 2014, 35 (8) , 915-926. https://doi.org/10.1002/humu.22583
    25. Stephan Hinderlich, Wenke Weidemann, Tal Yardeni, Rüdiger Horstkorte, Marjan Huizing. UDP-GlcNAc 2-Epimerase/ManNAc Kinase (GNE): A Master Regulator of Sialic Acid Synthesis. 2013, 97-137. https://doi.org/10.1007/128_2013_464
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    28. Jacobo Martinez, Long Duc Nguyen, Stephan Hinderlich, Reinhold Zimmer, Eva Tauberger, Werner Reutter, Wolfram Saenger, Hua Fan, Sébastien Moniot. Crystal Structures of N-Acetylmannosamine Kinase Provide Insights into Enzyme Activity and Inhibition. Journal of Biological Chemistry 2012, 287 (17) , 13656-13665. https://doi.org/10.1074/jbc.M111.318170
    29. May Christine V. Malicdan, Satoru Noguchi, Ichizo Nishino. Function and Mutations of the GNE Gene Leading to Distal Myopathy with Rimmed Vacuoles/Hereditary Inclusion‐Body Myopathy, Animal Models, and Potential Treatment. 2012, 175-190. https://doi.org/10.1002/9781444398311.ch11
    30. Aldobrando Broccolini, Massimiliano Mirabella. Consequences of the hereditary inclusion‐body myopathy‐characteristic GNE mutations on muscle proteins in vivo and in vitro. 2012, 199-205. https://doi.org/10.1002/9781444398311.ch13
    31. Honghao Li, Qi Chen, Fuchen Liu, Xuemei Zhang, Tao Liu, Wei Li, Shuping Liu, Yuying Zhao, Bing Wen, Tingjun Dai, Pengfei Lin, Yaoqin Gong, Chuanzhu Yan. Clinical and molecular genetic analysis in Chinese patients with distal myopathy with rimmed vacuoles. Journal of Human Genetics 2011, 56 (4) , 335-338. https://doi.org/10.1038/jhg.2011.15
    32. Gregory Nemunaitis, Phillip B. Maples, Chris Jay, William A. Gahl, Marjan Huizing, Justin Poling, Alex W. Tong, Anagha P. Phadke, Beena O. Pappen, Cynthia Bedell, Nancy S. Templeton, Joseph Kuhn, Neil Senzer, John Nemunaitis. Hereditary inclusion body myopathy: single patient response to GNE gene Lipoplex therapy. The Journal of Gene Medicine 2010, 12 (5) , 403-412. https://doi.org/10.1002/jgm.1450
    33. Thomas Paccalet, Zoé Coulombe, Jacques P. Tremblay, . Ganglioside GM3 Levels Are Altered in a Mouse Model of HIBM: GM3 as a Cellular Marker of the Disease. PLoS ONE 2010, 5 (4) , e10055. https://doi.org/10.1371/journal.pone.0010055
    34. N. Kurochkina, T. Yardeni, M. Huizing. Molecular modeling of the bifunctional enzyme UDP-GlcNAc 2-epimerase/ManNAc kinase and predictions of structural effects of mutations associated with HIBM and sialuria. Glycobiology 2010, 20 (3) , 322-337. https://doi.org/10.1093/glycob/cwp176
    35. Hudson H. Freeze, Erik Eklund. Introduction to Human Glycosylation Disorders. 2010, 431-464. https://doi.org/10.1016/B978-0-12-373600-0.00017-2
    36. Yufeng Tong, Wolfram Tempel, Lyudmila Nedyalkova, Farrell MacKenzie, Hee-Won Park, . Crystal Structure of the N-Acetylmannosamine Kinase Domain of GNE. PLoS ONE 2009, 4 (10) , e7165. https://doi.org/10.1371/journal.pone.0007165
    37. Marjan Huizing, Donna M. Krasnewich. Hereditary Inclusion Body Myopathy: A decade of progress. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 2009, 1792 (9) , 881-887. https://doi.org/10.1016/j.bbadis.2009.07.001
    38. Stefan O. Reinke, Gerhard Lehmer, Stephan Hinderlich, Werner Reutter. Regulation and pathophysiological implications of UDP-GlcNAc 2-epimerase/ManNAc kinase (GNE) as the key enzyme of sialic acid biosynthesis. bchm 2009, 390 (7) , 591-599. https://doi.org/10.1515/BC.2009.073
    39. Anagha P. Phadke, Chris Jay, Salina J. Chen, Courtney Haddock, Zhaohui Wang, Yang Yu, Derek Nemunaitis, Gregory Nemunaitis, Nancy S. Templeton, Neil Senzer, Phillip B. Maples, Alex W. Tong, John Nemunaitis. Safety and in vivo Expression of a GNE-Transgene: A Novel Treatment Approach for Hereditary Inclusion Body Myopathy-2. Gene Regulation and Systems Biology 2009, 3 , GRSB.S2210. https://doi.org/10.4137/GRSB.S2210
