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Multivalent Anchoring and Cross-Linking of Mussel-Inspired Antifouling Surface Coatings

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§ Multifunctional Biomaterials for Medicine, Helmholtz Virtual Institute, Kantstr. 55, 14513 Teltow-Seehof, Germany
Fraunhofer Institute for Manufacturing Technology and Advanced Materials (FhG IFAM), Wiener Str. 12, 28359 Bremen, Germany
Department of Chemistry and Biochemistry, Freie Universität Berlin, Takustr. 3, 14195 Berlin, Germany
*Tel: 0049-0-30 838 52633. Fax: 0049-0-30 838 53357. E-mail: [email protected]
Cite this: Biomacromolecules 2014, 15, 8, 3061–3071
Publication Date (Web):June 27, 2014
https://doi.org/10.1021/bm500673u
Copyright © 2014 American Chemical Society
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Abstract

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In this work, we combine nature’s amazing bioadhesive catechol with the excellent bioinert synthetic macromolecule hyperbranched polyglycerol (hPG) to prepare antifouling surfaces. hPG can be functionalized by different amounts of catechol groups for multivalent anchoring and cross-linking because of its highly branched architecture. The catecholic hPGs can be immobilized on various surfaces including metal oxides, noble metals, ceramics, and polymers via simple incubation procedures. The effect of the catechol amount on the immobilization, surface morphology, stability, and antifouling performance of the coatings was studied. Both anchoring and cross-linking interactions provided by catechols can enhance the stability of the coatings. When the catechol groups on the hPG are underrepresented, the tethering of the coating is not effective; while an overrepresentation of catechol groups leads to protein adsorption and cell adhesion. Thus, only a well-balanced amount of catechols as optimized and described in this work can supply the coatings with both good stability and antifouling ability.

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Details of the synthesis, characterization of compounds and coatings, protein adsorption from human plasma, albumin adsorption on polypropylene and glass, cell adhesion, and cytotoxicity tests. This material is available free of charge via the Internet at http://pubs.acs.org.

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