The Methyl-CpG Binding Transcriptional Repressor MeCP2 Stably Associates with Nucleosomal DNA†Click to copy article linkArticle link copied!
Abstract
We have investigated the interactions of the methyl-CpG binding transcriptional repressor MeCP2 with nucleosomal DNA. We find that MeCP2 forms discrete complexes with nucleosomal DNA associating with methyl-CpGs exposed in the major groove via the methyl-CpG-binding domain (MBD). In addition to the MBD, the carboxyl-terminal segment of MeCP2 facilitates binding both to naked DNA and to the nucleosome core. These observations provide a molecular mechanism by which MeCP2 can gain access to chromatin in order to target corepressor complexes that further modify chromatin structure.
†
S.P.C. is the recipient of a Wellcome Trust International Prize Fellowship.
*
To whom correspondence should be addressed. Tel: 301-402-2722. Fax: 301-402-1323. E-mail: [email protected].
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