ACS Publications. Most Trusted. Most Cited. Most Read
CONTENT TYPES

Figure 1Loading Img

System Message

The ACS Publications site will be temporarily unavailable for planned maintenance on Friday, Oct. 15 starting at 6:00 pm ET for up to 4 hours. We apologize for this inconvenience.

pH-Triggered Aggregate Shape of Different Generations Lysine-Dendronized Maleimide Copolymers with Maltose Shell

View Author Information
Leibniz-Institut für Polymerforschung Dresden, Hohe Str. 6, 01109 Dresden, Germany
Technische Universität Dresden, D-01062 Dresden, Germany
Cite this: Biomacromolecules 2012, 13, 12, 4222–4235
Publication Date (Web):October 30, 2012
https://doi.org/10.1021/bm301489s
Copyright © 2012 American Chemical Society
Article Views
980
Altmetric
-
Citations
LEARN ABOUT THESE METRICS
Read OnlinePDF (3 MB)
Supporting Info (1)»

Abstract

Abstract Image

Glycopolymers are promising materials in the field of biomedical applications and in the fabrication of supramolecular structures with specific functions. For tunable design of supramolecular structures, glycopolymer architectures with specific properties (e.g., controlled self-assembly) are needed. Using the concept of dendronized polymers, a series of H-bond active giant glycomacromolecules with maleimide backbone and lysine dendrons of different generations were synthesized. They possess different macromolecular size and functionality along the backbone. Their peripheral maltose units lead to solubility under physiological conditions and controlled aggregation behavior. The aggregation behavior was investigated depending on generation number, pH value, and concentration. A portfolio of complementary analytical tools give an insight into the influence of the different parameters in shaping a rod-, coil-, and worm-like molecular structure and their controlled aggregate formation. MD simulation helped us to understand the complex aggregation behavior of the linear polymer chain without dendritic units.

Supporting Information

ARTICLE SECTIONS
Jump To

Additional experimental details. This material is available free of charge via the Internet at http://pubs.acs.org.

Terms & Conditions

Most electronic Supporting Information files are available without a subscription to ACS Web Editions. Such files may be downloaded by article for research use (if there is a public use license linked to the relevant article, that license may permit other uses). Permission may be obtained from ACS for other uses through requests via the RightsLink permission system: http://pubs.acs.org/page/copyright/permissions.html.

Cited By


This article is cited by 36 publications.

