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Biologic Functions of the G12 Subfamily of Heterotrimeric G Proteins:  Growth, Migration, and Metastasis

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    Biologic Functions of the G12 Subfamily of Heterotrimeric G Proteins:  Growth, Migration, and Metastasis†
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    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, and Department of Biology, University of North Carolina at Asheville, Asheville, North Carolina 28804
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    Biochemistry

    Cite this: Biochemistry 2007, 46, 23, 6677–6687
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    https://doi.org/10.1021/bi700235f
    Published May 16, 2007
    Copyright © 2007 American Chemical Society
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    Abstract

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    The G12 subfamily of heterotrimeric G proteins has been the subject of intense scientific interest for more than 15 years. During this period, studies have revealed more than 20 potential G12-interacting proteins and numerous signaling axes emanating from the G12 proteins, Gα12 and Gα13. In addition, more recent studies have begun to illuminate the various and sundry functions that the G12 subfamily plays in biology. In this review, we summarize the diverse range of proteins that have been identified as Gα12 and/or Gα13 interactors and describe ongoing studies designed to dissect the biological roles of specific Gα−effector protein interactions. Further, we describe and discuss the expanding role of G12 proteins in the biology of cells, focusing on the distinct properties of this subfamily in regulating cell proliferation, cell migration, and metastatic invasion.

    Copyright © 2007 American Chemical Society

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    †

     We acknowledge support for this work from National Institutes of Health Grant CA100869 (to P.J.C. and T.E.M.) and the Duke University Medical School Alumni Scholarship (to P.K.).

    ‡

     Duke University Medical Center.

    *

     To whom correspondence should be addressed:  Department of Biology, University of North Carolina at Asheville, Asheville, NC 28804. Phone:  (828) 232-5155. Fax:  (828) 251-6623. E-mail:  [email protected].

    §

     University of North Carolina at Asheville.

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    Cite this: Biochemistry 2007, 46, 23, 6677–6687
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    https://doi.org/10.1021/bi700235f
    Published May 16, 2007
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