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    The Chemical Nature of Mercury in Human Brain Following Poisoning or Environmental Exposure
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    † Department of Geological Sciences, University of Saskatchewan, 114 Science Place, Saskatoon, Saskatchewan S7N 5E2, Canada
    ‡ Department of Environmental Medicine
    § Eastman Institute for Oral Health
    ⊥ Departments of Neurology and Pediatrics
    School of Medicine and Dentistry, University of Rochester, 601 Elmwood Avenue, Rochester, New York 14642, United States
    *To whom correspondence may be addressed. E-mail: [email protected]. Phone: (+1) 306 966 5722. Fax: (+1) 306 966 8593.
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    ACS Chemical Neuroscience

    Cite this: ACS Chem. Neurosci. 2010, 1, 12, 810–818
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    https://doi.org/10.1021/cn1000765
    Published October 15, 2010
    Copyright © 2010 American Chemical Society
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    Methylmercury is among the most potentially toxic species to which human populations are exposed, both at high levels through poisonings and at lower levels through consumption of fish and other seafood. However, the molecular mechanisms of methylmercury toxicity in humans remain poorly understood. We used synchrotron X-ray absorption spectroscopy (XAS) to study mercury chemical forms in human brain tissue. Individuals poisoned with high levels of methylmercury species showed elevated cortical selenium with significant proportions of nanoparticulate mercuric selenide plus some inorganic mercury and methylmercury bound to organic sulfur. Individuals with a lifetime of high fish consumption showed much lower levels of mercuric selenide and methylmercury cysteineate. Mercury exposure did not perturb organic selenium levels. These results elucidate a key detoxification pathway in the central nervous system and provide new insights into the appropriate methods for biological monitoring.

    Copyright © 2010 American Chemical Society

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    Cite this: ACS Chem. Neurosci. 2010, 1, 12, 810–818
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    Published October 15, 2010
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