    40. Chris M. Jay, Nick Levonyak, Gregory Nemunaitis, Phillip B. Maples, John Nemunaitis. Hereditary Inclusion Body Myopathy (HIBM2). Gene Regulation and Systems Biology 2009, 3 , GRSB.S2594. https://doi.org/10.4137/GRSB.S2594
    41. Iris Eisenberg, Noa Novershtern, Zohar Itzhaki, Michal Becker-Cohen, Menachem Sadeh, Peter H.G.M. Willems, Nir Friedman, Werner J.H. Koopman, Stella Mitrani-Rosenbaum. Mitochondrial processes are impaired in hereditary inclusion body myopathy. Human Molecular Genetics 2008, 17 (23) , 3663-3674. https://doi.org/10.1093/hmg/ddn261
    42. Alejandro Buschiazzo, Pedro M Alzari. Structural insights into sialic acid enzymology. Current Opinion in Chemical Biology 2008, 12 (5) , 565-572. https://doi.org/10.1016/j.cbpa.2008.06.017
    43. Maria Kontou, Wenke Weidemann, Christian Bauer, Werner Reutter, Rüdiger Horstkorte. The key enzyme of sialic acid biosynthesis (GNE) promotes neurite outgrowth of PC12 cells. NeuroReport 2008, 19 (12) , 1239-1242. https://doi.org/10.1097/WNR.0b013e32830b368a
    44. Ajit Varki. Sialic acids in human health and disease. Trends in Molecular Medicine 2008, 14 (8) , 351-360. https://doi.org/10.1016/j.molmed.2008.06.002
    45. Yadira Valles-Ayoub, Chai Saechao, Arman Haghighatgoo, Mehran S. Neshat, Saghi Esfandiarifard, Marvin Pietruszka, Daniel Darvish. Validation of GNE :p.M712T Identification by Melting Curve Analysis. Genetic Testing 2008, 12 (1) , 101-109. https://doi.org/10.1089/gte.2007.0034
    46. S. Krause, A. Aleo, S. Hinderlich, L. Merlini, I. Tournev, M. C. Walter, Z. Argov, S. Mitrani-Rosenbaum, H. Lochmüller. GNE protein expression and subcellular distribution are unaltered in HIBM. Neurology 2007, 69 (7) , 655-659. https://doi.org/10.1212/01.wnl.0000267426.97138.fd
    47. M. Needham, F.L. Mastaglia, M.J. Garlepp. Genetics of inclusion‐body myositis. Muscle & Nerve 2007, 35 (5) , 549-561. https://doi.org/10.1002/mus.20766
    48. Chun-Che Chu, Hung-Chou Kuo, Tu-Hsueh Yeh, Long-Sun Ro, Shyue-Ru Chen, Chin-Chang Huang. Heterozygous mutations affecting the epimerase domain of the GNE gene causing distal myopathy with rimmed vacuoles in a Taiwanese family. Clinical Neurology and Neurosurgery 2007, 109 (3) , 250-256. https://doi.org/10.1016/j.clineuro.2006.09.008
    49. E.A. Eklund, L. Bode, H.H. Freeze. Diseases Associated with Carbohydrates/Glycoconjugates*. 2007, 339-371. https://doi.org/10.1016/B978-044451967-2/00098-2
    50. Wenke Weidemann, Ulrich Stelzl, Ulrike Lisewski, Kaya Bork, Erich E. Wanker, Stephan Hinderlich, Rüdiger Horstkorte. The collapsin response mediator protein 1 (CRMP‐1) and the promyelocytic leukemia zinc finger protein (PLZF) bind to UDP‐ N ‐acetylglucosamine 2‐epimerase/ N ‐acetylmannosamine kinase (GNE), the key enzyme of sialic acid biosynthesis. FEBS Letters 2006, 580 (28-29) , 6649-6654. https://doi.org/10.1016/j.febslet.2006.11.015
    51. Zhiyun Wang, Zhonghui Sun, Adrienne V. Li, Kevin J. Yarema. Roles for UDP-GlcNAc 2-Epimerase/ManNAc 6-Kinase outside of Sialic Acid Biosynthesis. Journal of Biological Chemistry 2006, 281 (37) , 27016-27028. https://doi.org/10.1074/jbc.M604903200
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    Cite this: Biochemistry 2006, 45, 9, 2968–2977
    Click to copy citationCitation copied!
    https://doi.org/10.1021/bi0522504
    Published February 10, 2006
    Copyright © 2006 American Chemical Society
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