Coiled-Coils in Phage Display Screening: Insight into Exceptional Selectivity Provided by Molecular Dynamics
- Jérémie Mortier
- Elisabeth K. Nyakatura
- Oliver Reimann
- Susanne Huhmann
- Jan O. Daldrop
- Carsten Baldauf
- Gerhard Wolber
- Markus S. Miettinen
- , and
- Beate Koksch
Involved in numerous key biological functions, protein helix–helix interactions follow a well-defined intermolecular recognition pattern. The characteristic structure of the α-helical coiled-coil allows for the specific randomization of clearly defined interaction partners within heteromeric systems. In this work, a rationally designed heterodimeric coiled-coil was used to investigate potential factors influencing the sequence selectivity in interhelical interactions.
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