  1. Laura Plüschke, Anthony Ndiripo, Robert Mundil, Jan Merna, Harald Pasch, Albena Lederer. Unraveling Multiple Distributions in Chain Walking Polyethylene Using Advanced Liquid Chromatography. Macromolecules 2020, 53 (10) , 3765-3777. https://doi.org/10.1021/acs.macromol.0c00314
  2. Mariella Hannß, Raffaele Andrea Abbate, Eva Mitzenheim, Mahmoud Alkhalaf, Wendelin Böhm, Albena Lederer, Thomas Henle. Association of Enzymatically and Nonenzymatically Functionalized Caseins Analyzed by Size-Exclusion Chromatography and Light-Scattering Techniques. Journal of Agricultural and Food Chemistry 2020, 68 (9) , 2773-2782. https://doi.org/10.1021/acs.jafc.9b06592
  3. Albena Lederer Susanne Boye Dietmar Appelhans . Advanced AF4 Characterization of Dendritic Biomacromolecules, Their Self-Assembly, and Hybrid Formation. 2018,,, 171-187. https://doi.org/10.1021/bk-2018-1281.ch009
  4. Susanne Boye, Franka Ennen, Linda Scharfenberg, Dietmar Appelhans, Lars Nilsson, and Albena Lederer . From 1D Rods to 3D Networks: A Biohybrid Topological Diversity Investigated by Asymmetrical Flow Field-Flow Fractionation. Macromolecules 2015, 48 (13) , 4607-4619. https://doi.org/10.1021/acs.macromol.5b00824
  5. Michael Wagner, Stephan Holzschuh, Anja Traeger, Alfred Fahr, and Ulrich. S. Schubert . Asymmetric Flow Field-Flow Fractionation in the Field of Nanomedicine. Analytical Chemistry 2014, 86 (11) , 5201-5210. https://doi.org/10.1021/ac501664t
  6. Johanna Majoinen, Johannes S. Haataja, Dietmar Appelhans, Albena Lederer, Anna Olszewska, Jani Seitsonen, Vladimir Aseyev, Eero Kontturi, Henna Rosilo, Monika Österberg, Nikolay Houbenov, and Olli Ikkala . Supracolloidal Multivalent Interactions and Wrapping of Dendronized Glycopolymers on Native Cellulose Nanocrystals. Journal of the American Chemical Society 2014, 136 (3) , 866-869. https://doi.org/10.1021/ja411401r
  7. Christine L. Plavchak, William C. Smith, Carmen R.M. Bria, S. Kim Ratanathanawongs Williams. New Advances and Applications in Field-Flow Fractionation. Annual Review of Analytical Chemistry 2021, 14 (1) , 257-279. https://doi.org/10.1146/annurev-anchem-091520-052742
  8. Janek Weißpflog, David Vehlow, Martin Müller, Benjamin Kohn, Ulrich Scheler, Susanne Boye, Simona Schwarz. Characterization of chitosan with different degree of deacetylation and equal viscosity in dissolved and solid state – Insights by various complimentary methods. International Journal of Biological Macromolecules 2021, 171 , 242-261. https://doi.org/10.1016/j.ijbiomac.2021.01.010
  9. Michael Toney, Luca Baiamonte, William C. Smith, S. Kim Ratanathanwongs Williams. Field-flow fractionation techniques for polymer characterization. 2021,,, 129-171. https://doi.org/10.1016/B978-0-12-819768-4.00004-X
  10. Albena Lederer, Josef Brandt. Multidetector size exclusion chromatography of polymers. 2021,,, 61-96. https://doi.org/10.1016/B978-0-12-819768-4.00012-9
  11. Jingjing Li, Yonggang Liu, Quan Chen. Conformation of dilute poly(vinyl alcohol)-borax complex by asymmetric flow field-flow fractionation. Journal of Chromatography A 2020, 1624 , 461260. https://doi.org/10.1016/j.chroma.2020.461260
  12. Xiong Liu, Wei Lin, Didier Astruc, Haibin Gu. Syntheses and applications of dendronized polymers. Progress in Polymer Science 2019, 96 , 43-105. https://doi.org/10.1016/j.progpolymsci.2019.06.002
  13. Hannes Gumz, Susanne Boye, Banu Iyisan, Vera Krönert, Petr Formanek, Brigitte Voit, Albena Lederer, Dietmar Appelhans. Toward Functional Synthetic Cells: In‐Depth Study of Nanoparticle and Enzyme Diffusion through a Cross‐Linked Polymersome Membrane. Advanced Science 2019, 6 (7) , 1801299. https://doi.org/10.1002/advs.201801299
  14. Andrew M. Lunn, Sébastien Perrier. Synthesis of Sub-100 nm Glycosylated Nanoparticles via a One Step, Free Radical, and Surfactant Free Emulsion Polymerization. Macromolecular Rapid Communications 2018, 39 (19) , 1800122. https://doi.org/10.1002/marc.201800122
  15. Eero Kontturi, Päivi Laaksonen, Markus B. Linder, Nonappa, André H. Gröschel, Orlando J. Rojas, Olli Ikkala. Advanced Materials through Assembly of Nanocelluloses. Advanced Materials 2018, 30 (24) , 1703779. https://doi.org/10.1002/adma.201703779
  16. Norbert Raak, Raffaele Abbate, Albena Lederer, Harald Rohm, Doris Jaros. Size Separation Techniques for the Characterisation of Cross-Linked Casein: A Review of Methods and Their Applications. Separations 2018, 5 (1) , 14. https://doi.org/10.3390/separations5010014
  17. Yamin Abdouni, Gokhan Yilmaz, C. Remzi Becer. Sequence and Architectural Control in Glycopolymer Synthesis. 2017,,, 229-256. https://doi.org/10.1002/9783527806096.ch8
  18. Yamin Abdouni, Gokhan Yilmaz, C. Remzi Becer. Sequence and Architectural Control in Glycopolymer Synthesis. Macromolecular Rapid Communications 2017, 38 (24) , 1700212. https://doi.org/10.1002/marc.201700212
  19. S. Kim Ratanathanawongs Williams, Maria-Anna Benincasa, William C. Smith, James D. Oliver. Field-Flow Fractionation in Analysis of Polymers and Rubbers. 2016,,, 1-33. https://doi.org/10.1002/9780470027318.a2008.pub3
