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The Aβ Peptide of Alzheimer's Disease Directly Produces Hydrogen Peroxide through Metal Ion Reduction†

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Laboratory for Oxidation Biology, Genetics and Aging Unit, and Department of Psychiatry, Harvard Medical School, Massachusetts General Hospital, Charlestown, Massachusetts 02129, ZMBH−Center for Molecular Biology, Heidelberg, University of Heidelberg, Im Neuenheimer Feld 282, D-69120 Heidelberg, Germany, and Genetics and Aging Unit and Department of Neurology, Harvard Medical School, Massachusetts General Hospital, Charlestown, Massachusetts 02129
Cite this: Biochemistry 1999, 38, 24, 7609–7616
Publication Date (Web):May 27, 1999
https://doi.org/10.1021/bi990438f
Copyright © 1999 American Chemical Society
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Abstract

Oxidative stress markers characterize the neuropathology both of Alzheimer's disease and of amyloid-bearing transgenic mice. The neurotoxicity of amyloid Aβ peptides has been linked to peroxide generation in cell cultures by an unknown mechanism. We now show that human Aβ directly produces hydrogen peroxide (H2O2) by a mechanism that involves the reduction of metal ions, Fe(III) or Cu(II), setting up conditions for Fenton-type chemistry. Spectrophotometric experiments establish that the Aβ peptide reduces Fe(III) and Cu(II) to Fe(II) and Cu(I), respectively. Spectrochemical techniques are used to show that molecular oxygen is then trapped by Aβ and reduced to H2O2 in a reaction that is driven by substoichiometric amounts of Fe(II) or Cu(I). In the presence of Cu(II) or Fe(III), Aβ produces a positive thiobarbituric-reactive substance (TBARS) assay, compatible with the generation of the hydroxyl radical (OH·). The amounts of both reduced metal and TBARS reactivity are greatest when generated by Aβ1−42 ≫ Aβ1−40 > rat Aβ1−40, a chemical relationship that correlates with the participation of the native peptides in amyloid pathology. These findings indicate that the accumulation of Aβ could be a direct source of oxidative stress in Alzheimer's disease.

†

 This work was supported by funds from Prana Corp., NIH (1R29AG12686), Alliance for Aging Research (Paul Beeson Physician Faculty Scholar in Aging Research Award to A.I.B.), and the International Life Sciences Institute. X.H. is a recipient of a National Research Service Award (NIA).

‡

 Genetics and Aging Unit and Department of Psychiatry, Massachusetts General Hospital.

§

 University of Heidelberg.

‖

 Genetics and Aging Unit and Department of Neurology, Massachusetts General Hospital.

*

 Correspondence should be addressed to this author at the Laboratory for Oxidation Biology, Genetics and Aging Unit, Massachusetts General Hospital East, Building 149, 13th St., Charlestown, MA 02129. Phone:  617-726-8244. Fax:  617-724-9610. Email:  [email protected] helix.mgh.harvard.edu.

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