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PICKScreens, A New Database for the Comparison of Crystallization Screens for Biological Macromolecules
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    PICKScreens, A New Database for the Comparison of Crystallization Screens for Biological Macromolecules
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    Published as part of the Crystal Growth & Design virtual special issue on the 13th International Conference on the Crystallization of Biological Macromolecules (ICCBM13).

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    Department of Molecular Membrane Biology, Max Planck Institute of Biophysics, Max von Laue Strasse 3, D-60438 Frankfurt am Main, Germany
    *Corresponding author. E-mail: [email protected]. Telephone: 0049-(0)69-63031000. Fax: 0049-(0)69-63031002.
    #Current address: Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520, USA.
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    Crystal Growth & Design

    Cite this: Cryst. Growth Des. 2011, 11, 2, 488–491
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    https://doi.org/10.1021/cg101267n
    Published December 31, 2010
    Copyright © 2010 American Chemical Society

    Abstract

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    Extensive screening during crystallization trials is necessary, especially for challenging but interesting targets, that is, large multisubunit complexes or membrane proteins. Producing high amounts of such macromolecules is difficult, so it is important to perform screening efficiently. However, commercial screens are redundant, leading to unnecessary or unwanted sample consumption, and cannot be visually compared, because the manufacturers’ formulations are not formatted uniformly. PICKScreens, a database reporting Profile of Identities among Crystallization Kit Screens, will help crystallographers “pick” screens in a more rational manner, minimizing sample consumption and hopefully enhancing their success rate. It is available at https://registration.cc.biophys.mpg.de/fam-core/.

    Copyright © 2010 American Chemical Society

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    This article is cited by 9 publications.

    1. Janet Newman and Joseph R. Luft . 13th International Conference on the Crystallization of Biological Macromolecules (ICCBM13) Proceedings Overview. Crystal Growth & Design 2012, 12 (1) , 3-7. https://doi.org/10.1021/cg201206e
    2. Valerie E. Pye, David Aragão, Joseph A. Lyons, and Martin Caffrey . Overview of the 13th International Conference on the Crystallization of Biological Macromolecules. Crystal Growth & Design 2011, 11 (11) , 4723-4730. https://doi.org/10.1021/cg101379p
    3. Midusha Shrestha, Truong X. Tran, Bidhan Bhattarai, Marc L. Pusey, Ramazan S. Aygun. Schema Matching and Data Integration with Consistent Naming on Protein Crystallization Screens. IEEE/ACM Transactions on Computational Biology and Bioinformatics 2020, 17 (6) , 2074-2085. https://doi.org/10.1109/TCBB.2019.2913368
    4. Nicholas Rosa, Marko Ristic, Luke Thorburn, Gabriel Abrahams, Bevan Marshall, Christopher Watkins, Alex Kruger, Alex Khassapov, Janet Newman. Tools to Ease the Choice and Design of Protein Crystallisation Experiments. Crystals 2020, 10 (2) , 95. https://doi.org/10.3390/cryst10020095
    5. David Quirnheim Pais, Barbara Rathmann, Juergen Koepke, Cveta Tomova, Paul Wurzinger, Yvonne Thielmann. A standardized technique for high-pressure cooling of protein crystals. Acta Crystallographica Section D Structural Biology 2017, 73 (12) , 997-1006. https://doi.org/10.1107/S2059798317016357
    6. Richard Giegé. A historical perspective on protein crystallization from 1840 to the present day. FEBS Journal 2013, 280 (24) , 6456-6497. https://doi.org/10.1111/febs.12580
    7. Florian G. Müller, C. Roy D. Lancaster. Crystallization of Membrane Proteins. 2013, 67-83. https://doi.org/10.1007/978-1-62703-487-6_5
    8. Yvonne Thielmann, Juergen Koepke, Hartmut Michel. The ESFRI Instruct Core Centre Frankfurt: automated high-throughput crystallization suited for membrane proteins and more. Journal of Structural and Functional Genomics 2012, 13 (2) , 63-69. https://doi.org/10.1007/s10969-011-9118-y
    9. Fabrice Gorrec, Colin M. Palmer, Guillaume Lebon, Tony Warne. Pi sampling: a methodical and flexible approach to initial macromolecular crystallization screening. Acta Crystallographica Section D Biological Crystallography 2011, 67 (5) , 463-470. https://doi.org/10.1107/S0907444911008754

    Crystal Growth & Design

    Cite this: Cryst. Growth Des. 2011, 11, 2, 488–491
    Click to copy citationCitation copied!
    https://doi.org/10.1021/cg101267n
    Published December 31, 2010
    Copyright © 2010 American Chemical Society

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