  20. Muhammad Imran Malik, Harald Pasch. Field-flow fractionation: New and exciting perspectives in polymer analysis. Progress in Polymer Science 2016, 63 , 42-85. https://doi.org/10.1016/j.progpolymsci.2016.03.004
  21. Xiaoxia Wang, Can Jin, Qiaorong Han, Yuliang Jiang, Fanyang Zeng, Zhenye Ma, Bingxiang Wang. Synthesis, Self-Assembly, and Host-Guest Response of Naphthalic Anhydride-Ended Hyperbranched Polyesters. Macromolecular Chemistry and Physics 2016, 217 (9) , 1057-1064. https://doi.org/10.1002/macp.201500452
  22. Alexander Filippov, Arkadij Kozlov, Elena Tarabukina, Marina Obrezkova, Aziz Muzafarov. Solution properties of comb-like polymers consisting of dimethylsiloxane monomer units. Polymer International 2016, 65 (4) , 393-399. https://doi.org/10.1002/pi.5067
  23. . Analytical Methods. 2016,,, 113-186. https://doi.org/10.1002/9781119188896.ch4
  24. Emi Haladjova, Stanislav Rangelov, Martin Geisler, Susanne Boye, Albena Lederer, Grigoris Mountrichas, Stergios Pispas. Asymmetric Flow Field-Flow Fractionation Investigation of Magnetopolyplexes. Macromolecular Chemistry and Physics 2015, 216 (18) , 1862-1867. https://doi.org/10.1002/macp.201500177
  25. Michael Wagner, Christian Pietsch, Andreas Kerth, Anja Traeger, Ulrich S. Schubert. Physicochemical characterization of the thermo-induced self-assembly of thermo-responsive PDMAEMA- b -PDEGMA copolymers. Journal of Polymer Science Part A: Polymer Chemistry 2015, 53 (7) , 924-935. https://doi.org/10.1002/pola.27520
  26. Fiona L. Hatton, Eva Malmström, Anna Carlmark. Tailor-made copolymers for the adsorption to cellulosic surfaces. European Polymer Journal 2015, 65 , 325-339. https://doi.org/10.1016/j.eurpolymj.2015.01.026
  27. Dietmar Appelhans, Barbara Klajnert-Maculewicz, Anna Janaszewska, Joanna Lazniewska, Brigitte Voit. Dendritic glycopolymers based on dendritic polyamine scaffolds: view on their synthetic approaches, characteristics and potential for biomedical applications. Chemical Society Reviews 2015, 44 (12) , 3968-3996. https://doi.org/10.1039/C4CS00339J
  28. Rajendra Aluri, Manickam Jayakannan. One-pot two polymers: ABB′ melt polycondensation for linear polyesters and hyperbranched poly(ester-urethane)s based on natural l -amino acids. Polymer Chemistry 2015, 6 (25) , 4641-4649. https://doi.org/10.1039/C5PY00602C
  29. Meng Huo, Qiquan Ye, Hailong Che, Mengzhen Sun, Jinying Yuan, Yen Wei. Synthesis and self-assembly of CO 2 -responsive dendronized triblock copolymers. Polymer Chemistry 2015, 6 (42) , 7427-7435. https://doi.org/10.1039/C5PY00868A
  30. I. V. Mikhailov, A. A. Darinskii, E. B. Zhulina, O. V. Borisov, F. A. M. Leermakers. Persistence length of dendronized polymers: the self-consistent field theory. Soft Matter 2015, 11 (48) , 9367-9378. https://doi.org/10.1039/C5SM01620G
  31. Josef Brandt, Kim K. Oehlenschlaeger, Friedrich Georg Schmidt, Christopher Barner-Kowollik, Albena Lederer. State-of-the-Art Analytical Methods for Assessing Dynamic Bonding Soft Matter Materials. Advanced Materials 2014, 26 (33) , 5758-5785. https://doi.org/10.1002/adma.201400521
  32. Krzysztof Babiuch, Martina H. Stenzel. Synthesis and Application of Glycopolymers. 2014,,, 1-58. https://doi.org/10.1002/0471440264.pst618
  33. Andrea Zattoni, Barbara Roda, Francesco Borghi, Valentina Marassi, Pierluigi Reschiglian. Flow field-flow fractionation for the analysis of nanoparticles used in drug delivery. Journal of Pharmaceutical and Biomedical Analysis 2014, 87 , 53-61. https://doi.org/10.1016/j.jpba.2013.08.018
  34. Franka Ennen, Susanne Boye, Albena Lederer, Mihaela Cernescu, Hartmut Komber, Bernhard Brutschy, Brigitte Voit, Dietmar Appelhans. Biohybrid structures consisting of biotinylated glycodendrimers and proteins: influence of the biotin ligand's number and chemical nature on the biotin–avidin conjugation. Polym. Chem. 2014, 5 (4) , 1323-1339. https://doi.org/10.1039/C3PY01152F
  35. Michael Wagner, Markus J. Barthel, Robert R. A. Freund, Stephanie Hoeppener, Anja Traeger, Felix H. Schacher, Ulrich S. Schubert. Solution self-assembly of poly(ethylene oxide)-block-poly(furfuryl glycidyl ether)-block-poly(allyl glycidyl ether) based triblock terpolymers: a field-flow fractionation study. Polym. Chem. 2014, 5 (24) , 6943-6956. https://doi.org/10.1039/C4PY00863D
  36. Mingsheng Chen, Xinyuan Zhu, Deyue Yan. A controlled release system for simultaneous promotion of gene transfection and antitumor effects. RSC Adv. 2014, 4 (110) , 64596-64600. https://doi.org/10.1039/C4RA10447A

Pair your accounts.

Export articles to Mendeley

Get article recommendations from ACS based on references in your Mendeley library.

Pair your accounts.

Export articles to Mendeley

Get article recommendations from ACS based on references in your Mendeley library.

You’ve supercharged your research process with ACS and Mendeley!

STEP 1:
Click to create an ACS ID

Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

MENDELEY PAIRING EXPIRED
Your Mendeley pairing has expired. Please reconnect

This website uses cookies to improve your user experience. By continuing to use the site, you are accepting our use of cookies. Read the ACS privacy policy.

CONTINUE