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Multisite Intracerebral Microdialysis to Study the Mechanism of L-DOPA Induced Dopamine and Serotonin Release in the Parkinsonian Brain
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    Multisite Intracerebral Microdialysis to Study the Mechanism of L-DOPA Induced Dopamine and Serotonin Release in the Parkinsonian Brain
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    † ‡ Université de Bordeaux and Centre National de la Recherche Scientifique, Unité Mixte de Recherche 5293, 33076 Bordeaux Cedex, France
    *Mailing address: Institut des Maladies Neurodégénératives - Université Bordeaux Segalen, 146, rue Léo Saignât, 33076 Bordeaux, France. Tel.: +33 (0) 557 57 46 19. Fax +33 (0) 556 90 14 21. E-mail: [email protected]
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    ACS Chemical Neuroscience

    Cite this: ACS Chem. Neurosci. 2013, 4, 5, 680–692
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    https://doi.org/10.1021/cn400046e
    Published March 31, 2013
    Copyright © 2013 American Chemical Society

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    L-DOPA is currently one of the best medications for Parkinson’s disease. It was assumed for several years that its benefits and side effects were related to the enhancement of dopamine release in the dopamine-depleted striatum. The use of intracerebral microdialysis combined with a pharmacological approach has led to the discovery that serotonergic neurons are responsible for dopamine release induced by L-DOPA. The subsequent use of multisite microdialysis has further revealed that L-DOPA-stimulated dopamine release is widespread and related to the serotonergic innervation. The present Review emphasizes the functional impact of extrastriatal release of dopamine induced by L-DOPA in both the therapeutic and side effects of L-DOPA.

    Copyright © 2013 American Chemical Society

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    ACS Chemical Neuroscience

    Cite this: ACS Chem. Neurosci. 2013, 4, 5, 680–692
    Click to copy citationCitation copied!
    https://doi.org/10.1021/cn400046e
    Published March 31, 2013
    Copyright © 2013 American Chemical Society

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